_EC 4.2.1.22 Cystathionine beta-synthase. 16 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,772 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,376 PDB entries]
EC 4.2.1.22 Cystathionine beta-synthase. [16 PDB entries]    
1jbq

Reaction: L-serine + L-homocysteine = L-cystathionine + H(2)O.
 


L-serine
+
L-homocysteine
=
L-cystathionine
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Beta-thionase. Methylcysteine synthase. Serine sulfhydrase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans. Formerly Ec 4.2.1.21.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 16 PDB entries in enzyme class E.C.4.2.1.22

  PDB code Protein
1jbq
Structure of human cystathionine beta-synthase: a unique pyr phosphate dependent hemeprotein
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (348 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1m54
Cystathionine-beta synthase: reduced vicinal thiols
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Gene: cbs. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F (352 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1wkv
Crystal structure of o-phosphoserine sulfhydrylase
Source: Aeropyrum pernix. Organism_taxid: 272557. Strain: k1. Gene: ape1586. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: Unassigned 3.40.50.1100 3.40.50.1100
Bound ligands:   Het Group ACT is 57.14% similar to enzyme reactant L-serine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3pc2
Full length structure of cystathionine beta-synthase from dr
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg1753, dmel_cg1753. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (500 residues) CATH domains: 3.40.50.1100 3.40.50.1100 3.10.580.10
Bound ligand:   Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
3pc3
Full length structure of cystathionine beta-synthase from dr in complex with aminoacrylate
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg1753, dmel_cg1753. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (504 residues) CATH domains: 3.40.50.1100 3.40.50.1100 3.10.580.10
Bound ligand:   Het Group P1T is 68.00% similar to enzyme cofactor pyridoxal 5'-phosphate
3pc4
Full length structure of cystathionine beta-synthase from dr in complex with serine
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg1753, dmel_cg1753. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (504 residues) CATH domains: 3.40.50.1100 3.40.50.1100 3.10.580.10
Bound ligand:   Het Group KOU is 65.22% similar to enzyme cofactor pyridoxal
3vsa
Crystal structure of o-phosphoserine sulfhydrylase without a
Source: Aeropyrum pernix. Organism_taxid: 272557. Strain: k1. Gene: ape1586, ape_1586, cyso. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: Unassigned 3.40.50.1100 3.40.50.1100
3vsc
Crystal structure of the k127a mutant of o-phosphoserine sul complexed with external schiff base of pyridoxal 5'-phospha phospho-l-serine
Source: Aeropyrum pernix. Organism_taxid: 272557. Strain: k1. Gene: ape1586, ape_1586, cyso. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: Unassigned 3.40.50.1100 3.40.50.1100
3vsd
Crystal structure of the k127a mutant of o-phosphoserine sul complexed with external schiff base of pyridoxal 5'-phospha acetyl-l-serine
Source: Aeropyrum pernix. Organism_taxid: 272557. Strain: k1. Gene: ape1586, ape_1586, cyso. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (382 residues) CATH domains: Unassigned 3.40.50.1100 3.40.50.1100
4coo
Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
Chains: A, B (493 residues) CATH domains: 3.40.50.1100 Unassigned 3.10.580.10
Bound ligands:   Het Group ACT is 57.14% similar to enzyme reactant L-serine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4l0d
Crystal structure of delta516-525 human cystathionine beta-s containing c-terminal 6xhis-tag
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cbs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (496 residues) CATH domains: 3.40.50.1100 3.40.50.1100 3.10.580.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4l27
Crystal structure of delta1-39 and delta516-525 human cystat beta-synthase d444n mutant containing c-terminal 6xhis tag
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cbs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: B, D, A, C (490 residues) CATH domains: 3.40.50.1100 3.40.50.1100 3.10.580.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4l28
Crystal structure of delta516-525 human cystathionine beta-s d444n mutant containing c-terminal 6xhis tag
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cbs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (493 residues) CATH domains: 3.40.50.1100 3.40.50.1100 3.10.580.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4l3v
Crystal structure of delta516-525 human cystathionine beta-s
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cbs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: B, A, C (498 residues) CATH domains: 3.40.50.1100 3.40.50.1100 3.10.580.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4ofx
Crystal structure of a putative cystathionine beta-synthase coxiella burnetii
Source: Coxiella burnetii. Organism_taxid: 227377. Strain: rsa 493 / nine mile phase i. Gene: cbu_2024. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (288 residues) CATH domain: 3.40.50.1100
4uuu
1.7 a resolution structure of human cystathionine beta-synth regulatory domain (del 516-525) in complex with sam
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B (137 residues)
Bound ligand:   Het Group SAM is 41.38% similar to enzyme product L-cystathionine