_EC 4.2.1.20 Tryptophan synthase. 84 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,772 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,376 PDB entries]
EC 4.2.1.20 Tryptophan synthase. [84 PDB entries]    
1a50

Pathway: Tryptophan Biosynthesis
Reaction: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O.
 


L-serine
+
1-C-(indol-3-yl)glycerol 3-phosphate
=
L-tryptophan
+
D-glyceraldehyde 3-phosphate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Indoleglycerol phosphate aldolase. L-tryptophan synthetase. Tryptophan desmolase. Tryptophan synthetase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: The alpha-subunit catalyzes the conversion of 1-C-(indol-3- yl)glycerol 3-phosphate to indole and D-glyceraldehyde 3-phosphate (this reaction was listed formerly as Ec 4.1.2.8). The indole migrates to the beta-subunit where, in the presence of pyridoxal 5'-phosphate, it is combined with L-serine to form L-tryptophan. In some organisms this enzyme is part of a multifunctional protein that also includes one or more of the enzymes Ec 2.4.2.18, Ec 4.1.1.48, Ec 4.1.3.27 and Ec 5.3.1.24. In thermophilic organisms, where the high temperature enhances
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 84 PDB entries in enzyme class E.C.4.2.1.20

  PDB code Protein
1a50
Crystal structure of wild-type tryptophan synthase complexed fluoroindole propanol phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Plasmid: pstb7. Plasmid: pstb7
Chains: A, B (260 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group FIP is 85.00% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1a5a
Cryo-crystallography of a true substrate, indole-3-glycerol bound to a mutant (alphad60n) tryptophan synthase alpha2bet reveals the correct orientation of active site alpha glu 49
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: cb149.
Chains: A, B (255 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1a5b
Cryo-crystallography of a true substrate, indole-3-glycerol bound to a mutant (alpha d60n) tryptophan synthase alpha2be complex reveals the correct orientation of active site alph
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: cb149.
Chains: A, B (249 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IGP corresponds to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1a5s
Crystal structure of wild-type tryptophan synthase complexed fluoroindole propanol phosphate and l-ser bound as amino ac the beta site
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group SER is 85.71% similar to enzyme reactant L-serine
  Het Group FIP is 85.00% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1beu
Trp synthase (d60n-ipp-ser) with k+
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: cb149.
Chains: A, B (253 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IPL is 89.00% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
  Het Group PLS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1bks
Tryptophan synthase (E.C.4.2.1.20) from salmonella typhimuri
Source: Salmonella typhimurium. Organism_taxid: 602. Strain: tb2211. Gene: trpa/trpb/trpc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (255 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1c29
Crystal structure of the complex of bacterial tryptophan syn the transition state analogue inhibitor 4-(2-hydroxyphenylt butenylphosphonic acid
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1c8v
Crystal structure of the complex of bacterial tryptophan syn the transition state analogue inhibitor 4-(2-hydroxyphenylt butylphosphonic acid
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (264 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1c9d
Crystal structure of the complex of bacterial tryptophan syn the transition state analogue inhibitor 4-(2-hydroxy-4- fluorophenylthio)-butylphosphonic acid
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1cw2
Crystal structure of the complex of bacterial tryptophan syn the transition state analogue inhibitor 4-(2-hydroxyphenyls butylphosphonic acid
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1cx9
Crystal structure of the complex of bacterial tryptophan syn the transition state analogue inhibitor 4-(2-aminophenylthi butylphosphonic acid
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1fuy
Crystal structure of betaa169l/betac170w double mutant of tr synthase complexed with 5-fluoro-indole-propanol phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group FIP is 85.00% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1geq
Entropic stabilization of the tryptophan synthase a-subunit hyperthermophile, pyrococcus furiosus: x-ray analysis and c
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (241 residues) CATH domain: 3.20.20.70
1k3u
Crystal structure of wild-type tryptophan synthase complexed [1h-indol-3-yl-acetyl]aspartic acid
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (268 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IAD is 50.00% similar to enzyme product L-tryptophan
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1k7e
Crystal structure of wild-type tryptophan synthase complexed [1h-indol-3-yl-acetyl]glycine acid
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (261 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IAG is 60.00% similar to enzyme product L-tryptophan
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1k7f
Crystal structure of wild-type tryptophan synthase complexed [1h-indol-3-yl-acetyl]valine acid
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (253 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IAV is 52.17% similar to enzyme product L-tryptophan
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1k7x
Crystal structure of the beta-ser178pro mutant of tryptophan
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (254 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1k8x
Crystal structure of alphat183v mutant of tryptophan synthas salmonella typhimurium
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 99287. Strain: lt2.
