_EC 4.2.3.1 Threonine synthase. 16 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,772 PDB entries]
EC 4.2.3.- Acting on phosphates. [169 PDB entries]
EC 4.2.3.1 Threonine synthase. [16 PDB entries]    
1e5x

Pathway: Threonine Biosynthesis
Reaction: O-phospho-L-homoserine + H(2)O = L-threonine + phosphate.
 


O-phospho-L-homoserine
+ H(2)O
=
L-threonine
+
phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Formerly Ec 4.2.99.2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 16 PDB entries in enzyme class E.C.4.2.3.1

  PDB code Protein
1e5x
Structure of threonine synthase from arabidopsis thaliana
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Organelle: chloroplast. Cellular_location: chloroplast. Plasmid: pet23. Gene: nuclear. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (451 residues) CATH domains: Unassigned 3.40.50.1100
1kl7
Crystal structure of threonine synthase from yeast
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (509 residues) CATH domains: 3.90.1380.10 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1uim
Crystal structure of threonine synthase from thermus thermop orthorhombic crystal form
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (350 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 58.00% similar to enzyme reactant O-phospho-L-homoserine
1uin
Crystal structure of threonine synthase from thermus thermop trigonal crystal form
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (350 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 58.00% similar to enzyme reactant O-phospho-L-homoserine
1uiq
Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
Source: Thermus thermophilus. Bacteria. Gene: hb8. Expressed in: escherichia coli.
Chains: A, B, C, D (351 residues) CATH domains: 3.40.50.1100 3.40.50.1100
1v7c
Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (351 residues) CATH domains: 3.40.50.1100 3.40.50.1100
1v8c
Crystal structure of moad related protein from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (165 residues) CATH domains: 3.10.20.30 3.30.1370.80
1vb3
Crystal structure of threonine synthase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (428 residues) CATH domains: 3.90.1380.10 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group KPA is 42.00% similar to enzyme product L-threonine
2c2b
Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F (445 residues) CATH domains: Unassigned 3.40.50.1100
Bound ligand:   Het Group TRS is 60.00% similar to enzyme product L-threonine
2c2g
Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (448 residues) CATH domains: Unassigned 3.40.50.1100
2d1f
Structure of mycobacterium tuberculosis threonine synthase
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (349 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2zsj
Crystal structure of threonine synthase from aquifex aeolicu
Source: Aquifex aeolicus. Organism_taxid: 63363. Strain: vf5. Gene: thrc2, aq_425. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (350 residues) CATH domains: 3.40.50.1100 3.40.50.1100
3aex
Catalytic intermediate analogue of threonine synthase from t thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: ttha0491. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (351 residues) CATH domains: 3.40.50.1100 3.40.50.1100
3aey
Apo form of threonine synthase from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: ttha0491. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (350 residues) CATH domains: 3.40.50.1100 3.40.50.1100
3v7n
Crystal structure of threonine synthase (thrc) from from bur thailandensis
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264 / atcc 700388 / dsm 13276 / cip 106301. Gene: thrc, bth_i2199. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (464 residues) CATH domains: 3.90.1380.10 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group MLA is 66.67% similar to enzyme product L-threonine
4f4f
X-ray crystal structure of plp bound threonine synthase from melitensis
Source: Brucella melitensis bv. 1. Organism_taxid: 224914. Strain: 16m. Gene: bmei1450, bawg_0773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (464 residues) CATH domains: 3.90.1380.10 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal