_EC 5.1.3.2 UDP-glucose 4-epimerase. 29 PDB entries  
EC 5.-.-.- Isomerases. [2,272 PDB entries]
EC 5.1.-.- Racemases and epimerases. [296 PDB entries]
EC 5.1.3.- Acting on carbohydrates and derivatives. [128 PDB entries]
EC 5.1.3.2 UDP-glucose 4-epimerase. [29 PDB entries]    
1a9y

Pathway: UDP-glucose, UDP-galactose and UDP-glucuronate Biosynthesis
Reaction: UDP-alpha-D-glucose = UDP-alpha-D-galactose.
 


UDP-alpha-D-glucose
= UDP-alpha-D-galactose
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Galactowaldenase. UDP-galactose 4-epimerase. Uridine diphosphate galactose 4-epimerase. Uridine diphospho-galactose-4-epimerase.
Cofactor(s): NAD(+).
 

NAD(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also acts on UDP-2-deoxyglucose.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 29 PDB entries in enzyme class E.C.5.1.3.2

  PDB code Protein
1a9y
Udp-galactose 4-epimerase mutant s124a/y149f complexed with glucose
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1a9z
Udp-galactose 4-epimerase mutant s124a/y149f complexed with galactose
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1ek5
Structure of human udp-galactose 4-epimerase in complex with NAD+
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: foreskin. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chain: A (346 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme cofactor NAD(+)
1ek6
Structure of human udp-galactose 4-epimerase complexed with nadh and udp-glucose
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: foreskin. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (346 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAI corresponds to enzyme cofactor NAD(+)
1gy8
Trypanosoma brucei udp-galactose 4' epimerase
Source: Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (367 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme cofactor NAD(+)
1hzj
Human udp-galactose 4-epimerase: accommodation of udp-n- acetylglucosamine within the active site
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (345 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UD1 is 87.00% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1i3k
Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m- substituted udp-galactose 4-epimerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgale. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (347 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1i3l
Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m- substituted udp-galactose 4-epimerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgale. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (347 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group GDU corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1i3m
Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m- substituted udp-galactose 4-epimerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgale. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (347 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UD1 is 87.00% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1i3n
Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m- substituted udp-galactose 4-epimerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgale. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (347 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UD1 is 87.00% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1kvq
Udp-galactose 4-epimerase complexed with udp-phenol
Source: Escherichia coli. Organism_taxid: 562. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1kvr
Udp-galactose 4-epimerase complexed with udp-phenol
Source: Escherichia coli. Organism_taxid: 562. Cell_line: 293. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme cofactor NAD(+)
1kvs
Udp-galactose 4-epimerase complexed with udp-phenol
Source: Escherichia coli. Organism_taxid: 562. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1kvt
Udp-galactose 4-epimerase complexed with udp-phenol
Source: Escherichia coli. Organism_taxid: 562. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1kvu
Udp-galactose 4-epimerase complexed with udp-phenol
Source: Escherichia coli. Organism_taxid: 562. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1lrj
Crystal structure of e. Coli udp-galactose 4-epimerase compl udp-n-acetylglucosamine
Source: Escherichia coli. Organism_taxid: 562. Gene: gale. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: bl21(de3)plyss.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UD1 is 87.50% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1lrk
Crystal structure of escherichia coli udp-galactose 4-epimer y299c complexed with udp-n-acetylglucosamine
Source: Escherichia coli. Organism_taxid: 562. Gene: gale. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: bl21(de3)plyss.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UD1 is 87.50% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1lrl
Crystal structure of udp-galactose 4-epimerase mutant y299c with udp-glucose
Source: Escherichia coli. Organism_taxid: 562. Gene: gale. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: bl21(de3)plyss.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1nah
Udp-galactose 4-epimerase from escherichia coli, reduced
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme cofactor NAD(+)
1nai
Udp-galactose 4-epimerase from escherichia coli, oxidized
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme cofactor NAD(+)
1uda
Structure of udp-galactose-4-epimerase complexed with udp-4- fluoro-alpha-d-galactose
Source: Escherichia coli. Organism_taxid: 562
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UFG is 94.59% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1udb
Structure of udp-galactose-4-epimerase complexed with udp-4- fluoro-alpha-d-glucose
Source: Escherichia coli. Organism_taxid: 562
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UFG is 94.59% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1udc
Structure of udp-galactose-4-epimerase complexed with udp-ma
Source: Escherichia coli. Organism_taxid: 562
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UFM corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1xel
Udp-galactose 4-epimerase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
1z45
Crystal structure of the gal10 fusion protein galactose mutarotase/udp-galactose 4-epimerase from saccharomyces cer complexed with NAD, udp-glucose, and galactose
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gal10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (674 residues) CATH domains: 3.40.50.720 3.90.25.10 2.70.98.10
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
2c20
Crystal structure of udp-glucose 4-epimerase
Source: Bacillus anthracis. Organism_taxid: 198094. Strain: ames. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (329 residues) CATH domains: 3.40.50.720 3.90.25.10
Bound ligand:   Het Group NAD corresponds to enzyme cofactor NAD(+)
2cnb
Trypanosoma brucei udp-galactose-4-epimerase in ternary complex with NAD and the substrate analogue udp-4-deoxy-4- fluoro-alpha-d-galactose
Source: Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (366 residues) CATH domains: 3.40.50.720 3.90.25.10
Bound ligands:   Het Group UFG is 94.00% similar to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)
2udp
Udp-galactose 4-epimerase complexed with udp-phenol
Source: Escherichia coli. Organism_taxid: 562. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (338 residues) CATH domains: 3.90.25.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme cofactor NAD(+)
3enk
1.9a crystal structure of udp-glucose 4-epimerase from burkh pseudomallei
Source: Burkholderia pseudomallei 1710b. Organism_taxid: 320372. Strain: 1710b. Gene: burps1710b_2458, burps1710b_3147, gale, msrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (340 residues) CATH domains: 3.40.50.720 3.90.25.10
Bound ligands:   Het Group UPG corresponds to enzyme reactant UDP-glucose
  Het Group NAD corresponds to enzyme cofactor NAD(+)