_EC 4.2.3.108 1,8-cineole synthase. 0 PDB entries  
EC 4.-.-.- Lyases. [3,841 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,897 PDB entries]
EC 4.2.3.- Acting on phosphates. [171 PDB entries]
EC 4.2.3.108 1,8-cineole synthase. [-]    

Reaction: Geranyl diphosphate + H(2)O = 1,8-cineole + diphosphate.
 


Geranyl diphosphate
+ H(2)O
=
1,8-cineole
+
diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 1,8-cineole cyclase.
Cofactor(s): Zn(2+) or Mn(2+).
Comments: 1,8-cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)- linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.4.2.3.108