_EC 4.2.1.2 Fumarate hydratase. 22 PDB entries  
EC 4.-.-.- Lyases. [3,764 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,840 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,430 PDB entries]
EC 4.2.1.2 Fumarate hydratase. [22 PDB entries]    
1fuo

Pathway: Citric acid cycle
Reaction: (S)-malate = fumarate + H(2)O.
 


(S)-malate
=
fumarate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Fumarase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 22 PDB entries in enzyme class E.C.4.2.1.2

  PDB code Protein
1fuo
FumarasE C with bound citrate
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group MLT corresponds to enzyme reactant (S)-malate
1fup
Fumarase with bound pyromellitic acid
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (455 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group MLT corresponds to enzyme reactant (S)-malate
1fuq
Fumarase with bound 3-trimethylsilylsuccinic acid
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligands:   Het Group CIT is 69.23% similar to enzyme reactant (S)-malate
  Het Group SIF is 66.67% similar to enzyme product fumarate
1fur
Fumarase mutant h188n with bound substrate l-malate at putat activator site
Source: Escherichia coli. Organism_taxid: 562. Strain: jm105. Cell_line: 293. Cellular_location: cytoplasm. Gene: fumc. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: site-directed mutant of fumarasE C was gener
Chains: A, B (456 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group MLT corresponds to enzyme reactant (S)-malate
1kq7
E315q mutant form of fumarasE C from e.Coli
Source: Escherichia coli. Organism_taxid: 562. Gene: fumc. Expressed in: escherichia coli k12. Expression_system_taxid: 83333.
Chains: A, B (456 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group MLT corresponds to enzyme reactant (S)-malate
1vdk
Crystal structure of fumarase from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (458 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
1vpj
Crystal structure of fumarase (fum-1) (np_069927.1) from archaeoglobus fulgidus at 1.69 a resolution
Source: Archaeoglobus fulgidus dsm 4304. Bacteria. Gene: fum-1. Expressed in: escherichia coli.
Chains: A, B (178 residues) CATH domain: 3.20.130.10
1yfe
Crystal structure of apo fumarasE C from escherichia coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12
Chain: A (457 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
1yfm
Recombinant yeast fumarase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fum1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (450 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
2fus
Mutations of fumarase that distinguish between the active si nearby dicarboxylic acid binding site
Source: Escherichia coli. Organism_taxid: 562. Strain: jm105. Cell_line: 293. Cellular_location: cytoplasm. Gene: fumc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group CIT is 69.23% similar to enzyme reactant (S)-malate
3e04
Crystal structure of human fumarate hydratase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (456 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group EDO is 44.44% similar to enzyme reactant (S)-malate
3gtd
2.4 angstrom crystal structure of fumarate hydratase from ri prowazekii
Source: Rickettsia prowazekii. Organism_taxid: 272947. Strain: madrid-e. Gene: fumc, rp665. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (455 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group MLI is 60.00% similar to enzyme reactant (S)-malate
3no9
Crystal structure of apo fumarate hydratase from mycobacteri tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: fum, fumc, mt1130, mtv017.51c, rv1098c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (453 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
3qbp
Crystal structure of fumarase fum from mycobacterium marinum
Source: Mycobacterium marinum. Organism_taxid: 216594. Strain: atcc baa-535 / m. Gene: fum, mmar_4368. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (441 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
3rd8
Crystal structure of fumarate hydratase class ii mycobacteri smegmatis
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: atcc 700084 / mc(2)155. Gene: msmeg_5240. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (457 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
3rrp
Crystal structure of fumarate hydratase fum from mycobacteri abscessus with malate bound
Source: Mycobacterium abscessus. Organism_taxid: 561007. Strain: atcc 19977 / dsm 44196. Gene: mab_1250c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (465 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
3tv2
Structure of a class ii fumarate hydratase from burkholderia pseudomallei
Source: Burkholderia pseudomallei. Organism_taxid: 320372. Strain: 1710b. Gene: fumc, burps1710b_2940. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (457 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
4adl
Crystal structures of rv1098c in complex with malate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (459 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group LMR corresponds to enzyme reactant (S)-malate
4adm
Crystal structure of rv1098c in complex with meso-tartrate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (450 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group SRT is 90.00% similar to enzyme reactant (S)-malate
4apa
Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318a in apo form
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (440 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
4apb
Crystal structure of mycobacterium tuberculosis fumarase ( rv1098c) s318c in complex with fumarate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (460 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30
Bound ligand:   Het Group FUM corresponds to enzyme product fumarate
4hgv
Crystal structure of a fumarate hydratase
Source: Sinorhizobium meliloti. Organism_taxid: 266834. Strain: 1021. Gene: fumc, r01859, smc00149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (456 residues) CATH domains: 1.10.275.10 1.20.200.10 1.10.40.30