_EC 4.2.1.106 Bile-acid 7-alpha-dehydratase. 4 PDB entries  
EC 4.-.-.- Lyases. [3,615 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [1,754 PDB entries]
EC 4.2.1.- Hydro-lyases. [1,358 PDB entries]
EC 4.2.1.106 Bile-acid 7-alpha-dehydratase. [4 PDB entries]    
4l8o

Reaction: 7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate = 12-alpha-hydroxy-3- oxochola-4,6-dienoate + H(2)O.
 


7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate
=
12-alpha-hydroxy-3- oxochola-4,6-dienoate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): BA7 alpha dehydratase.
Comments: The enzyme from Eubacterium sp. strain Vpi 12708 can also use 7-alpha-hydroxy-3-oxochol-4-enoate as a substrate but not 7-alpha,12- alpha-dihydroxy-3-oxochol-5-beta-anoate, 3-alpha,7-alpha,12-alpha- trihydroxychol-5-beta-anoate or 7-beta-hydroxy-3-oxochol-4-enoate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.4.2.1.106

  PDB code Protein
4l8o
Crystal structure of a bile-acid 7-alpha dehydratase (clohyl from clostridium hylemonae dsm 15053 at 2.20 a resolution
Source: Clostridium hylemonae dsm 15053. Organism_taxid: 553973. Gene: baie, clohylem_06634. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (165 residues) CATH domain: 3.10.450.50
4l8p
Crystal structure of a bile-acid 7-alpha dehydratase (clohir from clostridium hiranonis dsm 13275 at 1.60 a resolution
Source: Clostridium hiranonis dsm 13275. Organism_taxid: 500633. Gene: baie, clohir_00079. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (168 residues) CATH domain: 3.10.450.50
4leh
Crystal structure of a bile-acid 7-alpha dehydratase (closci from clostridium scindens atcc 35704 at 2.90 a resolution
Source: Clostridium scindens. Organism_taxid: 411468. Atcc: 35704. Gene: baie, closci_03134. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (167 residues) CATH domain: 3.10.450.50
4n3v
Crystal structure of a bile-acid 7-alpha dehydratase (clohir from clostridium hiranonis dsm 13275 at 1.89 a resolution w product added
Source: Clostridium hiranonis. Organism_taxid: 500633. Strain: dsm 13275. Gene: baie, clohir_00079. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (167 residues) CATH domain: 3.10.450.50