_EC 4.4.1.22 S-(hydroxymethyl)glutathione synthase. 2 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.4.-.- Carbon-sulfur lyases. [122 PDB entries]
EC 4.4.1.- Carbon-sulfur lyases. [122 PDB entries]
EC 4.4.1.22 S-(hydroxymethyl)glutathione synthase. [2 PDB entries]    
1x6m

Reaction: S-(hydroxymethyl)glutathione = glutathione + formaldehyde.
 


S-(hydroxymethyl)glutathione
=
glutathione
+
formaldehyde
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glutathione-dependent formaldehyde-activating enzyme.
Comments: The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for Ec 1.1.1.284, in the formaldehyde- detoxification pathway. Formerly Ec 1.2.1.1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.4.4.1.22

  PDB code Protein
1x6m
Crystal structure of the glutathione-dependent formaldehyde- enzyme (gfa)
Source: Paracoccus denitrificans. Organism_taxid: 266. Gene: gfa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (196 residues) CATH domain: 3.90.1590.10
1xa8
Crystal structure analysis of glutathione-dependent formalde activating enzyme (gfa)
Source: Paracoccus denitrificans. Organism_taxid: 266. Gene: gfa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (196 residues) CATH domain: 3.90.1590.10
Bound ligand:   Het Group GSH corresponds to enzyme product glutathione