Chains: A, B (249 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1k8y
Crystal structure of the tryptophan synthase beta-ser178pro complexed with d,l-alpha-glycerol-3-phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (255 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group 13P corresponds to enzyme product glyceraldehyde
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1k8z
Crystal structure of the tryptophan synthase beta-ser178pro complexed with n-[1h-indol-3-yl-acetyl]glycine acid
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IAG is 60.00% similar to enzyme product L-tryptophan
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1kfb
Crystal structure of alphat183v mutant of tryptophan synthas salmonella typhimurium with indole glycerol phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (255 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IGP corresponds to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1kfc
Crystal structure of alphat183v mutant of tryptophan synthas salmonella typhimurium with indole propanol phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 99287. Strain: lt2. Expression_system_taxid: 562
Chains: A, B (254 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IPL is 89.47% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1kfe
Crystal structure of alphat183v mutant of tryptophan synthas salmonella typhimurium with l-ser bound to the beta site
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 99287. Strain: lt2.
Chains: A, B (252 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLS is 65.22% similar to enzyme cofactor pyridoxal
1kfj
Crystal structure of wild-type tryptophan synthase complexed with l-serine
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (253 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1kfk
Crystal structure of tryptophan synthase from salmonella typ
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 99287. Strain: lt2.
Chains: A, B (251 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1qop
Crystal structure of wild-type tryptophan synthase complexed with indole propanol phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb.
Chains: A, B (265 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IPL is 89.47% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1qoq
Crystal structure of wild-type tryptophan synthase complexed with indole glycerol phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb.
Chains: A, B (254 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IGP corresponds to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1rd5
Crystal structure of tryptophan synthase alpha chain homolog member of the chemical plant defense system
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (261 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group MLA is 75.00% similar to enzyme reactant L-serine
1tjp
Crystal structure of wild-type tryptophan synthase complexed [(2-hydroxylphenyl)amino]3-glycerolphosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa, stm1727. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb, stm1726, sty1325, t1638. Expression_system_taxid: 562
Chains: A, B (267 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group PLP is 54.55% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group HPF is 78.95% similar to enzyme cofactor pyridoxal
1tjr
Crystal structure of wild-type bx1 complexed with a sulfate ion
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (261 residues) CATH domain: 3.20.20.70
1ttp
Tryptophan synthase (E.C.4.2.1.20) in the presence of cesium temperature
Source: Salmonella typhimurium. Organism_taxid: 602. Strain: tb2211. Gene: trpa/trpb/trpc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (256 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1ttq
Tryptophan synthase (E.C.4.2.1.20) in the presence of potass room temperature
Source: Salmonella typhimurium. Organism_taxid: 602. Strain: tb2211. Gene: trpa/trpb/trpc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (256 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1ubs
Tryptophan synthase (E.C.4.2.1.20) with a mutation of lys 87 the b subunit and in the presence of ligand l-serine
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group SER corresponds to enzyme reactant L-serine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1ujp
Crystal structure of tryptophan synthase a-subunit from ther thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (243 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group CIT is 42.86% similar to enzyme reactant L-serine
1v7y
Crystal structure of tryptophan synthase alpha-subunit from escherichia coli at room temperature
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (248 residues) CATH domain: 3.20.20.70
1v8z
X-ray crystal structure of the tryptophan synthase b2 subuni hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (386 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1wbj
Wildtype tryptophan synthase complexed with glycerol phosphate
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (267 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group G3P corresponds to enzyme product glyceraldehyde 3-phosphate
  Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1wdw
Structural basis of mutual activation of the tryptophan synt complex from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (241 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1wq5
Crystal structure of tryptophan synthase alpha-subunit from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group GOL is 62.50% similar to enzyme reactant L-serine
1wxj
Crystal structure of tryptophan synthase a-subunit with indo propanol phosphate from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (239 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IPL is 89.47% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
