_EC 4.1.3.4 Hydroxymethylglutaryl-CoA lyase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,239 PDB entries]
EC 4.1.3.- Oxo-acid-lyases. [145 PDB entries]
EC 4.1.3.4 Hydroxymethylglutaryl-CoA lyase. [6 PDB entries]    
1ydn

Pathway: Mevalonate Biosynthesis
Reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.
 


(S)-3-hydroxy-3-methylglutaryl-CoA
=
acetyl-CoA
+
acetoacetate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase. 3-hydroxy-3-methylglutarate-CoA lyase. HMG-CoA lyase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.1.3.4

  PDB code Protein
1ydn
Crystal structure of the hmg-coa lyase from brucella meliten northeast structural genomics target lr35.
Source: Brucella melitensis. Organism_taxid: 224914. Strain: 16m. Gene: geneid:1197637. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (283 residues) CATH domain: 3.20.20.70
1ydo
Crystal structure of the bacillis subtilis hmg-coa lyase, no structural genomics target sr181.
Source: Bacillus subtilis subsp. Subtilis. Organism_taxid: 224308. Strain: 168. Gene: yngg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (298 residues) CATH domain: 3.20.20.70
2cw6
Crystal structure of human hmg-coa lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (296 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group 3HG is 70.00% similar to enzyme product acetoacetate
3mp3
Crystal structure of human lyase in complex with inhibitor h
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (296 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group HGG is 98.00% similar to enzyme reactant (S)-3-hydroxy-3-methylglutaryl-CoA
  Het Group 3HG is 70.00% similar to enzyme product acetoacetate
3mp4
Crystal structure of human lyase r41m mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (296 residues) CATH domain: 3.20.20.70
3mp5
Crystal structure of human lyase r41m in complex with hmg-co
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (296 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group HMG corresponds to enzyme reactant (S)-3-hydroxy-3-methylglutaryl-CoA