_EC 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase. 7 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,239 PDB entries]
EC 4.1.3.- Oxo-acid-lyases. [145 PDB entries]
EC 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase. [7 PDB entries]    
1j3l

Reaction: (1) 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. (2) 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate.
 


4-hydroxy-4-methyl-2-oxoglutarate
=
2 × pyruvate

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
=
oxaloacetate
+
pyruvate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 4-carboxy-4-hydroxy-2-oxoadipate aldolase. 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. Cha aldolase. Hmg aldolase.
Cofactor(s): Divalent cation.
Comments: This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), phthalate, syringate and gallate. The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2- oxoglutarate to glyoxylate and pyruvate, and also catalyzes the reaction of Ec 4.1.1.3.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.4.1.3.17

  PDB code Protein
1j3l
Structure of the RNA-processing inhibitor rraa from thermus thermophilis
Source: Thermus thermophilus. Organism_taxid: 274. Strain: hd8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (164 residues) CATH domain: 3.50.30.40
1nxj
Structure of rv3853 from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: meng. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (156 residues) CATH domain: 3.50.30.40
1vi4
Crystal structure of regulator of ribonuclease acivity a protein 1
Source: Vibrio cholerae. Organism_taxid: 666. Gene: rraa1, vc2366. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (162 residues) CATH domain: 3.50.30.40
2c5q
Crystal structure of yeast yer010cp
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (233 residues) CATH domain: Unassigned
2pcn
Crystal structure of s-adenosylmethionine: 2-dimethylmenaqui methyltransferase (gk_1813) from geobacillus kaustophilus h
Source: Geobacillus kaustophilus. Organism_taxid: 235909. Strain: hta426. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (161 residues) CATH domain: 3.50.30.40
3c8o
The crystal structure of rraa from pao1
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Strain: k-12. Gene: rraa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (160 residues) CATH domain: 3.50.30.40
3noj
The structure of hmg/cha aldolase from the protocatechuate d pathway of pseudomonas putida
Source: Pseudomonas putida. Organism_taxid: 351746. Strain: f1. Gene: pput1361, pput_1361. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (235 residues) CATH domain: 3.50.30.40