1x1q
Crystal structure of tryptophan synthase beta chain from the thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (385 residues) CATH domains: 3.40.50.1100 3.40.50.1100
1xc4
Crystal structure of wild-type tryptophan synthase alpha-sub escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (240 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group GOL is 62.50% similar to enzyme reactant L-serine
1xcf
Crystal structure of p28l/y173f tryptophan synthase alpha- subunits from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (238 residues) CATH domain: 3.20.20.70
2cle
Tryptophan synthase in complex with n-(4'- trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (f6) - lowf6 complex
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 602
Chains: A, B (252 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2clf
Tryptophan synthase in complex with n-(4'- trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (f6) - highf6 complex
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (253 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2clh
Tryptophan synthase in complex with (naphthalene-2'- sulfonyl)-2-amino-1-ethylphosphate (f19)
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 602
Chains: A, B (259 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2cli
Tryptophan synthase in complex with n-(4'- trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (f9)
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2clk
Tryptophan synthase in complex with d-glyceraldehyde 3- phosphate (g3p)
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group G3H corresponds to enzyme product glyceraldehyde 3-phosphate
  Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2cll
Tryptophan synthase (external aldimine state) in complex with n-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1- ethylphosphate (f9)
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2clm
Tryptophan synthase (external aldimine state) in complex with n-(4'-trifluoromethoxybenzoyl)-2-amino-1- ethylphosphate (f6f)
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (252 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2clo
Tryptophan synthase (external aldimine state) in complex with (naphthalene-2'-sulfonyl)-2-amino-1-ethylphosphate (f19)
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2dh5
Crystal structure of e. Coli holo-trpb
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (393 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligands:   Het Group GOL is 62.50% similar to enzyme reactant L-serine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2dh6
Crystal structure of e. Coli apo-trpb
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (331 residues) CATH domains: 3.40.50.1100 3.40.50.1100
2dzp
Structure of mutant tryptophan synthase alpha-subunit (d17n) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2dzs
Structure of mutant tryptophan synthase alpha-subunit (e103a) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2dzt
Structure of mutant tryptophan synthase alpha-subunit (d110a) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2dzu
Structure of mutant tryptophan synthase alpha-subunit (d110n) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2dzv
Structure of mutant tryptophan synthase alpha-subunit (d146a) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2dzw
Structure of mutant tryptophan synthase alpha-subunit (e244a) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2dzx
Structure of mutant tryptophan synthase alpha-subunit (e131- 132a) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2e09
Structure of mutant tryptophan synthase alpha-subunit (e74a) from a hyperthermophile, pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (244 residues) CATH domain: 3.20.20.70
2ekc
Structural study of project id aq_1548 from aquifex aeolicus
Source: Aquifex aeolicus. Organism_taxid: 224324. Strain: vf5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (253 residues) CATH domain: 3.20.20.70
2j9x
Tryptophan synthase in complex with gp, alpha-d,l-glycerol- phosphate, cs, ph6.5 - alpha aminoacrylate form - (gp)e(a- a)
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group G3P corresponds to enzyme product glyceraldehyde 3-phosphate
  Het Group P1T is 68.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2j9y
Tryptophan synthase q114n mutant in complex with compound ii
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (252 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FOO is 68.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2j9z
Tryptophan synthase t110 mutant complex
Source: Salmonella typhimurium. Organism_taxid: 602. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (252 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2o2e
Mycobacterium tuberculosis tryptophan synthase beta subunit (apoform)
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (315 residues) CATH domains: 3.40.50.1100 3.40.50.1100
2o2j
Mycobacterium tuberculosis tryptophan synthase beta chain dimer (apoform)
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: trpb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (315 residues) CATH domains: 3.40.50.1100 3.40.50.1100
2rh9
Tryptophan synthase complexed with igp, internal aldimine, p
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa, stm1727. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb, stm1726.
Chains: A, B (254 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IGP corresponds to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2rhg
Tryptophan synthase complexed with igp, ph 7.0, internal ald
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb.
