_EC 4.2.1.70 Pseudouridylate synthase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,920 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,952 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,541 PDB entries]
EC 4.2.1.70 Pseudouridylate synthase. [6 PDB entries]    
1s71

Reaction: Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O.
 


Uracil
+
D-ribose 5-phosphate
=
pseudouridine 5'-phosphate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Pseudouridine synthase. Pseudouridine-5'-phosphate glycosidase. Uracil hydrolyase.
Comments: The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.2.1.70

  PDB code Protein
1s71
Structure of tRNA psi55 pseudouridine synthase (trub)
Source: Mycobacterium tuberculosis. Bacteria. Strain: h37rv. Gene: trub, rv2793c, mt2862.1, mtv002.58c, mb2816c. Expressed in: escherichia coli.
Chains: A, B (262 residues) CATH domains: 3.30.2350.10 2.30.130.10
1vkm
Crystal structure of an indigoidine synthase a (idga)-like p (tm1464) from thermotoga maritima msb8 at 1.90 a resolution
Source: Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Gene: tm1464. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (292 residues) CATH domain: 3.40.1790.10
4gij
Crystal structure of pseudouridine monophosphate glycosidase with sulfate
Source: Escherichia coli. Organism_taxid: 562. Gene: b2165, jw2152, psug, yein. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (304 residues) CATH domain: 3.40.1790.10
4gik
Crystal structure of pseudouridine monophosphate glycosidase r5p adduct
Source: Escherichia coli. Organism_taxid: 562. Gene: b2165, jw2152, psug, yein. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (307 residues) CATH domain: 3.40.1790.10
4gil
Crystal structure of pseudouridine monophosphate glycosidase pseudouridine 5'-phosphate adduct
Source: Escherichia coli. Organism_taxid: 562. Gene: b2165, jw2152, psug, yein. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (307 residues) CATH domain: 3.40.1790.10
4gim
Crystal structure of pseudouridine monophosphate glycosidase with pseudouridine 5'-phosphate
Source: Escherichia coli. Organism_taxid: 562. Gene: b2165, jw2152, psug, yein. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (306 residues) CATH domain: 3.40.1790.10