_EC 4.1.2.25 Dihydroneopterin aldolase. 25 PDB entries  
EC 4.-.-.- Lyases. [3,615 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,243 PDB entries]
EC 4.1.2.- Aldehyde-lyases. [287 PDB entries]
EC 4.1.2.25 Dihydroneopterin aldolase. [25 PDB entries]    
1dhn

Pathway: Folate Biosynthesis (late stages)
Reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
 

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine
=
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
+
glycolaldehyde
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine glycolaldehyde-lyase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 25 PDB entries in enzyme class E.C.4.1.2.25

  PDB code Protein
1dhn
1.65 angstrom resolution structure of 7,8-dihydroneopterin a from staphylococcus aureus
Source: Staphylococcus aureus. Organism_taxid: 1280. Atcc: atcc 25923. Collection: atcc 25923. Gene: dhna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (121 residues) CATH domain: 3.30.1130.10
1nbu
7,8-dihydroneopterin aldolase complexed with product from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: folb or rv3607c or mt3712.1 or mtcy07h7b.15. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H (118 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group PH2 corresponds to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1r7k
Tetrameric structure of apo-7,8-dihydroneopterin aldolase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Bacteria. Strain: h37rv. Gene: folb, rv3607c, mt3712.1, mtcy07h7b.15, mb3637c. Expressed in: escherichia coli.
Chain: A (108 residues) CATH domain: 3.30.1130.10
1rr5
Dhna 7,8 dihydroneopterin complex
Source: Staphylococcus aureus. Bacteria. Gene: folb. Expressed in: escherichia coli.
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group NPR is 77.00% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1rri
Dhna complex with 3-(5-amino-7-hydroxy-[1,2,3] triazolo [4,5 d]pyrimidin-2-yl)-benzoic acid
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group A45 is 41.67% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1rrw
Dhna complexed with 9-methylguanine
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group 9MG is 85.71% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1rry
Dhna complexed with 2-amino-4-hydroxy-5-carboxyethylpyrimidi
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group 204 is 42.11% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1rs2
Dhna complex with 8-amino-1,3-dimethyl-3,7-dihydropurine-2,6
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group 209 is 64.71% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1rs4
Dhna, 7,8-dihydroneopterin aldolase complexed with 3-(5-amin hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-n-(3,5-dichlo benzamide
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
1rsd
Dhna complex with 3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5- d]pyrimidin-2-yl)-n-[2-(2-hydroxymethyl-phenylsulfanyl)-ben benzamide
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
1rsi
Dhna complex with 2-amino-5-bromo-3-hydroxy-6-phenylpyrimidi
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
1sql
Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Strain: m15[prep4]
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P (120 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group GUN is 78.00% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1u68
Dhna 7,8 dihydroneopterin complex
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group NPR is 77.78% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1z9w
Tetrameric structure of apo-7,8-dihydroneopterin aldolase fr mycobacterium tuberculosis
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (108 residues) CATH domain: 3.30.1130.10
2bmb
X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (513 residues) CATH domains: 3.30.70.560 3.20.20.20
Bound ligand:   Het Group PMM is 77.00% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
2cg8
The bifunctional dihydroneopterin aldolase 6-hydroxymethyl- 7,8-dihydropterin synthase from streptococcus pneumoniae
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (241 residues) CATH domains: 3.30.1130.10 3.30.70.560
2dhn
Complex of 7,8-dihydroneopterin aldolase from staphylococcus with 6-hydroxymethyl-7,8-dihydropterin at 2.2 a resolution
Source: Staphylococcus aureus. Organism_taxid: 1280. Atcc: atcc 25923. Collection: atcc 25923. Gene: dhna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group PH2 corresponds to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
2i52
Crystal structure of protein pto0218 from picrophilus torrid duf372
Source: Picrophilus torridus. Organism_taxid: 263820. Strain: dsm 9790. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (115 residues) CATH domain: 3.30.1300.20
2iec
Crystal structure of uncharacterized conserved archael protein from methanopyrus kandleri
Source: Methanopyrus kandleri. Organism_taxid: 2320. Gene: q8tx89_metka, mk0786. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (113 residues) CATH domain: 3.30.1300.20
2nm2
Crystal structure of dihydroneopterin aldolase from s. Aureu complex with (1s,2r)-neopterin at 1.50 angstrom resolution
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (121 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group NEU is 77.78% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
2nm3
Crystal structure of dihydroneopterin aldolase from s. Aureu complex with (1s,2s)-monapterin at 1.68 angstrom resolution
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: folb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (121 residues) CATH domain: 3.30.1130.10
Bound ligands:   Het Group MPU is 77.78% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group ACT is 60.00% similar to enzyme product Glycolaldehyde
2o90
Atomic resolution crystal structure of e.Coli dihydroneopterin aldolase in complex with neopterin
Source: Escherichia coli. Organism_taxid: 562. Gene: folb. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (115 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group NEU is 77.00% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
2o9m
Crystal structure of e.Coli dihydroneopterin aldolase in complex with 6-hydroxymethyl-7,8-dihydropterin
Source: Escherichia coli. Gene: folb. Expressed in: escherichia coli.
Chains: A, B, C, D, E, F, G, H (120 residues) CATH domain: 3.30.1130.10
Bound ligand:   Het Group PH2 corresponds to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
2ogf
Crystal structure of protein mj0408 from methanococcus janna pfam duf372
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Gene: mj0408. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (121 residues) CATH domain: 3.30.1300.20
3r2e
Dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-e from yersinia pestis.
Source: Yersinia pestis. Organism_taxid: 632. Strain: co-92. Gene: folb, ypo0648. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (117 residues) CATH domain: 3.30.1130.10