Chains: A, B (250 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IGP corresponds to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2trs
Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: cb149.
Chains: A, B (262 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IPL is 89.00% similar to enzyme reactant (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
  Het Group PLS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2tsy
Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: cb149.
Chains: A, B (262 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group G3P corresponds to enzyme product glyceraldehyde 3-phosphate
  Het Group PLS is 65.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2tys
Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Gene: trpa/trpb. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: cb149.
Chains: A, B (255 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLT is 50.00% similar to enzyme product L-tryptophan
2wsy
Crystal structure of wild-type tryptophan synthase
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: cb149. Plasmid: pstb7. Plasmid: pstb7
Chains: A, B (237 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3cep
Structure of a tryptophan synthase quinonoid intermediate
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb.
Chains: A, B (266 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group MH6 is 85.71% similar to enzyme reactant L-serine
  Het Group IDM is 60.00% similar to enzyme product L-tryptophan
  Het Group G3P corresponds to enzyme product glyceraldehyde
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3nav
Crystal structure of an alpha subunit of tryptophan synthase vibrio cholerae o1 biovar el tor str. N16961
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (261 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group EDO is 40.00% similar to enzyme product glyceraldehyde 3-phosphate
3pr2
Tryptophan synthase indoline quinonoid structure with f9 inh alpha site
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 90371. Gene: stm1727, trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: stm1726, trpb.
Chains: A, B (266 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group 7MN is 48.39% similar to enzyme cofactor pyridoxal
3tha
Tryptophan synthase subunit alpha from campylobacter jejuni.
Source: Campylobacter jejuni. Organism_taxid: 192222. Strain: subsp. Jejuni nctc 11168. Gene: cj0349, trpa. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (248 residues) CATH domain: 3.20.20.70
3vnd
Crystal structure of tryptophan synthase alpha-subunit from psychrophile shewanella frigidimarina k14-2
Source: Shewanella frigidimarina. Organism_taxid: 56812. Strain: k14-2. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (259 residues) CATH domain: 3.20.20.70
4hn4
Tryptophan synthase in complex with alpha aminoacrylate e(a- and the f9 inhibitor in the alpha site
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 90371. Gene: stm1727, trpa, trpa and trpb. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 90371
Chains: A, B (268 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group 0JO is 68.18% similar to enzyme cofactor pyridoxal
4hpj
Crystal structure of tryptophan synthase at 1.45 a resolutio complex with 2-aminophenol quinonoid in the beta site and t inhibitor in the alpha site
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 90371. Gene: stm1727, trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: stm1726, trpb.
Chains: A, B (268 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group 1D0 is 50.00% similar to enzyme cofactor pyridoxal
4hpx
Crystal structure of tryptophan synthase at 1.65 a resolutio complex with alpha aminoacrylate e(a-a) and benzimidazole i site and the f9 inhibitor in the alpha site
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 90371. Gene: stm1727, trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: stm1726, trpb.
Chains: A, B (268 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group 0JO is 68.18% similar to enzyme cofactor pyridoxal
4ht3
The crystal structure of salmonella typhimurium tryptophan s 1.30a complexed with n-(4'-trifluoromethoxybenzenesulfonyl) 1-ethylphosphate (f9) inhibitor in the alpha site, internal
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 90371. Gene: stm1727, trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: stm1726, trpb.
Chains: A, B (268 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4kkx
Crystal structure of tryptophan synthase from salmonella typ with 2-aminophenol quinonoid in the beta site and the f6 in the alpha site
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 90371. Gene: trpa. Expression_system_taxid: 562. Expression_system_cell_line: cb149. Gene: trpb.
Chains: A, B (268 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group EDO is 40.00% similar to enzyme product D-glyceraldehyde
  Het Group AQ3 is 50.00% similar to enzyme cofactor pyridoxal
4neg
The crystal structure of tryptophan synthase subunit beta fr bacillus anthracis str. 'Ames ancestor'
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 261594. Strain: ames ancestor. Gene: bacillus anthracis, bas1161, ba_1253, gbaa_1253, trpb expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (322 residues) CATH domains: 3.40.50.1100 3.40.50.1100
Bound ligand:   Het Group GOL is 62.50% similar to enzyme reactant L-serine