_EC 4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase. 93 PDB entries  
EC 4.-.-.- Lyases. [3,385 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,616 PDB entries]
EC 4.2.99.- Other carbon-oxygen lyases. [103 PDB entries]
EC 4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase. [93 PDB entries]    
1bix

Reaction: The C-O-P bond 3' to the apurinic or apyrimidinic site in Dna is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Other name(s): Ap endonuclease class i. Ap lyase. Deoxyribonuclease (apurinic or apyrimidinic). E.coli endonuclease Iii. Endodeoxyribonuclease (apurinic or apyrimidinic). Micrococcus luteus Uv endonuclease. Phage-T(4) Uv endonuclease. Phage-T4 Uv endonuclease.
Comments: 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under the number Ec 3.1.25.2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 93 PDB entries in enzyme class E.C.4.2.99.18

  PDB code Protein
1bix
The crystal structure of the human DNA repair endonuclease hap1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (275 residues) CATH domain: 3.60.10.10
1cqg
High resolution solution nmr structure of mixed disulfide intermediate between human thioredoxin (c35a, c62a, c69a, c73a) mutant and a 13 residue peptide comprising its target site in human ref-1 (residues 59-71 of the p50 subunit of nfkb), nmr, 31 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential.
Chain: B (13 residues)
1cqh
High resolution solution nmr structure of mixed disulfide intermediate between human thioredoxin (c35a, c62a, c69a, c73a) mutant and a 13 residue peptide comprising its target site in human ref-1 (residues 59-71 of the p50 subunit of nfkb), nmr, minimized average structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential.
Chain: B (13 residues)
1de8
Human apurinic/apyrimidinic endonuclease-1 (ape1) bound to abasic DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: B, A (276 residues) CATH domain: 3.60.10.10
1de9
Human ape1 endonuclease with bound abasic DNA and mn2+ ion
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (276 residues) CATH domain: 3.60.10.10
1dew
Crystal structure of human ape1 bound to abasic DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (278 residues) CATH domain: 3.60.10.10
1e9n
A second divalent metal ion in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, ape1, and its implications for the catalytic mechanism
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ape1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (274 residues) CATH domain: 3.60.10.10
1ebm
Crystal structure of the human 8-oxoguanine glycosylase (hogg1) bound to a substrate oligonucleotide
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1ee8
Crystal structure of mutm (fpg) protein from thermus thermop
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (266 residues) CATH domains: 3.20.190.10 1.10.8.50
1fn7
Coupling of damage recognition and catalysis by a human base-excision DNA repair protein
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1hd7
A second divalent metal ion in the active site of a new crystal form of human apurinic/apyridinimic endonuclease, ape1, and its implications for the catalytic mechanism
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: all. Cell: all. Organelle: nucleus. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (259 residues) CATH domain: 3.60.10.10
1hu0
Crystal structure of an hogg1-DNA borohydride trapped intermediate complex
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1k3w
Crystal structure of a trapped reaction intermediate of the DNA repair enzyme endonuclease viii with DNA
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (254 residues) CATH domains: 3.20.190.10 1.10.8.50
1k3x
Crystal structure of a trapped reaction intermediate of the enzyme endonuclease viii with brominated-DNA
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (253 residues) CATH domains: 3.20.190.10 1.10.8.50
1k82
Crystal structure of e.Coli formamidopyrimidine-DNA glycosylase (fpg) covalently trapped with DNA
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562. Gene: fpg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (260 residues) CATH domains: 3.20.190.10 1.10.8.50
1kfv
Crystal structure of lactococcus lactis formamido-pyrimidine glycosylase (alias fpg or mutm) non covalently bound to an containing DNA.
