_EC 4.2.3.38 Alpha-bisabolene synthase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,875 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,909 PDB entries]
EC 4.2.3.- Acting on phosphates. [171 PDB entries]
EC 4.2.3.38 Alpha-bisabolene synthase. [6 PDB entries]    
3sae

Reaction: (2E,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate.
 


(2E,6E)-farnesyl diphosphate
= (E)-alpha-bisabolene
+
diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Cofactor(s): Mg(2+).
Comments: While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use Gdp as a substrate in vitro to produce (+)-(4R)-limonene (cf. Ec 4.2.3.20). Induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding. Formerly Ec 4.2.3.n1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.2.3.38

  PDB code Protein
3sae
Structure of a three-domain sesquiterpene synthase: a prospe target for advanced biofuels production
Source: Abies grandis. Grand fir,lowland fir,lowland white fir,si white fir,yellow fir. Organism_taxid: 46611. Gene: ag1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (780 residues) CATH domains: 1.50.10.130 Unassigned 1.10.600.10
Bound ligand:   Het Group FPS is 51.72% similar to enzyme reactant (2E,6E)-
3sdq
Structure of a three-domain sesquiterpene synthase: a prospe target for advanced biofuels production
Source: Abies grandis. Grand fir,lowland fir,lowland white fir,si white fir,yellow fir. Organism_taxid: 46611. Gene: ag1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (763 residues) CATH domains: 1.50.10.130 Unassigned 1.10.600.10
3sdr
Structure of a three-domain sesquiterpene synthase: a prospe target for advanced biofuels production
Source: Abies grandis. Grand fir,lowland fir,lowland white fir,si white fir,yellow fir. Organism_taxid: 46611. Gene: ag1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (775 residues) CATH domains: 1.50.10.130 Unassigned 1.10.600.10
3sdt
Structure of a three-domain sesquiterpene synthase: a prospe target for advanced biofuels production
Source: Abies grandis. Grand fir,lowland fir,lowland white fir,si white fir,yellow fir. Organism_taxid: 46611. Gene: ag1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (775 residues) CATH domains: 1.50.10.130 Unassigned 1.10.600.10
3sdu
Structure of a three-domain sesquiterpene synthase: a prospe target for advanced biofuels production
Source: Abies grandis. Grand fir,lowland fir,lowland white fir,si white fir,yellow fir. Organism_taxid: 46611. Gene: ag1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (780 residues) CATH domains: 1.50.10.130 Unassigned 1.10.600.10
Bound ligand:   Het Group GST is 40.00% similar to enzyme product diphosphate
3sdv
Structure of a three-domain sesquiterpene synthase: a prospe target for advanced biofuels production
Source: Abies grandis. Grand fir,lowland fir,lowland white fir,si white fir,yellow fir. Organism_taxid: 46611. Gene: ag1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (775 residues) CATH domains: 1.50.10.130 Unassigned 1.10.600.10