_EC 4.2.3.12 6-pyruvoyltetrahydropterin synthase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,772 PDB entries]
EC 4.2.3.- Acting on phosphates. [169 PDB entries]
EC 4.2.3.12 6-pyruvoyltetrahydropterin synthase. [6 PDB entries]    
1b66

Pathway: Biopterin Biosynthesis
Reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + triphosphate.
 

7,8-dihydroneopterin 3'-triphosphate
=
6-pyruvoyl-5,6,7,8- tetrahydropterin
+
triphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 6-pyruvoyl tetrahydrobiopterin synthase. Ptps.
Cofactor(s): Mg(2+).
Comments: Catalyzes triphosphate elimination and an intramolecular redox reaction. The product is 6-pyruvoyltetrahydrobiopterin. Involved in the de novo synthesis of tetrahydrobiopterin from Gtp, with the other enzymes involved being Ec 1.1.1.153 and Ec 3.5.4.16. Formerly Ec 4.6.1.10.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.2.3.12

  PDB code Protein
1b66
6-pyruvoyl tetrahydropterin synthase
Source: Rattus rattus. Black rat. Organism_taxid: 10117. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (138 residues) CATH domain: 3.30.479.10
Bound ligand:   Het Group BIO corresponds to enzyme product 6-pyruvoyl-5,6,7,8-tetrahydropterin
1b6z
6-pyruvoyl tetrahydropterin synthase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116
Chains: A, B (138 residues) CATH domain: 3.30.479.10
1gtq
6-pyruvoyl tetrahydropterin synthase
Source: Rattus rattus. Black rat. Organism_taxid: 10117. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (138 residues) CATH domain: 3.30.479.10
1y13
Structural analysis of plasmodium falciparum 6-pyruvoyl tetrahydropterin synthase (ptps)
Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (163 residues) CATH domain: 3.30.479.10
Bound ligand:   Het Group BIO is 88.24% similar to enzyme product 6-pyruvoyl-5,6,7,8-tetrahydropterin
2g64
Structure of caenorhabditis elegans 6-pyruvoyl tetrahydropte synthase
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: b0041.6. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (140 residues) CATH domain: 3.30.479.10
3i2b
The crystal structure of human 6 pyruvoyl tetrahydrobiopteri
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pts. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, D, E, B, C, F, G, H, I, J, K, L (138 residues) CATH domain: 3.30.479.10