_EC 4.2.1.129 Squalene--hopanol cyclase. 16 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,772 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,376 PDB entries]
EC 4.2.1.129 Squalene--hopanol cyclase. [16 PDB entries]    
1gsz

Reaction: Hopan-22-ol = squalene + H(2)O.
 


Hopan-22-ol
=
squalene
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Squalene--hopene cyclase.
Comments: The enzyme produces the cyclization products hopene (cf. Ec 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 16 PDB entries in enzyme class E.C.4.2.1.129

  PDB code Protein
1gsz
Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug ro48-8071
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h35
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
Bound ligand:   Het Group R01 is 52.63% similar to enzyme reactant Hopan-22-ol
1h36
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h37
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h39
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h3a
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h3b
Squalene-hopene cyclase
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1h3c
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1o6h
Squalene-hopene cyclase
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1o6q
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1o6r
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1o79
Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
1sqc
Squalene-hopene-cyclase from alicyclobacillus acidocaldarius
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Cell_line: jm105. Atcc: 27009. Cellular_location: membrane. Expressed in: escherichia coli k12. Expression_system_taxid: 83333. Expression_system_cell_line: jm105. Other_details: thermostable, acidophilic
Chain: A (619 residues) CATH domains: 1.50.10.20 1.50.10.20
1ump
Geometry of triterpene conversion to pentacarbocyclic hopene
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Atcc: 27009. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: jm105. Other_details: thermostable, acidophilic
Chains: A, B, C (620 residues) CATH domains: 1.50.10.20 1.50.10.20
Bound ligand:   Het Group SQA is 81.82% similar to enzyme product Squalene
2sqc
Squalene-hopene cyclase from alicyclobacillus acidocaldarius
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Cell_line: jm105. Atcc: atcc 27009. Collection: atcc 27009. Cellular_location: membrane. Expressed in: escherichia coli k12. Expression_system_taxid: 83333. Expression_system_cell_line: jm105.
Chains: A, B (623 residues) CATH domains: 1.50.10.20 1.50.10.20
3sqc
Squalene-hopene cyclase
Source: Alicyclobacillus acidocaldarius. Organism_taxid: 405212. Cell_line: jm105. Atcc: atcc 27009. Collection: atcc 27009. Cellular_location: membrane. Expressed in: escherichia coli k12. Expression_system_taxid: 83333. Expression_system_cell_line: jm105.
Chains: A, B, C (619 residues) CATH domains: 1.50.10.20 1.50.10.20