Source: Synthetic: yes. Lactococcus lactis. Organism_taxid: 1358. Gene: mutm or fpg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domains: 3.20.190.10 1.10.8.50
1ko9
Native structure of the human 8-oxoguanine DNA glycosylase hogg1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (312 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1lwv
Borohydride-trapped hogg1 intermediate structure co- crystallized with 8-aminoguanine
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1lww
Borohydride-trapped hogg1 intermediate structure co- crystallized with 8-bromoguanine
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1lwy
Hogg1 borohydride-trapped intermediate without 8-oxoguanine
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1lyr
Theoretical model of bovine ap lyase, bap1
Source: Bos taurus. Bovine. Synthetic: yes. Synthetic: yes
Chain: A (279 residues)
1m3h
Crystal structure of hogg1 d268e mutant with product oligonucleotide
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1m3q
Crystal structure of hogg1 d268e mutant with base-excised DNA and 8-aminoguanine
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1n39
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: hogg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1n3a
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1n3c
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1nnj
Crystal structure complex between the lactococcus lactis fpg abasic site containing DNA
Source: Synthetic: yes. Lactococcus lactis. Organism_taxid: 1358. Gene: mutm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (267 residues) CATH domains: 3.20.190.10 1.10.8.50
1pji
Crystal structure of wild type lactococcus lactis fpg comple 1,3 propanediol containing DNA
Source: Synthetic: yes. Other_details: synthetic. Lactococcus lactis subsp. Cremoris. Organism_taxid: 1359. Strain: subsp. Cremoris. Gene: mutm or fpg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (267 residues) CATH domains: 3.20.190.10 1.10.8.50
1pjj
Complex between the lactococcus lactis fpg and an abasic sit containing DNA.
Source: Synthetic: yes. Lactococcus lactis. Organism_taxid: 1358. Gene: mutm or fpg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 3.20.190.10 1.10.8.50
1pm5
Crystal structure of wild type lactococcus lactis fpg comple tetrahydrofuran containing DNA
Source: Synthetic: yes. Other_details: synyhetic. Other_details: synthetic. Lactococcus lactis subsp. Cremoris. Organism_taxid: 1359. Strain: subsp. Cremoris. Gene: mutm or fpg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 3.20.190.10 1.10.8.50
1pu6
Crystal structure of h.Pylori 3-methyladenine DNA glycosylase (magiii)
Source: Helicobacter pylori. Organism_taxid: 210. Strain: 13-5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (217 residues) CATH domains: 1.10.1670.10 1.10.340.30
1pu7
Crystal structure of h.Pylori 3-methyladenine DNA glycosylas bound to 3,9-dimethyladenine
Source: Helicobacter pylori. Organism_taxid: 210. Strain: 13-5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (215 residues) CATH domains: 1.10.1670.10 1.10.340.30
1pu8
Crystal structure of h.Pylori 3-methyladenine DNA glycosylas bound to 1,n6-ethenoadenine
Source: Helicobacter pylori. Organism_taxid: 210. Strain: 13-5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (216 residues) CATH domains: 1.10.1670.10 1.10.340.30
1q39
Crystal structure of the DNA repair enzyme endonuclease-viii from e. Coli: the wt enzyme at 2.8 resolution.
Source: Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (257 residues) CATH domains: 3.20.190.10 1.10.8.50
1q3b
Crystal structure of the DNA repair enzyme endonuclease-viii from e. Coli: the r252a mutant at 2.05 resolution.
Source: Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (259 residues) CATH domains: 3.20.190.10 1.10.8.50
1q3c
Crystal structure of the DNA repair enzyme endonuclease-viii from e. Coli: the e2a mutant at 2.3 resolution.
