_EC 4.1.1.81 Threonine-phosphate decarboxylase. 4 PDB entries  
EC 4.-.-.- Lyases. [3,919 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,284 PDB entries]
EC 4.1.1.- Carboxy-lyases. [744 PDB entries]
EC 4.1.1.81 Threonine-phosphate decarboxylase. [4 PDB entries]    
1lc5

Pathway: Corrin Biosynthesis (part 6)
Reaction: L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO(2).
 


L-threonine O-3-phosphate
=
(R)-1-aminopropan-2-yl phosphate
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-threonine O-3-phosphate carboxy-lyase. L-threonine-O-3-phosphate decarboxylase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Unable to decarboxylate the D-isomer of threonine O-3-phosphate. The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of Ec 6.3.1.10, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.4.1.1.81

  PDB code Protein
1lc5
Crystal structure of l-threonine-o-3-phosphate decarboxylase enterica in its apo state
Source: Salmonella enterica. Organism_taxid: 28901. Gene: cobd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (355 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product (R)-1-aminopropan-2-yl
1lc7
Crystal structure of l-threonine-o-3-phosphate decarboxylase enterica complexed with a substrate
Source: Salmonella enterica. Organism_taxid: 28901. Gene: cobd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (358 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group TPO corresponds to enzyme reactant L-threonine
1lc8
Crystal structure of l-threonine-o-3-phosphate decarboxylase enterica complexed with its reaction intermediate
Source: Salmonella enterica. Organism_taxid: 28901. Gene: cobd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (356 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group 33P is 60.00% similar to enzyme cofactor pyridoxal
1lkc
Crystal structure of l-threonine-o-3-phosphate decarboxylase salmonella enterica
Source: Salmonella enterica. Organism_taxid: 28901. Gene: cobd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (355 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group EDO is 40.00% similar to enzyme product CO(2)
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal