_EC 4.2.1.84 Nitrile hydratase. 28 PDB entries  
EC 4.-.-.- Lyases. [3,613 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,756 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,361 PDB entries]
EC 4.2.1.84 Nitrile hydratase. [28 PDB entries]    
1ahj

Reaction: An aliphatic amide = a nitrile + H(2)O.
 


aliphatic amide
=
nitrile
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Nitrilase. Nitrile hydro-lyase.
Comments: Acts on short-chain aliphatic nitriles, converting them into the corresponding acid amides. Does not act on these amides or on aromatic nitriles (cf. Ec 3.5.5.1).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 28 PDB entries in enzyme class E.C.4.2.1.84

  PDB code Protein
1ahj
Nitrile hydratase
Source: Rhodococcus sp. R312. Organism_taxid: 76275. Organism_taxid: 76275
Chains: A, B, C, D, E, F, G, H (198 residues) CATH domain: 3.90.330.10
1ire
Crystal structure of co-type nitrile hydratase from pseudono thermophila
Source: Pseudonocardia thermophila. Organism_taxid: 1848. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (203 residues) CATH domain: 3.90.330.10
1ugp
Crystal structure of co-type nitrile hydratase complexed with n-butyric acid
Source: Pseudonocardia thermophila. Organism_taxid: 1848. Strain: jcm 3095. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (203 residues) CATH domain: 3.90.330.10
1ugq
Crystal structure of apoenzyme of co-type nitrile hydratase
Source: Pseudonocardia thermophila. Organism_taxid: 1848. Strain: jcm 3095. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (203 residues) CATH domain: 3.90.330.10
1ugr
Crystal structure of at109s mutant of co-type nitrile hydratase
Source: Pseudonocardia thermophila. Organism_taxid: 1848. Strain: jcm 3095. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (203 residues) CATH domain: 3.90.330.10
1ugs
Crystal structure of ay114t mutant of co-type nitrile hydratase
Source: Pseudonocardia thermophila. Organism_taxid: 1848. Strain: jcm 3095. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (203 residues) CATH domain: 3.90.330.10
2ahj
Nitrile hydratase complexed with nitric oxide
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: sp. N-771. Strain: sp. N-771
Chains: A, B, C, D (194 residues) CATH domain: 3.90.330.10
2cyz
Photo-activation state of fe-type nhase in anaerobic condition
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (197 residues) CATH domain: 3.90.330.10
2cz0
Photo-activation state of fe-type nhase in aerobic condition
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (197 residues) CATH domain: 3.90.330.10
2cz1
Photo-activation state of fe-type nhase with n-ba in anaerobic condition
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (196 residues) CATH domain: 3.90.330.10
2cz6
Complex of inactive fe-type nhase with cyclohexyl isocyanide
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (197 residues) CATH domain: 3.90.330.10
2cz7
Fe-type nhase photo-activated for 75min at 105k
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (197 residues) CATH domain: 3.90.330.10
2d0q
Complex of fe-type nhase with cyclohexyl isocyanide, photo- activated for 1hr at 277k
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (192 residues) CATH domain: 3.90.330.10
2qdy
Crystal structure of fe-type nhase from rhodococcus erythrop
Source: Rhodococcus erythropolis. Strain: aj270. Strain: aj270
Chains: A, B (197 residues) CATH domain: 3.90.330.10
2zcf
Mutational study on alpha-gln90 of fe-type nitrile hydratase from rhodococcus sp. N771
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Gene: ntha. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: nthb.
Chains: A, B (198 residues) CATH domain: 3.90.330.10
2zpb
Nitrosylated fe-type nitrile hydratase
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (197 residues) CATH domain: 3.90.330.10
2zpe
Nitrosylated fe-type nitrile hydratase with tert- butylisonitrile
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (196 residues) CATH domain: 3.90.330.10
2zpf
Complex of fe-type nitrile hydratase with tert- butylisonitrile, photo-activated for 18min at 293k
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (196 residues) CATH domain: 3.90.330.10
2zpg
Complex of fe-type nitrile hydratase with tert- butylisonitrile, photo-activated for 120min at 293k
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (196 residues) CATH domain: 3.90.330.10
2zph
Complex of fe-type nitrile hydratase with tert- butylisonitrile, photo-activated for 340min at 293k
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (191 residues) CATH domain: 3.90.330.10
2zpi
Complex of fe-type nitrile hydratase with tert- butylisonitrile, photo-activated for 440min at 293k
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n771. Strain: n771
Chains: A, B (191 residues) CATH domain: 3.90.330.10
3a8g
Crystal structure of nitrile hydratase mutant s113a complexe trimethylacetonitrile
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n-771. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (197 residues) CATH domain: 3.90.330.10
3a8h
Crystal structure of nitrile hydratase mutant s113a complexe trimethylacetamide
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n-771. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (190 residues) CATH domain: 3.90.330.10
3a8l
Crystal structure of photo-activation state of nitrile hydra mutant s113a
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n-771. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (197 residues) CATH domain: 3.90.330.10
3a8m
Crystal structure of nitrile hydratase mutant y72f complexed trimethylacetonitrile
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n-771. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (197 residues) CATH domain: 3.90.330.10
3a8o
Crystal structure of nitrile hydratase complexed with trimethylacetamide
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: n-771. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (197 residues) CATH domain: 3.90.330.10
3vyh
Crystal structure of aw116r mutant of nitrile hydratase from pseudonocardia thermophilla
Source: Pseudonocardia thermophila. Organism_taxid: 1848. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (203 residues) CATH domain: 3.90.330.10
4fm4
Wild type fe-type nitrile hydratase from comamonas testoster
Source: Comamonas testosteroni. Organism_taxid: 285. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P (206 residues) CATH domain: 3.90.330.10