_EC 4.1.1.74 Indolepyruvate decarboxylase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,613 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,243 PDB entries]
EC 4.1.1.- Carboxy-lyases. [735 PDB entries]
EC 4.1.1.74 Indolepyruvate decarboxylase. [6 PDB entries]    
1ovm

Reaction: 3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
 


3-(indol-3-yl)pyruvate
=
2-(indol-3-yl)acetaldehyde
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 3-(indol-3-yl)pyruvate carboxy-lyase. Indol-3-yl-pyruvate carboxy-lyase. Indole-3-pyruvate decarboxylase.
Cofactor(s): Magnesium; Thiamine diphosphate.
 
Magnesium

Thiamine diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: More specific than Ec 4.1.1.1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.1.1.74

  PDB code Protein
1ovm
Crystal structure of indolepyruvate decarboxylase from enterobacter cloacae
Source: Enterobacter cloacae. Organism_taxid: 550. Gene: ipdc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (535 residues) CATH domains: 3.40.50.970 3.40.50.1220 3.40.50.970
Bound ligand:   Het Group TPP corresponds to enzyme cofactor Thiamine diphosphate
2nxw
Crystal structure of phenylpyruvate decarboxylase of azospir brasilense
Source: Azospirillum brasilense. Organism_taxid: 192. Gene: ipdc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (537 residues) CATH domains: 3.40.50.970 3.40.50.1220 3.40.50.970
Bound ligand:   Het Group TPP corresponds to enzyme cofactor Thiamine
2q5j
X-ray structure of phenylpyruvate decarboxylase in complex w deaza-thdp
Source: Azospirillum brasilense. Organism_taxid: 192. Gene: ipdc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (523 residues) CATH domains: 3.40.50.970 3.40.50.1220 3.40.50.970
Bound ligand:   Het Group TPW is 44.44% similar to enzyme cofactor Thiamine
2q5l
X-ray structure of phenylpyruvate decarboxylase in complex w hydroxyethyl)-3-deaza-thdp
Source: Azospirillum brasilense. Organism_taxid: 192. Gene: ipdc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (538 residues) CATH domains: 3.40.50.970 3.40.50.1220 3.40.50.970
Bound ligand:   Het Group S1T is 41.03% similar to enzyme cofactor Thiamine
2q5o
X-ray structure of phenylpyruvate decarboxylase in complex w deaza-thdp and phenylpyruvate
Source: Azospirillum brasilense. Organism_taxid: 192. Gene: ipdc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (529 residues) CATH domains: 3.40.50.970 3.40.50.1220 3.40.50.970
Bound ligands:   Het Group PPY is 80.00% similar to enzyme reactant (indol-3-yl)pyruvate
  Het Group TPW is 44.44% similar to enzyme cofactor Thiamine
2q5q
X-ray structure of phenylpyruvate decarboxylase in complex w deaza-thdp and 5-phenyl-2-oxo-valeric acid
Source: Azospirillum brasilense. Organism_taxid: 192. Gene: ipdc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (533 residues) CATH domains: 3.40.50.970 3.40.50.1220 3.40.50.970
Bound ligands:   Het Group KPV is 81.25% similar to enzyme reactant (indol-3-yl)pyruvate
  Het Group TPW is 44.44% similar to enzyme cofactor Thiamine