_EC 4.2.1.129 Squalene--hopanol cyclase. 7 PDB entries  
EC 4.-.-.- Lyases. [1,436 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [707 PDB entries]
EC 4.2.1.- Hydro-lyases. [522 PDB entries]
EC 4.2.1.129 Squalene--hopanol cyclase. [7 PDB entries]    
1h35

Reaction: Hopan-22-ol = squalene + H(2)O.
 


Hopan-22-ol
=
squalene
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Squalene--hopene cyclase.
Comments: The enzyme produces the cyclization products hopene (cf. Ec 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.4.2.1.129

  PDB code Protein
1h35
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
Bound ligand:   Het Group R01 is 52.63% similar to enzyme reactant Hopan-22-ol
1h36
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h37
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h3c
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1o6h
Squalene-hopene cyclase
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1o79
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
2sqc
Squalene-hopene cyclase from alicyclobacillus acidocaldarius
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Cell_line: jm105. Atcc: atcc 27009. Collection: atcc 27009. Cellular_location: membrane. Expressed in: escherichia coli k12. Expression_system_taxid: 83333. Expression_system_cell_line: jm105.
Chains: A, B (623 residues) CATH domains: 1.50.10.20 1.50.10.20