_EC 4.1.99.2 Tyrosine phenol-lyase. 11 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,237 PDB entries]
EC 4.1.99.- Other carbon-carbon lyases. [75 PDB entries]
EC 4.1.99.2 Tyrosine phenol-lyase. [11 PDB entries]    
1c7g

Reaction: L-tyrosine + H(2)O = phenol + pyruvate + NH(3).
 


L-tyrosine
+ H(2)O
=
phenol
+
pyruvate
+ NH(3)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Beta-tyrosinase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also slowly catalyzes pyruvate formation from D-tyrosine, S-methyl-L- cysteine, L-cysteine, L-serine and D-serine.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.4.1.99.2

  PDB code Protein
1c7g
Tyrosine phenol-lyase from erwinia herbicola
Source: Pantoea agglomerans pv. Gypsophilae. Organism_taxid: 48984. Strain: pv. Gypsophilae. Variant: aj2985. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: tna deficient. Other_details: recombinant gene
Chains: A, B, C, D (456 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1tpl
The three-dimensional structure of tyrosine phenol-lyase
Source: Citrobacter intermedius. Organism_taxid: 66695
Chains: A, B (426 residues) CATH domains: 3.90.1150.10 3.40.640.10
2ez1
Holo tyrosine phenol-lyase from citrobacter freundii at ph 8
Source: Citrobacter freundii. Organism_taxid: 546. Gene: tpl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (455 residues) CATH domains: 3.90.1150.10 3.40.640.10
2ez2
Apo tyrosine phenol-lyase from citrobacter freundii at ph 8.
Source: Citrobacter freundii. Organism_taxid: 546. Gene: tpl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: 3.90.1150.10 3.40.640.10
2tpl
Tyrosine phenol-lyase from citrobacter intermedius complex w hydroxyphenyl)propionic acid, pyridoxal-5'-phosphate and cs
Source: Citrobacter freundii. Organism_taxid: 546
Chains: A, B (455 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group HPP is 92.31% similar to enzyme reactant L-tyrosine
2vlf
Quinonoid intermediate of citrobacter freundii tyrosine phenol-lyase formed with alanine
Source: Citrobacter freundii. Organism_taxid: 546. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLI is 68.18% similar to enzyme cofactor pyridoxal
2vlh
Quinonoid intermediate of citrobacter freundii tyrosine phenol-lyase formed with methionine
Source: Citrobacter freundii. Organism_taxid: 546. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PM9 is 60.00% similar to enzyme cofactor pyridoxal
2ycn
Y71f mutant of tyrosine phenol-lyase from citrobacter freund complex with quinonoid intermediate formed with 3-fluoro-l-
Source: Citrobacter freundii. Organism_taxid: 546. Atcc: 13316. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group PEG is 44.44% similar to enzyme product pyruvate
  Het Group P61 is 50.00% similar to enzyme cofactor pyridoxal
2ycp
F448h mutant of tyrosine phenol-lyase from citrobacter freun complex with quinonoid intermediate formed with 3-fluoro-l-
Source: Citrobacter freundii. Organism_taxid: 546. Atcc: 13316. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (456 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group EDO is 66.67% similar to enzyme product pyruvate
  Het Group P61 is 50.00% similar to enzyme cofactor pyridoxal
2yct
Tyrosine phenol-lyase from citrobacter freundii in complex w pyridine n-oxide and the quinonoid intermediate formed with l-alanine
Source: Citrobacter freundii. Organism_taxid: 546. Atcc: 13316. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (455 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2yhk
D214a mutant of tyrosine phenol-lyase from citrobacter freun
Source: Citrobacter freundii. Organism_taxid: 546. Atcc: 13316. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (455 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group PEG is 44.44% similar to enzyme product pyruvate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal