_EC 4.3.1.3 Histidine ammonia-lyase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.3.-.- Carbon-nitrogen lyases. [242 PDB entries]
EC 4.3.1.- Ammonia-lyases. [104 PDB entries]
EC 4.3.1.3 Histidine ammonia-lyase. [6 PDB entries]    
1b8f

Pathway: Histidine Catabolism
Reaction: L-histidine = urocanate + NH(3).
 


L-histidine
=
urocanate
+ NH(3)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Histidase. Histidinase. Histidine alpha-deaminase.
Comments: Member of the aromatic amino acid lyase family, other members of which are Ec 4.3.1.23, Ec 4.3.1.24 and Ec 4.3.1.25. Catalyzes the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.3.1.3

  PDB code Protein
1b8f
Histidine ammonia-lyase (hal) from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303. Atcc: 12633. Cellular_location: cytoplasm. Gene: huth. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (507 residues) CATH domains: 1.10.275.10 1.20.200.10
1eb4
Histidine ammonia-lyase (hal) mutant f329a from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303. Atcc: 12633. Cellular_location: cytoplasm. Gene: huth. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (507 residues) CATH domains: 1.10.275.10 1.20.200.10
1gk2
Histidine ammonia-lyase (hal) mutant f329g from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (509 residues) CATH domains: 1.10.275.10 1.20.200.10
1gk3
Histidine ammonia-lyase (hal) mutant d145a from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (509 residues) CATH domains: 1.10.275.10 1.20.200.10
1gkj
Histidine ammonia-lyase (hal) mutant y280f from pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 303. Strain: bl21(de3). Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (507 residues) CATH domains: 1.10.275.10 1.20.200.10
1gkm
Histidine ammonia-lyase (hal) from pseudomonas putida inhibited with l-cysteine
Source: Pseudomonas putida. Organism_taxid: 303. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (507 residues) CATH domains: 1.10.275.10 1.20.200.10
Bound ligand:   Het Group CYS is 50.00% similar to enzyme reactant L-histidine