_EC 4.2.1.75 Uroporphyrinogen-III synthase. 8 PDB entries  
EC 4.-.-.- Lyases. [3,649 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,776 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,369 PDB entries]
EC 4.2.1.75 Uroporphyrinogen-III synthase. [8 PDB entries]    
1jr2

Pathway: Porphyrin Biosynthesis (early stages)
Reaction: Hydroxymethylbilane = uroporphyrinogen Iii + H(2)O.
 


Hydroxymethylbilane
=
uroporphyrinogen III
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Hydroxymethylbilane hydro-lyase (cyclizing). Uroporphyrinogen-III cosynthase. Uroporphyrinogen-III cosynthetase.
Comments: In the presence of Ec 2.5.1.61, forms uroporphyrinogen Iii from porphobilinogen.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 8 PDB entries in enzyme class E.C.4.2.1.75

  PDB code Protein
1jr2
Structure of uroporphyrinogen iii synthase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: uros. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (260 residues) CATH domains: 3.40.50.10090 3.40.50.10090
1wcw
Crystal structure of uroporphyrinogen iii synthase from an e thermophilic bacterium thermus thermophilus hb8 (wild type, form-1 crystal)
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (254 residues) CATH domains: 3.40.50.10090 3.40.50.10090
3d8n
Uroporphyrinogen iii synthase-uroporphyringen iii complex
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Gene: tt_c0312. Expressed in: escherichia coli.
Chain: A (250 residues) CATH domains: 3.40.50.10090 3.40.50.10090
Bound ligand:   Het Group UP3 corresponds to enzyme product uroporphyrinogen
3d8r
Thermus thermophilus uroporphyrinogen iii synthase
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Gene: tt_c0312. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (253 residues) CATH domains: 3.40.50.10090 3.40.50.10090
3d8s
Thermus thermophilus uroporphyrinogen iii synthase
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Gene: tt_c0312. Expressed in: escherichia coli.
Chain: A (250 residues) CATH domains: 3.40.50.10090 3.40.50.10090
3d8t
Thermus thermophilus uroporphyrinogen iii synthase
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Gene: tt_c0312. Expressed in: escherichia coli.
Chain: A (252 residues) CATH domains: 3.40.50.10090 3.40.50.10090
3p9z
Crystal structure of uroporphyrinogen-iii synthetase from he pylori 26695
Source: Helicobacter pylori. Organism_taxid: 210. Gene: hp_1224. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domains: Unassigned 3.40.50.10090
4es6
Crystal structure of hemd (pa5259) from pseudomonas aerugino at 2.22 a resolution
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pao1. Gene: hemd, pa5259. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (249 residues) CATH domains: 3.40.50.10090 3.40.50.10090