_EC 4.4.1.5 Lactoylglutathione lyase. 18 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.4.-.- Carbon-sulfur lyases. [122 PDB entries]
EC 4.4.1.- Carbon-sulfur lyases. [122 PDB entries]
EC 4.4.1.5 Lactoylglutathione lyase. [18 PDB entries]    
1bh5

Reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
 


(R)-S-lactoylglutathione
=
glutathione
+
methylglyoxal
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing). Aldoketomutase. Glyoxalase I. Ketone-aldehyde mutase. Methylglyoxalase.
Comments: Also acts on 3-phosphoglycerol-glutathione.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 18 PDB entries in enzyme class E.C.4.4.1.5

  PDB code Protein
1bh5
Human glyoxalase i q33e, e172q double mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (177 residues) CATH domain: 3.10.180.10
Bound ligand:   Het Group GTX is 82.00% similar to enzyme reactant (R)-S-lactoylglutathione
1f9z
Crystal structure of the ni(ii)-bound glyoxalase i from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (128 residues) CATH domain: 3.10.180.10
1fa5
Crystal structure of the zn(ii)-bound glyoxalase i of escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (128 residues) CATH domain: 3.10.180.10
1fa6
Crystal structure of the co(ii)-bound glyoxalase i of escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (128 residues) CATH domain: 3.10.180.10
1fa7
Crystal structure of cd(ii)-bound glyoxalase i of escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (128 residues) CATH domain: 3.10.180.10
1fa8
Crystal structure of the apo form glyoxalase i of escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (128 residues) CATH domain: 3.10.180.10
1fro
Human glyoxalase i with benzyl-glutathione inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (176 residues) CATH domain: 3.10.180.10
Bound ligand:   Het Group GSB is 79.00% similar to enzyme reactant (R)-S-lactoylglutathione
1qin
Human glyoxalase i complexed with s-(n-hydroxy-n-p- iodophenylcarbamoyl) glutathione
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: heterologously expressed
Chains: A, B (176 residues) CATH domain: 3.10.180.10
Bound ligand:   Het Group GIP is 64.71% similar to enzyme reactant (R)-S-lactoylglutathione
1qip
Human glyoxalase i complexed with s-p- nitrobenzyloxycarbonylglutathione
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: heterologously expressed
Chains: A, B, C, D (176 residues) CATH domain: 3.10.180.10
Bound ligands:   Het Group GNB is 61.11% similar to enzyme reactant (R)-S-lactoylglutathione
  Het Group BME is 50.00% similar to enzyme product methylglyoxal
2za0
Crystal structure of mouse glyoxalase i complexed with methyl-gerfelin
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: glo1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (180 residues) CATH domain: 3.10.180.10
3r6a
Crystal structure of an uncharacterized protein (hypothetica mm_3218) from methanosarcina mazei.
Source: Methanosarcina mazei. Organism_taxid: 192952. Strain: go1. Gene: glo_edi_brp_like, mm_3218. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (118 residues) CATH domain: Unassigned
Bound ligand:   Het Group ACT is 50.00% similar to enzyme product methylglyoxal
3uk7
Crystal structure of arabidopsis thaliana dj-1d
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: dj-1d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (386 residues) CATH domains: 3.40.50.880 3.40.50.880
3vw9
Human glyoxalase i with an n-hydroxypyridone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glo1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (176 residues) CATH domain: 3.10.180.10
3w0t
Human glyoxalase i with an n-hydroxypyridone derivative inhi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glo1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (176 residues) CATH domain: 3.10.180.10
3w0u
Human glyoxalase i with an n-hydroxypyridone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glo1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (175 residues) CATH domain: 3.10.180.10
4j2f
Crystal structure of a glutathione transferase family member ricinus communis, target efi-501866
Source: Ricinus communis. Castor bean. Organism_taxid: 3988. Gene: rcom_1023660. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (218 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GOL is 83.33% similar to enzyme product methylglyoxal
4kyh
Crystal structure of mouse glyoxalase i complexed with zopol
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: glo1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (177 residues) CATH domain: 3.10.180.10
4kyk
Crystal structure of mouse glyoxalase i complexed with indom
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: glo1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (179 residues) CATH domain: 3.10.180.10