_EC 4.4.1.20 Leukotriene-C(4) synthase. 12 PDB entries  
EC 4.-.-.- Lyases. [3,676 PDB entries]
EC 4.4.-.- Carbon-sulfur lyases. [125 PDB entries]
EC 4.4.1.- Carbon-sulfur lyases. [125 PDB entries]
EC 4.4.1.20 Leukotriene-C(4) synthase. [12 PDB entries]    
2pno

Pathway: Leukotriene Biosynthesis
Reaction: Leukotriene C(4) = leukotriene A(4) + glutathione.
 


Leukotriene C(4)
=
leukotriene A(4)
+
glutathione
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Leukotriene A(4):glutathione S-leukotrienyltransferase. Leukotriene C(4) synthetase. LTC(4) synthase. LTC(4) synthetase.
Comments: The reaction proceeds in the direction of addition. Not identical with Ec 2.5.1.18. Formerly Ec 2.5.1.37.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.4.4.1.20

  PDB code Protein
2pno
Crystal structure of human leukotriene c4 synthase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: schizosaccharomyces pombe. Expression_system_taxid: 4896.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (146 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group LMT is 70.37% similar to enzyme product leukotriene
  Het Group GSH corresponds to enzyme product glutathione
2uuh
Crystal structure of human leukotriene c4 synthase in complex with substrate glutathione
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (151 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group LMU is 48.72% similar to enzyme product leukotriene
  Het Group GSH corresponds to enzyme product glutathione
2uui
Crystal structure of human leukotriene c4 synthase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (156 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group PLM is 41.00% similar to enzyme reactant Leukotriene C(4)
  Het Group LMT is 48.00% similar to enzyme product leukotriene A(4)
3b29
Human leukotriene c4 synthase in complex with dodecyl-beta-d selenomaltoside
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltc4s. Expressed in: schizosaccharomyces pombe. Expression_system_taxid: 4896
Chain: A (142 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group LSM is 52.17% similar to enzyme product leukotriene
  Het Group GSH corresponds to enzyme product glutathione
3hkk
Structure of human leukotriene c4 synthase in complex with g sulfonate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (145 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group PAM is 52.00% similar to enzyme product leukotriene A(4)
  Het Group GTS is 86.00% similar to enzyme product glutathione
3leo
Structure of human leukotriene c4 synthase mutant r31q in co glutathione
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (150 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group LMT is 48.72% similar to enzyme product leukotriene
  Het Group GSH corresponds to enzyme product glutathione
3pcv
Crystal structure analysis of human leukotriene c4 synthase angstrom resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltc4s. Expressed in: schizosaccharomyces pombe. Expression_system_taxid: 4896.
Chain: A (146 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group LMT is 60.87% similar to enzyme product leukotriene
  Het Group GSH corresponds to enzyme product glutathione
4j7t
Human ltc4 synthase in complex with product analogs - implic enzyme catalysis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltc4s. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (148 residues) CATH domain: 1.20.120.550
Bound ligand:   Het Group 1JO is 69.77% similar to enzyme reactant Leukotriene
4j7y
Human ltc4 synthase in complex with product analogs - implic enzyme catalysis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltc4s. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (148 residues) CATH domain: 1.20.120.550
Bound ligand:   Het Group 1JP is 68.18% similar to enzyme reactant Leukotriene
4jc7
Human ltc4 synthase in complex with product analogs - implic enzyme catalysis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltc4s. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (155 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group PAM is 78.26% similar to enzyme product leukotriene
  Het Group GTX is 76.92% similar to enzyme product glutathione
4jcz
Human ltc4 synthase in complex with product analogs - implic enzyme catalysis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltc4s. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (147 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group PAM is 78.26% similar to enzyme product leukotriene
  Het Group GTX is 76.92% similar to enzyme product glutathione
4jrz
Human ltc4 synthase in complex with product analogs - implic enzyme catalysis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltc4s. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (156 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group PAM is 78.26% similar to enzyme product leukotriene
  Het Group GTX is 76.92% similar to enzyme product glutathione