_EC 4.4.1.11 Methionine gamma-lyase. 17 PDB entries  
EC 4.-.-.- Lyases. [3,676 PDB entries]
EC 4.4.-.- Carbon-sulfur lyases. [125 PDB entries]
EC 4.4.1.- Carbon-sulfur lyases. [125 PDB entries]
EC 4.4.1.11 Methionine gamma-lyase. [17 PDB entries]    
1e5f

Reaction: L-methionine + H(2)O = methanethiol + NH(3) + 2-oxobutanoate.
 


L-methionine
+ H(2)O
=
methanethiol
+ NH(3)
+
2-oxobutanoate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-methioninase. Methionine lyase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 17 PDB entries in enzyme class E.C.4.4.1.11

  PDB code Protein
1e5f
Methionine gamma-lyase (mgl) from trichomonas vaginalis
Source: Trichomonas vaginalis. Organism_taxid: 412133. Strain: g3. Cellular_location: cytoplasm. Gene: mgl1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (393 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group GOL is 62.50% similar to enzyme product 2-oxobutanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1gc0
Crystal structure of the pyridoxal-5'-phosphate dependent l- methionine gamma-lyase from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303
Chains: A, B, C, D (355 residues) CATH domains: 3.40.640.10 3.90.1150.10
1gc2
Crystal structure of the pyridoxal-5'-phosphate dependent l- methionine gamma-lyase from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303
Chains: A, B, C, D (373 residues) CATH domains: 3.40.640.10 3.90.1150.10
1pff
Crystal structure of homocysteine alpha-, gamma-lyase at 1.8 angstroms
Source: Trichomonas vaginalis. Organism_taxid: 5722
Chains: A, B (331 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group EDO is 57.00% similar to enzyme product 2-oxobutanoate
1pg8
Crystal structure of l-methionine alpha-, gamma-lyase
Source: Pseudomonas putida. Organism_taxid: 303
Chains: A, B, C, D (398 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group PEG is 40.00% similar to enzyme product 2-oxobutanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1ukj
Detailed structure of l-methionine-lyase from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (398 residues) CATH domains: 3.40.640.10 3.90.1150.10
2o7c
Crystal structure of l-methionine-lyase from pseudomonas
Source: Pseudomonas putida. Organism_taxid: 303. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (398 residues) CATH domains: 3.40.640.10 3.90.1150.10
3acz
Crystal structure of entamoeba histolytica methionine gamma-
Source: Entamoeba histolytica. Organism_taxid: 5759. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (387 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group GOL is 62.50% similar to enzyme product 2-oxobutanoate
3aej
Reaction intermediate structure of entamoeba histolytica met gamma-lyase 1 tetramer containing michaelis complex and met pyridoxal-5'-phosphate
Source: Entamoeba histolytica. Organism_taxid: 5759. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (387 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group AA5 is 60.00% similar to enzyme cofactor pyridoxal
3ael
Reaction intermediate structure of entamoeba histolytica met gamma-lyase 1 containing methionine imine-pyridoxamine-5'-p and alpha-amino-alpha, beta-butenoic acid-pyridoxal-5'-phos
Source: Entamoeba histolytica. Organism_taxid: 5759. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (387 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group MEE corresponds to enzyme product Methanethiol
  Het Group GOL is 62.50% similar to enzyme product 2-oxobutanoate
  Het Group 4LM is 65.22% similar to enzyme cofactor pyridoxal
3aem
Reaction intermediate structure of entamoeba histolytica met gamma-lyase 1 containing michaelis complex and methionine i pyridoxamine-5'-phosphate
Source: Entamoeba histolytica. Organism_taxid: 5759. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (387 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group 2LM is 60.00% similar to enzyme cofactor pyridoxal
3aen
Reaction intermediate structure of entamoeba histolytica met gamma-lyase 1 containing michaelis complex and alpha-amino- beta-butenoic acid-pyridoxal-5'-phosphate
Source: Entamoeba histolytica. Organism_taxid: 5759. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (387 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group 4LM is 65.22% similar to enzyme cofactor pyridoxal
3aeo
Reaction intermediate structure of entamoeba histolytica met gamma-lyase 1 containing methionine alpha, beta-enamine-pyr 5'-phosphate
Source: Entamoeba histolytica. Organism_taxid: 5759. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (387 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group GOL is 62.50% similar to enzyme product 2-oxobutanoate
  Het Group 3LM is 60.00% similar to enzyme cofactor pyridoxal
3aep
Reaction intermediate structure of entamoeba histolytica met gamma-lyase 1 containing alpha-amino-alpha, beta-butenoic a pyridoxal-5'-phosphate
Source: Entamoeba histolytica. Organism_taxid: 5759. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (387 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group MEE corresponds to enzyme product Methanethiol
  Het Group GOL is 62.50% similar to enzyme product 2-oxobutanoate
  Het Group 4LM is 65.22% similar to enzyme cofactor pyridoxal
3vk2
Crystal structure of l-methionine gamma-lyase from pseudomon c116h mutant.
Source: Pseudomonas putida. Organism_taxid: 303. Gene: mdea. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (393 residues) CATH domains: 3.40.640.10 3.90.1150.10
3vk3
Crystal structure of l-methionine gamma-lyase from pseudomon c116h mutant complexed with l-methionine
Source: Pseudomonas putida. Organism_taxid: 303. Gene: mdea. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (397 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3vk4
Crystal structure of l-methionine gamma-lyase from pseudomon c116h mutant complexed with l-homocysteine
Source: Pseudomonas putida. Organism_taxid: 303. Gene: mdea. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (392 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group HCS is 88.89% similar to enzyme reactant L-methionine