_EC 4.2.3.50 (+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). 0 PDB entries  
EC 4.-.-.- Lyases. [3,560 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,746 PDB entries]
EC 4.2.3.- Acting on phosphates. [169 PDB entries]
EC 4.2.3.50 (+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). [-]    

Reaction: (2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene.
Comments: The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (see Ec 4.2.3.53) as well as (-)-endo-alpha-bergamotene (see Ec 4.2.3.54).
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There are no PDB entries in enzyme class E.C.4.2.3.50