_EC 5.1.1.1 Alanine racemase. 49 PDB entries  
EC 5.-.-.- Isomerases. [2,272 PDB entries]
EC 5.1.-.- Racemases and epimerases. [296 PDB entries]
EC 5.1.1.- Acting on amino acids and derivatives. [116 PDB entries]
EC 5.1.1.1 Alanine racemase. [49 PDB entries]    
1bd0

Reaction: L-alanine = D-alanine.
 


L-alanine
=
D-alanine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 49 PDB entries in enzyme class E.C.5.1.1.1

  PDB code Protein
1bd0
Alanine racemase complexed with alanine phosphonate
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Strain: xl-1 blue. Plasmid: pmdalr3
Chains: A, B (381 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligand:   Het Group IN5 is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1epv
Alanine racemase with bound inhibitor derived from d- cycloserine
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligand:   Het Group DCS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1ftx
Crystal stucture of alanine racemase in complex with d- alanine phosphonate
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (380 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligand:   Het Group EPC is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1l6f
Alanine racemase bound with n-(5'-phosphopyridoxyl)-l- alanine
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligand:   Het Group PP3 is 68.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1l6g
Alanine racemase bound with n-(5'-phosphopyridoxyl)-d- alanine
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligand:   Het Group PDD is 68.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1niu
Alanine racemase with bound inhibitor derived from l- cycloserine
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: alr or dal. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (382 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligand:   Het Group DCS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1rcq
The 1.45 a crystal structure of alanine racemase from a path bacterium, pseudomonas aeruginosa, contains both internal a external aldimine forms
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: dadx. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (357 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligands:   Het Group DLY is 60.00% similar to enzyme reactant L-alanine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1sft
Alanine racemase
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Strain: ifo 12550. Gene: alr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligands:   Het Group ACT is 66.67% similar to enzyme reactant L-alanine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1vfh
Crystal structure of alanine racemase from d-cycloserine pro streptomyces lavendulae
Source: Streptomyces lavendulae. Organism_taxid: 1914. Gene: alr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (382 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1vfs
Crystal structure of d-cycloserine-bound form of alanine racemase from d-cycloserine-producing streptomyces lavendulae
Source: Streptomyces lavendulae. Organism_taxid: 1914. Gene: alr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (383 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group DCS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1vft
Crystal structure of l-cycloserine-bound form of alanine racemase from d-cycloserine-producing streptomyces lavendulae
Source: Streptomyces lavendulae. Organism_taxid: 1914. Gene: alr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group DCS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1xfc
The 1.9 a crystal structure of alanine racemase from mycobac tuberculosis contains a conserved entryway into the active
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: alr. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (366 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1xqk
Effect of a y265f mutant on the transamination based cycloserine inactivation of alanine racemase
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: alr, dal. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PMH is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1xql
Effect of a y265f mutant on the transamination based cyclose inactivation of alanine racemase
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: alr, dal. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligands:   Het Group 4AX is 62.50% similar to enzyme reactant L-alanine
  Het Group PMP is 88.24% similar to enzyme cofactor pyridoxal
2dy3
Crystal structure of alanine racemase from corynebacterium g
Source: Corynebacterium glutamicum. Organism_taxid: 1718. Gene: alr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (338 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2odo
Crystal structure of pseudomonas fluorescens alanine racemas
Source: Pseudomonas fluorescens. Organism_taxid: 294. Strain: tm5-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (356 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group ACT is 66.67% similar to enzyme reactant L-alanine
2rgy
Crystal structure of transcriptional regulator of laci famil burkhoderia phymatum
Source: Burkholderia phymatum. Organism_taxid: 391038. Strain: stm815. Gene: bphydraft_4885. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (275 residues) CATH domains: 3.40.50.2300 3.40.50.2300
2rjg
Crystal structure of biosynthetic alaine racemase from esche coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: jm109. Gene: alr. Expressed in: escherichia coli.