Source: Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (250 residues) CATH domains: 3.20.190.10 1.10.8.50
1tdh
Crystal structure of human endonuclease viii-like 1 (neil1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (284 residues) CATH domains: 3.20.190.10 1.10.8.50
1tdz
Crystal structure complex between the lactococcus lactis fpg and a fapy-dg containing DNA
Source: Synthetic: yes. Lactococcus lactis. Organism_taxid: 1358. Gene: mutm, fpg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (265 residues) CATH domains: 3.20.190.10 1.10.8.50
1xc8
Crystal structure complex between the wild-type lactococcus (mutm) and a fapy-dg containing DNA
Source: Synthetic: yes. Lactococcus lactis subsp. Cremoris. Organism_taxid: 1359. Strain: subsp. Cremoris. Variant: subsp. Cremoris. Gene: mutm, fpg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 3.20.190.10 1.10.8.50
1xg7
Conserved hypothetical protein pfu-877259-001 from pyrococcu
Source: Pyrococcus furiosus. Organism_taxid: 186497. Strain: dsm 3638. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (245 residues) CATH domains: 1.10.1670.10 1.10.340.30
1xqo
Crystal structure of native pa-agog, 8-oxoguanine DNA glycos pyrobaculum aerophilum
Source: Pyrobaculum aerophilum. Organism_taxid: 13773. Gene: pa-agog. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (253 residues) CATH domains: 1.10.1670.10 1.10.340.30
1xqp
Crystal structure of 8-oxoguanosine complexed pa-agog, 8-oxo DNA glycosylase from pyrobaculum aerophilum
Source: Pyrobaculum aerophilum. Organism_taxid: 13773. Gene: pa-agog. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (252 residues) CATH domains: 1.10.1670.10 1.10.340.30
1xzr
Theoretical model of bovine ap lyase, bap1 mutant: 176 arg to ala
Source: Bos taurus. Bovine. Synthetic: yes. Synthetic: yes
Chain: A (279 residues)
1xzs
Theoretical model of bovine ap lyase, bap1 mutant: 282 asp to ala
Source: Bos taurus. Bovine. Synthetic: yes. Synthetic: yes
Chain: A (279 residues)
1xzt
Theoretical model of bovine ap lyase, bap1 mutant: 308 his to asn
Source: Bos taurus. Bovine. Synthetic: yes. Synthetic: yes
Chain: A (279 residues)
1yqk
Human 8-oxoguanine glycosylase crosslinked with guanine cont
Source: Synthetic: yes. Other_details: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (312 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1yql
Catalytically inactive hogg1 crosslinked with 7-deaza-8- azaguanine containing DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1yqm
Catalytically inactive human 8-oxoguanine glycosylase crosslinked to 7-deazaguanine containing DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
1yqr
Catalytically inactive human 8-oxoguanine glycosylase crosslinked to oxog containing DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2abk
Refinement of the native structure of endonuclease iii to a resolution of 1.85 angstrom
Source: Escherichia coli. Organism_taxid: 562. Strain: uc 6444 delta nth
Chain: A (211 residues) CATH domains: 1.10.340.30 1.10.1670.10
2ea0
Crystal structure of the DNA repair enzyme endonuclease-viii from e. Coli in complex with ap-site containing DNA substra
Source: Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chain: A (254 residues) CATH domains: 3.20.190.10 1.10.8.50
2i5w
Structure of hogg1 crosslinked to DNA sampling a normal g ad an oxog
Source: Synthetic: yes. Other_details: synthesized by solid phase DNA synthesis and subsequent manipulations.. Other_details: synthesized by solid phase DNA synthesis. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3).
