_EC 4.1.3.38 Aminodeoxychorismate lyase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,237 PDB entries]
EC 4.1.3.- Oxo-acid-lyases. [145 PDB entries]
EC 4.1.3.38 Aminodeoxychorismate lyase. [6 PDB entries]    
1et0

Pathway: Folate Biosynthesis (late stages)
Reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.
 


4-amino-4-deoxychorismate
=
4-aminobenzoate
+
pyruvate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 4-amino-4-deoxychorismate lyase. 4-amino-4-deoxychorismate pyruvate-lyase. Adc lyase. Enzyme X.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Forms part of the folate biosynthesis pathway. Acts on 4-amino-4-deoxychorismate, the product of Ec 2.6.1.85, to form p-aminobenzoate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.1.3.38

  PDB code Protein
1et0
Crystal structure of aminodeoxychorismate lyase from escheri
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (254 residues) CATH domains: 3.30.470.10 3.20.10.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1i2k
Aminodeoxychorismate lyase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Gene: pabc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.470.10 3.20.10.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1i2l
Deoxychorismate lyase from escherichia coli with inhibitor
Source: Escherichia coli. Organism_taxid: 562. Gene: pabc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.470.10 3.20.10.10
Bound ligand:   Het Group DCS is 65.22% similar to enzyme cofactor pyridoxal
2xpf
Crystal structure of putative aminodeoxychorismate lyase from pseudomonas aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pao1. Atcc: 47085. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (270 residues) CATH domains: 3.30.470.10 3.20.10.10
Bound ligands:   Het Group PEG is 44.00% similar to enzyme product pyruvate
  Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2y1u
Crystal structure of aminodeoxychorismate lyase from pseudomonas aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pao1. Atcc: 47085. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: american type culture collection (atcc)
Chains: A, B (270 residues) CATH domains: 3.30.470.10 3.20.10.10
Bound ligands:   Het Group GOL is 71.00% similar to enzyme product pyruvate
  Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
4k6n
Crystal structure of yeast 4-amino-4-deoxychorismate lyase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: s288c. Gene: abz2, ymr289w. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (352 residues) CATH domains: Unassigned 3.20.10.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal