_EC 4.2.2.5 Chondroitin Ac lyase. 5 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,772 PDB entries]
EC 4.2.2.- Acting on polysaccharides. [117 PDB entries]
EC 4.2.2.5 Chondroitin Ac lyase. [5 PDB entries]    
1cb8

Reaction: Eliminative degradation of polysaccharides containing 1,4-beta-D- hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.
Other name(s): Chondroitin Ac eliminase. Chondroitin sulfate lyase. Chondroitinase.
Comments: Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of Cs is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1- 3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of Cs may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of
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There are 5 PDB entries in enzyme class E.C.4.2.2.5

  PDB code Protein
1cb8
Chondroitinase ac lyase from flavobacterium heparinum
Source: Pedobacter heparinus. Organism_taxid: 984. Cellular_location: intracellular
Chain: A (675 residues) CATH domains: 1.50.10.100 2.70.98.10 2.60.220.10
1hm2
Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Source: Pedobacter heparinus. Organism_taxid: 984. Expressed in: pedobacter heparinus. Expression_system_taxid: 984
Chain: A (674 residues) CATH domains: 1.50.10.100 2.70.98.10 2.60.220.10
1hm3
Active site of chondroitinase ac lyase revealed by the struc enzyme-oligosaccharide complexes and mutagenesis
Source: Pedobacter heparinus. Organism_taxid: 984. Expressed in: pedobacter heparinus. Expression_system_taxid: 984
Chain: A (674 residues) CATH domains: 1.50.10.100 2.70.98.10 2.60.220.10
1hmu
Active site of chondroitinase ac lyase revealed by the struc enzyme-oligosaccharide complexes and mutagenesis
Source: Pedobacter heparinus. Organism_taxid: 984. Expressed in: pedobacter heparinus. Expression_system_taxid: 984
Chain: A (674 residues) CATH domains: 1.50.10.100 2.70.98.10 2.60.220.10
1hmw
Active site of chondroitinase ac lyase revealed by the struc enzyme-oligosaccharide complexes and mutagenesis
Source: Pedobacter heparinus. Organism_taxid: 984. Expressed in: pedobacter heparinus. Expression_system_taxid: 984
Chain: A (674 residues) CATH domains: 1.50.10.100 2.70.98.10 2.60.220.10