Chains: A, B, C, D (359 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2rjh
Crystal structure of biosynthetic alaine racemase in d- cycloserine-bound form from escherichia coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: jm109. Gene: alr. Expressed in: escherichia coli.
Chains: A, B, C, D (359 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group DCS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2sfp
Alanine racemase with bound propionate inhibitor
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Strain: ifo 12550. Expressed in: escherichia coli str. K12 substr. W3110. Expression_system_taxid: 316407.
Chains: A, B (379 residues) CATH domains: 3.20.20.10 2.40.37.10
Bound ligands:   Het Group PPI is 83.33% similar to enzyme reactant L-alanine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2vd8
The crystal structure of alanine racemase from bacillus anthracis (ba0252)
Source: Bacillus anthracis. Organism_taxid: 198094. Strain: ames. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.37.10 3.20.20.10
2vd9
The crystal structure of alanine racemase from bacillus anthracis (ba0252) with bound l-ala-p
Source: Bacillus anthracis. Organism_taxid: 198094. Strain: ames. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (386 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group IN5 is 65.22% similar to enzyme cofactor pyridoxal
3b8t
Crystal structure of escherichia coli alaine racemase mutant
Source: Escherichia coli. Organism_taxid: 83333. Strain: jm109. Gene: alr. Expressed in: escherichia coli.
Chains: A, B, C, D (359 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3b8u
Crystal structure of escherichia coli alaine racemase mutant
Source: Escherichia coli. Organism_taxid: 83333. Strain: jm109. Gene: alr. Expressed in: escherichia coli.
Chains: A, B, C, D (359 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3b8v
Crystal structure of escherichia coli alaine racemase mutant
Source: Escherichia coli. Organism_taxid: 83333. Strain: jm109. Gene: alr. Expressed in: escherichia coli.
Chains: A, B, C, D (359 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3b8w
Crystal structure of escherichia coli alaine racemase mutant
Source: Escherichia coli. Organism_taxid: 83333. Strain: jm109. Gene: alr. Expressed in: escherichia coli.
Chains: A, B, C, D (359 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3bbl
Crystal structure of a regulatory protein of laci family fro chloroflexus aggregans
Source: Chloroflexus aggregans. Organism_taxid: 326427. Strain: dsm 9485. Gene: caggdraft_0381. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (281 residues) CATH domains: 3.40.50.2300 3.40.50.2300
Bound ligand:   Het Group EDO is 42.86% similar to enzyme reactant L-alanine
3c3k
Crystal structure of an uncharacterized protein from actinob succinogenes
Source: Actinobacillus succinogenes. Organism_taxid: 339671. Strain: 130z. Gene: asuc_0357. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domains: 3.40.50.2300 3.40.50.2300
Bound ligand:   Het Group GOL is 50.00% similar to enzyme reactant L-alanine
3e5p
Crystal structure of alanine racemase from e.Faecalis
Source: Enterococcus faecalis. Streptococcus faecalis. Organism_taxid: 1351. Strain: v583. Gene: alr, ef_0849. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (370 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligands:   Het Group PPI is 83.33% similar to enzyme reactant L-alanine
  Het Group PLP corresponds to enzyme cofactor pyridoxal
3e6e
Crystal structure of alanine racemase from e.Faecalis complex with cycloserine
Source: Enterococcus faecalis. Streptococcus faecalis. Organism_taxid: 1351. Strain: v583. Gene: alr, ef_0849. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (370 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group DCS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
3ha1
Alanine racemase from bacillus anthracis (ames)
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Strain: ames. Gene: dal-1, dal1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (386 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group ACT is 66.00% similar to enzyme reactant L-alanine
3hur
Crystal structure of alanine racemase from oenococcus oeni
Source: Oenococcus oeni psu-1. Organism_taxid: 203123. Strain: baa-331. Gene: oeoe_1641. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (384 residues) CATH domains: 2.40.37.10 3.20.20.10
3kw3
Crystal structure of alanine racemase from bartonella hensel covalently bound pyridoxal phosphate
Source: Bartonella henselae. Rochalimaea henselae. Organism_taxid: 38323. Gene: alr, bh12810. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (344 residues) CATH domains: 2.40.37.10 3.20.20.10
3mub
