_EC 4.2.1.110 Aldos-2-ulose dehydratase. 3 PDB entries  
EC 4.-.-.- Lyases. [3,613 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,755 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,359 PDB entries]
EC 4.2.1.110 Aldos-2-ulose dehydratase. [3 PDB entries]    
4a7k

Reaction: (1) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2- ulose + H(2)O. (2) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2- (hydroxymethyl)-2H-pyran-3(6H)-one.
 


1,5-anhydro-D-fructose
= 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2- ulose
+ H(2)O
1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose
= 2-hydroxy-2- (hydroxymethyl)-2H-pyran-3(6H)-one
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 1,5-anhydro-D-fructose dehydratase (microthecin-forming). Audh. Pyranosone dehydratase.
Comments: This enzyme catalyzes two of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose. Aldose-2-uloses such as 2-dehydroglucose can also act as substrates, but more slowly. This is a bifunctional enzyme that acts as both a lyase and as an isomerase. Differs from Ec 4.2.1.111, which can carry out only reaction 1, is inhibited by its product and requires metal ions for activity.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 3 PDB entries in enzyme class E.C.4.2.1.110

  PDB code Protein
4a7k
Bifunctional aldos-2-ulose dehydratase
Source: Phanerochaete chrysosporium. White rot fungus. Organism_taxid: 5306. Expressed in: ogataea angusta. Expression_system_taxid: 870730.
Chain: A (879 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligand:   Het Group GOL is 54.55% similar to enzyme reactant 1,5-anhydro-D-fructose
4a7y
Active site metal depleted aldos-2-ulose dehydratase
Source: Phanerochaete chrysosporium. White rot fungus. Organism_taxid: 5306. Expressed in: ogataea angusta. Expression_system_taxid: 870730.
Chain: A (880 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligand:   Het Group NHF corresponds to enzyme reactant 1,5-anhydro-D-fructose
4a7z
Complex of bifunctional aldos-2-ulose dehydratase with the r intermediate ascopyrone m
Source: Phanerochaete chrysosporium. White rot fungus. Organism_taxid: 5306. Expressed in: ogataea angusta. Expression_system_taxid: 870730.
Chain: A (881 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligand:   Het Group AY9 is 90.91% similar to enzyme reactant 1,5-anhydro-D-fructose