Chain: A (311 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2isi
Crystal structure of ape1 from homo sapiens in a new crystal form complexed with a ligand
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (276 residues) CATH domain: 3.60.10.10
2j63
Crystal structure of ap endonuclease lmap from leishmania major
Source: Leishmania major. Organism_taxid: 5664. Strain: 252. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: isolated in iran and provided by s. Meshnik
Chains: A, B (333 residues) CATH domain: 0.0.0.0
2kqb
First pbz domain of human aplf protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aplf, c2orf13, palf, xip1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (55 residues)
2kqc
Second pbz domain of human aplf protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aplf, c2orf13, palf, xip1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (47 residues)
2kqd
First pbz domain of human aplf protein in complex with ribofuranosyladenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aplf, c2orf13, palf, xip1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (55 residues)
2kqe
Second pbz domain of human aplf protein in complex with ribofuranosyladenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aplf, c2orf13, palf, xip1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (47 residues)
2kuo
Structure and identification of adp-ribose recognition motif and role in the DNA damage response
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aplf, aplf(c2orf13), c2orf13, palf, xip1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (91 residues)
2nob
Structure of catalytically inactive h270a human 8- oxoguanine glycosylase crosslinked to 8-oxoguanine DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2noe
Structure of catalytically inactive g42a human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2nof
Structure of q315f human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (312 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2noh
Structure of catalytically inactive q315a human 8- oxoguanine glycosylase complexed to 8-oxoguanine DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (313 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2noi
Structure of g42a human 8-oxoguanine glycosylase crosslinked to undamaged g-containing DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (313 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2nol
Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxog DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2noz
Structure of q315f human 8-oxoguanine glycosylase distal crosslink to 8-oxoguanine DNA
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: ogg1, mmh, mutm, ogh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (310 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2o3c
Crystal structure of zebrafish ape
Source: Danio rerio. Zebrafish. Organism_taxid: 7955. Gene: apex1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (276 residues) CATH domain: 0.0.0.0
2o3h
Crystal structure of the human c65a ape
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: apex1, ape, apex, apx, hap1, ref1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (280 residues) CATH domain: 3.60.10.10
2opf
Crystal structure of the DNA repair enzyme endonuclease-viii from e. Coli (r252a) in complex with ap-site containing dna
Source: Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chain: A (256 residues) CATH domains: 3.20.190.10 1.10.8.50
2oq4
Crystal structure of the DNA repair enzyme endonuclease- viii (nei) from e. Coli (e2q) in complex with ap-site containing DNA substrate
Source: Escherichia coli. Organism_taxid: 562. Gene: nei. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chains: A, B (252 residues) CATH domains: 3.20.190.10 1.10.8.50
2xhi
Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
Chain: A (316 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
2xzf
Crystal structure of a complex between the wild-type lactococcus lactis fpg (mutm) and an oxidized pyrimidine containing DNA at 293k
Source: Lactococcus lactis subsp. Cremoris. Organism_taxid: 1359. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Organism_taxid: 32630
Chain: A (266 residues) CATH domains: 3.20.190.10 1.10.8.50
2xzu
Crystal structure of a complex between the wild-type lactococcus lactis fpg (mutm) and an oxidized pyrimidine containing DNA at 310k
Source: Lactococcus lactis. Organism_taxid: 1359. Strain: subsp cremoris. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Organism_taxid: 32630
Chain: A (266 residues) CATH domains: 3.20.190.10 1.10.8.50
3a42
Crystal structure of mvnei1
Source: Acanthamoeba polyphaga mimivirus. Apmv. Organism_taxid: 212035. Gene: l315, mimi_l315. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domain: 3.20.190.10
3a45
Crystal structure of mvnei1_2
Source: Acanthamoeba polyphaga mimivirus. Apmv. Organism_taxid: 212035. Gene: l315. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (288 residues) CATH domain: 3.20.190.10
3a46
Crystal structure of mvnei1/thf complex
Source: Acanthamoeba polyphaga mimivirus. Apmv. Organism_taxid: 212035. Gene: l315. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: nucleotide synthesis. Other_details: nucleotide synthesis
Chains: A, B (288 residues) CATH domain: 3.20.190.10
3c58
Crystal structure of a complex between the wild-type lactoco lactis fpg (mutm) and a n7-benzyl-fapy-dg containing DNA
Source: Lactococcus lactis. Organism_taxid: 416870. Variant: subsp. Cremoris. Gene: mutm, fpg. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic DNA. Other_details: synthetic DNA
Chain: A (269 residues) CATH domains: 3.20.190.10 1.10.8.50
3fhf
Crystal structure of methanocaldococcus jannaschii 8-oxoguan glycosylase (mjogg)
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Gene: 1451601, mj0724, ogg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (214 residues) CATH domains: Unassigned 1.10.340.30
3fhg
Crystal structure of sulfolobus solfataricus 8-oxoguanine dn glycosylase (ssogg)
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Gene: 1451601, mj0724, ogg, sso0904. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (207 residues) CATH domains: Unassigned 1.10.340.30
3ih7
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmh, mutm, ogg1, ogh1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic DNA. Other_details: synthetic DNA
Chain: A (313 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
3knt
Crystal structure of methanocaldococcus jannaschii 8- oxoguanine glycosylase/lyase in complex with 15mer DNA containing 8-oxoguanine
Source: Methanocaldococcus jannaschii. Methanococcus jannaschii. Organism_taxid: 2190. Gene: 1451601, mj0724, ogg. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans.. Other_details: this sequence occurs naturally in humans.