The crystal structure of alanine racemase from streptococcus pneumoniae
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Strain: r800. Gene: alar, alr, sp_1698. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (367 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group BEZ is 50.00% similar to enzyme reactant L-alanine
3oo2
2.37 angstrom resolution crystal structure of an alanine rac (alr) from staphylococcus aureus subsp. Aureus col
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 93062. Strain: col. Gene: alr, alr1, sacol2060. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (379 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group BME is 42.00% similar to enzyme reactant L-alanine
3s46
The crystal structure of alanine racemase from streptococcus pneumoniae
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Strain: r800. Gene: alar, alr, sp_1698. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (367 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group BEZ is 50.00% similar to enzyme reactant L-alanine
3uw6
Crystal structure of engineered protein, northeast structura consortium target or120
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: alr, dal. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (372 residues) CATH domains: 2.40.37.10 3.20.20.10
4a3q
The 2.15 angstrom resolution crystal structure of staphyloco aureus alanine racemase
Source: Staphylococcus aureus. Organism_taxid: 1280. Strain: mu50. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B (356 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligands:   Het Group ACT is 66.67% similar to enzyme reactant L-alanine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4beq
Structure of vibrio cholerae broad spectrum racemase double mutant r173a, n174a
Source: Vibrio cholerae. Organism_taxid: 666. Atcc: 39315. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (386 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4beu
Structure of vibrio cholerae broad spectrum racemase
Source: Vibrio cholerae. Organism_taxid: 666. Atcc: 39315. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (392 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4bf5
Structure of broad spectrum racemase from aeromonas hydrophi
Source: Aeromonas hydrophila subsp. Hydrophila organism_taxid: 196023. Atcc: 7966. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (396 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant L-alanine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4bhy
Structure of alanine racemase from aeromonas hydrophila
Source: Aeromonas hydrophila subsp. Hydrophila organism_taxid: 196023. Atcc: 7966. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (325 residues) CATH domains: 2.40.37.10 3.20.20.10
4dyj
Crystal structure of a broad specificity amino acid racemase within internal aldimine linkage
Source: Pseudomonas putida. Organism_taxid: 303. Strain: dsm84. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (384 residues) CATH domains: 2.40.37.10 3.20.20.10
4dza
Crystal structure of a lysine racemase within internal aldim linkage
Source: Proteus mirabilis. Organism_taxid: 584. Strain: bcrc10725. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (371 residues) CATH domains: 2.40.37.10 3.20.20.10
4fs9
Complex structure of a broad specificity amino acid racemase within the reactive intermediate
Source: Pseudomonas putida. Organism_taxid: 303. Strain: dsm84. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (384 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group PE1 is 57.69% similar to enzyme cofactor pyridoxal
4ils
Crystal structure of engineered protein. Northeast structura consortium target or117
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3)gold.
Chains: A, B, C (350 residues) CATH domains: 2.40.37.10 3.20.20.10
4lus
Alanine racemase [clostridium difficile 630]
Source: Clostridium difficile. Organism_taxid: 272563. Strain: 630. Gene: alr2, cd630_34630. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_taxid: 4922
Chains: A, B, C, D (362 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group GOL is 50.00% similar to enzyme reactant L-alanine
4lut
Alanine racemase [clostridium difficile 630] complex with cy
Source: Clostridium difficile. Organism_taxid: 272563. Strain: 630. Gene: alr2, cd630_34630. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_taxid: 4922
Chains: A, B (375 residues) CATH domains: 2.40.37.10 3.20.20.10
Bound ligand:   Het Group DCS is 65.22% similar to enzyme cofactor pyridoxal
4luy
Crystal structure of cdalr mutant k 271 t
Source: Clostridium difficile. Organism_taxid: 272563. Strain: 630. Gene: alr2, cd630_34630. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (383 residues) CATH domains: 2.40.37.10 3.20.20.10