_EC 4.1.99.14 Spore photoproduct lyase. 0 PDB entries  
EC 4.-.-.- Lyases. [3,640 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,236 PDB entries]
EC 4.1.99.- Other carbon-carbon lyases. [75 PDB entries]
EC 4.1.99.14 Spore photoproduct lyase. [-]    

Reaction: (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double-helical DNA) = thymidylyl-(3'->5')-thymidylate (in double-helical DNA).
 

(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double-helical DNA)
+
S-adenosyl-L-methionine
= thymidylyl-(3'->5')-thymidylate (in double- helical DNA)
+
5'-deoxyadenosine
+
L-methionine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Sp lyase.
Cofactor(s): Iron-sulfur; S-adenosyl-L-methionine.
 

Iron-sulfur

S-adenosyl-L-methionine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme binds a [4Fe-4S] cluster. The cluster is coordinated by 3 cysteines and an exchangeable Sam molecule. The 5'-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion. During the second part of the repair process the Sam molecule is regenerated.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.4.1.99.14