_EC 4.1.99.3 Deoxyribodipyrimidine photo-lyase. 19 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,239 PDB entries]
EC 4.1.99.- Other carbon-carbon lyases. [75 PDB entries]
EC 4.1.99.3 Deoxyribodipyrimidine photo-lyase. [19 PDB entries]    
1dnp

Pathway: EC 4.1.99.3
Reaction: Cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).
 


Cyclobutadipyrimidine (in DNA)
= 2 × pyrimidine residues (in DNA)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Dna photolyase. Photoreactivating enzyme.
Cofactor(s): 5,10-methenyltetrahydrofolate; Fad.
 

5,10-methenyltetrahydrofolate

FAD
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: A flavoprotein containing a second chromophore group. Catalyzes the reactivation by light of irradiated Dna. A similar reactivation of irradiated rna is probably due to a separate enzyme.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 19 PDB entries in enzyme class E.C.4.1.99.3

  PDB code Protein
1dnp
Structure of deoxyribodipyrimidine photolyase
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (469 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligands:   Het Group MHF corresponds to enzyme cofactor 5,10- methenyltetrahydrofolate
  Het Group FAD corresponds to enzyme cofactor FAD
1iqr
Crystal structure of DNA photolyase from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (415 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1iqu
Crystal structure of photolyase-thymine complex
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (415 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1owl
Structure of apophotolyase from anacystis nidulans
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (473 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1owm
Data1:dna photolyase / received x-rays dose 1.2 exp15 photon
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (474 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1own
Data3:dna photolyase / received x-rays dose 4.8 exp15 photon
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (474 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1owo
Data4:photoreduced DNA photolyase / received x-rays dose 1.2 photons/mm2
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (474 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1owp
Data6:photoreduced DNA pholyase / received x-rays dose 4.8 e photons/mm2
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (474 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1qnf
Structure of photolyase
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (475 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1tez
Complex between DNA and the DNA photolyase from anacystis ni
Source: Synthetic: yes. Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Cellular_location: cytoplasm. Gene: phr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (474 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligands:   Het Group C is 44.74% similar to enzyme reactant Cyclobutadipyrimidine
  Het Group FAD corresponds to enzyme cofactor FAD
2e0i
Crystal structure of archaeal photolyase from sulfolobus tok two fad molecules: implication of a novel light-harvesting
Source: Sulfolobus tokodaii. Organism_taxid: 273063. Strain: 7. Gene: st0889. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (428 residues) CATH domains: 3.40.50.620 Unassigned 1.10.579.10
2j07
Thermus DNA photolyase with 8-hdf antenna chromophore
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm)
Chain: A (419 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2j08
Thermus DNA photolyase with 8-iod-riboflavin antenna chromophore
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm)
Chain: A (419 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligands:   Het Group IRF is 46.51% similar to enzyme reactant Cyclobutadipyrimidine
  Het Group FAD corresponds to enzyme cofactor FAD
2j09
Thermus DNA photolyase with fmn antenna chromophore
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm)
Chain: A (419 residues) CATH domains: 3.40.50.620 1.25.40.80 1.10.579.10
Bound ligands:   Het Group FMN is 42.55% similar to enzyme reactant Cyclobutadipyrimidine
  Het Group FAD corresponds to enzyme cofactor FAD
2xry
X-ray structure of archaeal class ii cpd photolyase from methanosarcina mazei
Source: Methanosarcina mazei. Organism_taxid: 192952. Strain: go1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold.
Chain: A (458 residues) CATH domains: 3.40.50.620 1.25.40.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2xrz
X-ray structure of archaeal class ii cpd photolyase from methanosarcina mazei in complex with intact cpd-lesion
Source: Methanosarcina mazei. Organism_taxid: 192952. Strain: go1. Expression_system_variant: gold. Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Organism_taxid: 32630
Chains: A, B (450 residues) CATH domains: 3.40.50.620 1.25.40.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3umv
Eukaryotic class ii cpd photolyase structure reveals a basis improved uv-tolerance in plants
Source: Oryza sativa japonica group. Japanese rice. Organism_taxid: 39947. Gene: phr, os10g0167600, loc_os10g08580, osjnab0015j03.12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (472 residues) CATH domains: 3.40.50.620 1.25.40.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4cdm
Crystal structure of m. Mazei photolyase soaked with synthetic 8-hdf
Source: Methanosarcina mazei. Organism_taxid: 192952. Strain: go1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold.
Chain: A (454 residues) CATH domains: 3.40.50.620 1.25.40.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4cdn
Crystal structure of m. Mazei photolyase with its in vivo reconstituted 8-hdf antenna chromophore
Source: Methanosarcina mazei. Organism_taxid: 192952. Strain: go1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold.
Chains: A, B (463 residues) CATH domains: 3.40.50.620 1.25.40.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD