_EC 4.4.1.13 Cysteine-S-conjugate beta-lyase. 10 PDB entries  
EC 4.-.-.- Lyases. [3,615 PDB entries]
EC 4.4.-.- Carbon-sulfur lyases. [120 PDB entries]
EC 4.4.1.- Carbon-sulfur lyases. [120 PDB entries]
EC 4.4.1.13 Cysteine-S-conjugate beta-lyase. [10 PDB entries]    
1w7l

Reaction: RS-CH(2)-CH(NH(3)(+))COO(-) + H(2)O = Rsh + NH(3) + pyruvate.
 


RS-CH(2)-CH(NH(3)(+))COO(-)
+ H(2)O
=
RSH
+ NH(3)
+
pyruvate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-cysteine-S-conjugate thiol-lyase (deaminating).
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: R may represent aromatic compounds such as 4-bromobenzene and 2,4- dinitrobenzene.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 10 PDB entries in enzyme class E.C.4.4.1.13

  PDB code Protein
1w7l
Crystal structure of human kynurenine aminotransferase i
Source: Homo sapiens. Human. Organ: liver. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (415 residues) CATH domains: 3.90.1150.10 3.40.640.10
1w7m
Crystal structure of human kynurenine aminotransferase i in complex with l-phe
Source: Homo sapiens. Human. Organ: liver. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (415 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group DPN is 42.00% similar to enzyme reactant RS-CH(2)-CH(NH(3)(+))COO(-)
1w7n
Crystal structure of human kynurenine aminotransferase i in pmp form
Source: Homo sapiens. Human. Organ: liver. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (415 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 88.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2zjg
Crystal structural of mouse kynurenine aminotransferase iii
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme product pyruvate
3e2f
Crystal structure of mouse kynurenine aminotransferase iii, form
Source: Mus musculus. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme product pyruvate
3e2y
Crystal structure of mouse kynurenine aminotransferase iii i with glutamine
Source: Mus musculus. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GLN is 50.00% similar to enzyme reactant RS-CH(2)-CH(NH(3)(+))COO(-)
  Het Group PMP is 88.24% similar to enzyme cofactor pyridoxal
3e2z
Crystal structure of mouse kynurenine aminotransferase iii i with kynurenine
Source: Mus musculus. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GOL is 71.43% similar to enzyme product pyruvate
  Het Group PMP is 88.24% similar to enzyme cofactor pyridoxal
3fvs
Human kynurenine aminotransferase i in complex with glycerol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccbl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (419 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme product pyruvate
3fvu
Crystal structure of human kynurenine aminotransferase i in with indole-3-acetic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccbl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (419 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GOL is 71.43% similar to enzyme product pyruvate
  Het Group IAC is 45.00% similar to enzyme cofactor pyridoxal
3fvx
Human kynurenine aminotransferase i in complex with tris
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccbl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (419 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group TRS is 45.00% similar to enzyme reactant RS-CH(2)-CH(NH(3)(+))COO(-)