Chains: A, B, C, D (207 residues) CATH domains: Unassigned 1.10.340.30
3ktu
Structure of human 8-oxoguanine glycosylase 1 bound to fluor oxog-containing DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmh, mutm, ogg1, ogh1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic DNA. Other_details: synthetic DNA
Chain: A (314 residues) CATH domains: 3.30.310.40 1.10.1670.10 1.10.340.30
3n0u
Crystal structure of tm1821, the 8-oxoguanine DNA glycosylas thermotoga maritima
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: ogg, tm1821, tm_1821. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C (209 residues) CATH domains: Unassigned 1.10.340.30
3twk
Crystal structure of arabidopsis thaliana fpg
Source: Arabidopsis thaliana. Mouse-ear cress, thale-cress. Organism_taxid: 3702. Gene: fpg1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (293 residues) CATH domains: 0.0.0.0 0.0.0.0
3twl
Crystal structure of arabidopsis thaliana fpg
Source: Arabidopsis thaliana. Mouse-ear cress, thale-cress. Organism_taxid: 3702. Gene: fpg1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (263 residues) CATH domains: 0.0.0.0 0.0.0.0
3twm
Crystal structure of arabidopsis thaliana fpg
Source: Arabidopsis thaliana. Mouse-ear cress, thale-cress. Organism_taxid: 3702. Gene: fpg1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: purchased from operon technology. Other_details: purchased from operon technology
Chains: A, B (261 residues) CATH domains: 0.0.0.0 0.0.0.0
3u8u
Crystal structure of human apurinic/apyridinimic endonucleas a new crystal form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: apex1, ape, ape1, apex, apx, hap1, ref1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (275 residues) CATH domain: 0.0.0.0
3vk7
Crystal structure of DNA-glycosylase bound to DNA containing hydroxyuracil
Source: Acanthamoeba polyphaga mimivirus. Apmv. Organism_taxid: 212035. Gene: mimi_l315. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chains: A, B (288 residues) CATH domain: 3.20.190.10
3vk8
Crystal structure of DNA-glycosylase bound to DNA containing glycol
Source: Acanthamoeba polyphaga mimivirus. Apmv. Organism_taxid: 212035. Gene: mimi_l315. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
Chains: A, B (288 residues) CATH domain: 3.20.190.10
4iem
Human apurinic/apyrimidinic endonuclease (ape1) with product mg2+
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ape, ape1, apex, apex1, apx, hap1, ref1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic DNA. Organism_taxid: 32630.
Chains: A, B, C, D (278 residues) CATH domain: 0.0.0.0
4lnd
Crystal structure of human apurinic/apyrimidinic endonucleas essential mg2+ cofactor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ape, ape1, apex, apex1, apx, hap1, ref1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (275 residues) CATH domain: 0.0.0.0
4nrv
Crystal structure of non-edited human neil1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: endonuclease viii (nei) 1, neil1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (283 residues) CATH domains: 3.20.190.10 1.10.8.50
4nrw
Mvnei1-g86d
Source: Acanthamoeba polyphaga mimivirus. Apmv. Organism_taxid: 212035. Gene: endonuclease viii (nei) 1, mimi_l315. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
Chains: A, B (285 residues) CATH domain: 3.20.190.10