_EC 4.1.3.36 1,4-dihydroxy-2-naphthoyl-CoA synthase. 15 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,237 PDB entries]
EC 4.1.3.- Oxo-acid-lyases. [145 PDB entries]
EC 4.1.3.36 1,4-dihydroxy-2-naphthoyl-CoA synthase. [15 PDB entries]    
1q51

Pathway: Vitamin K Biosynthesis
Reaction: 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O.
 

4-(2-carboxyphenyl)-4-oxobutanoyl-CoA
=
1,4-dihydroxy-2-naphthoyl-CoA
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Dhna synthetase. Dihydroxynaphthoic acid synthetase. Naphthoate synthase. o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing).
Comments: This enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1) in plants), and many plant pigments. The coenzyme A group is subsequently removed from the product by Ec 3.1.2.28.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 15 PDB entries in enzyme class E.C.4.1.3.36

  PDB code Protein
1q51
Crystal structure of mycobacterium tuberculosis menb in comp acetoacetyl-coenzyme a, a key enzyme in vitamin k2 biosynth
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: menb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (271 residues) CATH domains: 3.90.226.10 1.10.12.10
Bound ligand:   Het Group CAA is 87.10% similar to enzyme product 1,4-dihydroxy-2-naphthoyl-CoA
1q52
Crystal structure of mycobacterium tuberculosis menb, a key vitamin k2 biosynthesis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (269 residues) CATH domains: 3.90.226.10 1.10.12.10
1rjm
Crystal structure of menb (rv0548c) from mycobacterium tuber
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: menb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (239 residues) CATH domain: 3.90.226.10
1rjn
The crystal structure of menb (rv0548c) from mycobacterium tuberculosis in complex with the coa portion of naphthoyl c
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: menb (rv0548c). Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (259 residues) CATH domain: 3.90.226.10
Bound ligand:   Het Group COA is 62.90% similar to enzyme product 1,4-dihydroxy-2-naphthoyl-CoA
2iex
Crystal structure of dihydroxynapthoic acid synthetase (gk28 geobacillus kaustophilus hta426
Source: Geobacillus kaustophilus. Organism_taxid: 235909. Strain: hta426. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (253 residues) CATH domains: 3.90.226.10 1.10.12.10
2uzf
Crystal structure of staphylococcus aureus 1,4-dihydroxy-2- naphthoyl coa synthase (menb) in complex with acetoacetyl coa
Source: Staphylococcus aureus. Organism_taxid: 1280. Atcc: 35556. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (260 residues) CATH domains: 3.90.226.10 1.10.12.10
Bound ligand:   Het Group CAA is 87.10% similar to enzyme product 1,4-dihydroxy-2-naphthoyl-CoA
3h02
2.15 angstrom resolution crystal structure of naphthoate syn salmonella typhimurium.
Source: Salmonella typhimurium. Organism_taxid: 602. Strain: lt2. Gene: menb, stm2307. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (266 residues) CATH domains: 3.90.226.10 1.10.12.10
3t88
Crystal structure of escherichia coli menb in complex with s analogue, osb-ncoa
Source: Escherichia coli. Organism_taxid: 562. Gene: b2262. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (281 residues) CATH domains: 3.90.226.10 1.10.12.10
Bound ligand:   Het Group S0N is 60.26% similar to enzyme product 1,4-dihydroxy-2-naphthoyl-CoA
3t89
Crystal structure of escherichia coli menb, the 1,4-dihydrox naphthoyl-coa synthase in vitamin k2 biosynthesis
Source: Escherichia coli. Organism_taxid: 562. Gene: b2262. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (270 residues) CATH domains: 3.90.226.10 1.10.12.10
3t8a
Crystal structure of mycobacterium tuberculosis menb in comp substrate analogue, osb-ncoa
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv0548c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (253 residues) CATH domain: 3.90.226.10
Bound ligand:   Het Group S0N is 64.52% similar to enzyme product 1,4-dihydroxy-2-naphthoyl-CoA
3t8b
Crystal structure of mycobacterium tuberculosis menb with al hexameric assembly
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv0548c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (237 residues) CATH domain: 3.90.226.10
4els
Structure of e. Coli. 1,4-dihydroxy-2- naphthoyl coenzyme a (menb) in complex with bicarbonate
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: menb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (267 residues) CATH domains: 3.90.226.10 1.10.12.10
4elw
Structure of e. Coli. 1,4-dihydroxy-2- naphthoyl coenzyme a (menb) in complex with nitrate
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: menb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (267 residues) CATH domains: 3.90.226.10 1.10.12.10
4elx
Structure of apo e.Coli. 1,4-dihydroxy-2- naphthoyl coa synt cl
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: menb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (268 residues) CATH domains: 3.90.226.10 1.10.12.10
4i42
E.Coli. 1,4-dihydroxy-2-naphthoyl coenzyme a synthase (ecmen complex with 1-hydroxy-2-naphthoyl-coa
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b2262, jw2257, menb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (285 residues) CATH domains: 3.90.226.10 1.10.12.10
Bound ligand:   Het Group 1HA is 98.39% similar to enzyme product 1,4-dihydroxy-2-naphthoyl-CoA