_EC 4.4.1.14 1-aminocyclopropane-1-carboxylate synthase. 7 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.4.-.- Carbon-sulfur lyases. [122 PDB entries]
EC 4.4.1.- Carbon-sulfur lyases. [122 PDB entries]
EC 4.4.1.14 1-aminocyclopropane-1-carboxylate synthase. [7 PDB entries]    
1b8g

Pathway: Ethylene Biosynthesis
Reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.
 


S-adenosyl-L-methionine
=
1-aminocyclopropane-1-carboxylate
+
methylthioadenosine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 1-aminocyclopropane-1-carboxylic acid synthase. Acc synthase. Aminocyclopropanecarboxylate synthase. S-adenosyl-L-methionine methylthioadenosine-lyase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Catalyzes an alpha,gamma-elimination.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.4.4.1.14

  PDB code Protein
1b8g
1-aminocyclopropane-1-carboxylate synthase
Source: Malus x domestica. Organism_taxid: 3750. Tissue: fruit cortical tissue. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (421 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1iax
Crystal structure of acc synthase complexed with plp
Source: Solanum lycopersicum. Organism_taxid: 4081. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (417 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1iay
Crystal structure of acc synthase complexed with cofactor pl inhibitor avg
Source: Solanum lycopersicum. Organism_taxid: 4081. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (419 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group AVG is 63.64% similar to enzyme product 1-aminocyclopropane-1-carboxylate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1m4n
Crystal structure of apple acc synthase in complex with [2-( oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium
Source: Malus x domestica. Organism_taxid: 3750. Tissue: fruit cortical. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (421 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group AAD is 83.33% similar to enzyme product S-methyl-5'-thioadenosine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1m7y
Crystal structure of apple acc synthase in complex with l- aminoethoxyvinylglycine
Source: Malus x domestica. Organism_taxid: 3750. Tissue: fruit cortical. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (424 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group MRD is 50.00% similar to enzyme product 1-aminocyclopropane-1-carboxylate
  Het Group PPG is 55.56% similar to enzyme cofactor pyridoxal
1ynu
Crystal structure of apple acc synthase in complex with l-vi
Source: Malus x domestica. Organism_taxid: 3750. Strain: golden delicious. Tissue: fruit cortical tissue. Gene: acs-1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (417 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group TRS is 66.67% similar to enzyme product 1-aminocyclopropane-1-carboxylate
  Het Group PY4 is 65.22% similar to enzyme cofactor pyridoxal
3piu
High-resolution structure of native malus domestica acc synt
Source: Malus domestica. Apple. Organism_taxid: 3750. Gene: acs-1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLR is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate