_EC 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase. 14 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,239 PDB entries]
EC 4.1.2.- Aldehyde-lyases. [277 PDB entries]
EC 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase. [14 PDB entries]    
1eua

Reaction: 2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
 

2-dehydro-3-deoxy-6-phosphate-D-gluconate
=
pyruvate
+
D-glyceraldehyde 3-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate- lyase. 2-keto-3-deoxy-6-phosphogluconate aldolase. KDPG-aldolase. Phospho-2-dehydro-3-deoxygluconate aldolase. Phospho-2-keto-3-deoxygluconate aldolase.
Comments: The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. Ec 4.1.2.55). Also acts on 2-oxobutanoate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.4.1.2.14

  PDB code Protein
1eua
Schiff base intermediate in kdpg aldolase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B, C (213 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PYR corresponds to enzyme product pyruvate
1eun
Structure of 2-keto-3-deoxy-6-phosphogluconate aldolase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B, C (213 residues) CATH domain: 3.20.20.70
1fq0
Kdpg aldolase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (213 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group CIT is 46.00% similar to enzyme product pyruvate
1fwr
Crystal structure of kdpg aldolase double mutant k133q/t161k
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (213 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group CIT is 46.00% similar to enzyme product pyruvate
1kga
Structure of 2-keto-3-deoxy-6-phosphogluconate aldolase at 2.8 angstroms resolution
Source: Pseudomonas putida. Organism_taxid: 303
Chain: A (173 residues)
1mxs
Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg from pseudomonas putida.
Source: Pseudomonas putida. Organism_taxid: 303
Chain: A (216 residues) CATH domain: 3.20.20.70
1vhc
Crystal structure of a putative khg/kdpg aldolase
Source: Haemophilus influenzae. Organism_taxid: 727. Gene: eda, hi0047. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (212 residues) CATH domain: 3.20.20.70
1wau
Structure of kdpg aldolase e45n mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (213 residues) CATH domain: 3.20.20.70
1wbh
Crystal structure of the e45n mutant from kdpg aldolase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (213 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product D-glyceraldehyde 3-phosphate
2c0a
Mechanism of the class i kdpg aldolase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (213 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product D-glyceraldehyde
2r91
Crystal structure of kd(p)ga from t.Tenax
Source: Thermoproteus tenax. Organism_taxid: 2271. Gene: kdga. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, D, B, C (286 residues) CATH domain: 3.20.20.70
2r94
Crystal structure of kd(p)ga from t.Tenax
Source: Thermoproteus tenax. Organism_taxid: 2271. Strain: kdga. Gene: kdga. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, D, B, C (286 residues) CATH domain: 3.20.20.70
3nzr
Crystal structure of 2-dehydro-3-deoxyphosphogluconate aldol vibrio fischeri es114
Source: Vibrio fischeri. Organism_taxid: 312309. Strain: es114. Gene: vf_2509. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (245 residues) CATH domain: 3.20.20.70
4bk9
Crystal structure of 2-keto-3-deoxy-6-phospho-gluconate aldolase from zymomonas mobilis atcc 29191
Source: Zymomonas mobilis. Organism_taxid: 542. Atcc: 29191. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (207 residues) CATH domain: 3.20.20.70