_EC 4.3.1.23 Tyrosine ammonia-lyase. 12 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.3.-.- Carbon-nitrogen lyases. [242 PDB entries]
EC 4.3.1.- Ammonia-lyases. [104 PDB entries]
EC 4.3.1.23 Tyrosine ammonia-lyase. [12 PDB entries]    
2o6y

Reaction: L-tyrosine = trans-p-hydroxycinnamate + ammonia.
 


L-tyrosine
=
trans-p-hydroxycinnamate
+ ammonia
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-tyrosine ammonia-lyase. Tal. Tyrase.
Cofactor(s): Mio.
Comments: Member of the aromatic amino acid lyase family, other members of which are Ec 4.3.1.3, Ec 4.3.1.24 and Ec 4.3.1.25. Far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides. Formerly Ec 4.3.1.5.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.4.3.1.23

  PDB code Protein
2o6y
Tyrosine ammonia-lyase from rhodobacter sphaeroides
Source: Rhodobacter sphaeroides. Organism_taxid: 1063. Gene: huth. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (515 residues) CATH domains: 1.10.275.10 1.20.200.10
2o78
Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant) complexed with cinnamic acid
Source: Rhodobacter sphaeroides. Organism_taxid: 1063. Gene: huth. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (515 residues) CATH domains: 1.10.275.10 1.20.200.10
Bound ligand:   Het Group TCA is 50.00% similar to enzyme product urocanate
2o7b
Tyrosine ammonia-lyase from rhodobacter sphaeroides, complexed with coumarate
Source: Rhodobacter sphaeroides. Organism_taxid: 1063. Gene: huth. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (515 residues) CATH domains: 1.10.275.10 1.20.200.10
Bound ligand:   Het Group HC4 is 46.00% similar to enzyme product urocanate
2o7d
Tyrosine ammonia-lyase from rhodobacter sphaeroides, complexed with caffeate
Source: Rhodobacter sphaeroides. Organism_taxid: 1063. Gene: huth. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (515 residues) CATH domains: 1.10.275.10 1.20.200.10
Bound ligand:   Het Group DHC is 43.00% similar to enzyme product urocanate
2o7e
Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid
Source: Rhodobacter sphaeroides. Organism_taxid: 1063. Gene: huth. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (515 residues) CATH domains: 1.10.275.10 1.20.200.10
2o7f
Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), complexed with coumaric acid
Source: Rhodobacter sphaeroides. Organism_taxid: 1063. Gene: huth. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (515 residues) CATH domains: 1.10.275.10 1.20.200.10
Bound ligand:   Het Group HC4 is 46.00% similar to enzyme product urocanate
2ohy
X-ray crystal structure of tyrosine aminomutase from strepto globisporus
Source: Streptomyces globisporus. Organism_taxid: 1908. Strain: sgcc4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (526 residues) CATH domains: 1.10.275.10 1.20.200.10
2qve
Crystal structure of sgtam bound to mechanism based inhibito
Source: Streptomyces globisporus. Organism_taxid: 1908. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (526 residues) CATH domains: 1.10.275.10 1.20.200.10
2rjr
Substrate mimic bound to sgtam
Source: Streptomyces globisporus. Organism_taxid: 1908. Gene: sgcc4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (526 residues) CATH domains: 1.10.275.10 1.20.200.10
Bound ligand:   Het Group 295 is 68.00% similar to enzyme reactant L-tyrosine
2rjs
Sgtam bound to substrate mimic
Source: Streptomyces globisporus. Organism_taxid: 1908. Gene: sgcc4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (526 residues) CATH domains: 1.10.275.10 1.20.200.10
Bound ligand:   Het Group 296 is 61.00% similar to enzyme reactant L-tyrosine
3kdy
X-ray crystal structure of tyrosine aminomutase mutant const
Source: Streptomyces globisporus. Organism_taxid: 1908. Gene: sgcc4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (527 residues) CATH domains: 1.10.275.10 1.20.200.10
3kdz
X-ray crystal structure of a tyrosine aminomutase mutant con with bound ligand
Source: Streptomyces globisporus. Organism_taxid: 1908. Gene: sgcc4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (527 residues) CATH domains: 1.10.275.10 1.20.200.10