_EC 4.1.1.50 Adenosylmethionine decarboxylase. 33 PDB entries  
EC 4.-.-.- Lyases. [3,636 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,239 PDB entries]
EC 4.1.1.- Carboxy-lyases. [742 PDB entries]
EC 4.1.1.50 Adenosylmethionine decarboxylase. [33 PDB entries]    
1i72

Pathway: Spermine Biosynthesis
Reaction: S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2).
 


S-adenosyl-L-methionine
= S-adenosyl 3-(methylthio)propylamine
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): S-adenosyl-L-methionine carboxy-lyase. S-adenosyl-L-methionine decarboxylase.
Cofactor(s): Pyruvate.
 

Pyruvate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 33 PDB entries in enzyme class E.C.4.1.1.50

  PDB code Protein
1i72
Human s-adenosylmethionine decarboxylase with covalently bou pyruvoyl group and covalently bound 5'-deoxy-5'-[n-methyl-n aminooxyethyl) amino]adenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: B, A (61 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group MAO is 54.00% similar to enzyme reactant S-adenosyl-L-methionine
1i79
Human s-adenosylmethionine decarboxylase with covalently bou pyruvoyl group and covalently bound 5'-deoxy-5'-[(3-hydrazi methylamino]adenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: B, A (61 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group MHZ is 52.00% similar to enzyme reactant S-adenosyl-L-methionine
1i7b
Human s-adenosylmethionine decarboxylase with covalently bou pyruvoyl group and covalently bound s-adenosylmethionine me
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: B, A (61 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group SMM is 96.00% similar to enzyme reactant S-adenosyl-L-methionine
1i7c
Human s-adenosylmethionine decarboxylase with covalently bou pyruvoyl group and complexed with methylglyoxal bis-(guanyl
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: B, A (61 residues) CATH domain: 3.30.360.50
1i7m
Human s-adenosylmethionine decarboxylase with covalently bou pyruvoyl group and complexed with 4-amidinoindan-1-one-2'- amidinohydrazone
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: B, A, D, C (57 residues) CATH domain: 3.30.360.50
1jen
Human s-adenosylmethionine decarboxylase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: B, A, D, C (57 residues) CATH domain: 3.30.360.50
1jl0
Structure of a human s-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the h243a mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (310 residues) CATH domain: 3.60.90.10
Bound ligand:   Het Group TRS is 40.00% similar to enzyme cofactor pyruvate
1mhm
Crystal structure of s-adenosylmethionine decarboxylase from potato
Source: Solanum tuberosum. Potato. Organism_taxid: 4113. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (54 residues) CATH domain: 3.30.360.50
1msv
The s68a s-adenosylmethionine decarboxylase proenzyme processing mutant.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (319 residues) CATH domain: 3.60.90.10
Bound ligand:   Het Group TRS is 40.00% similar to enzyme cofactor pyruvate
1tlu
Crystal structure of thermotoga maritima s- adenosylmethionine decarboxylase
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: speh, tm0655. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (117 residues) CATH domain: 3.60.90.10
1tmi
Structure of thermotoga maritima s63a non-processing mutant s-adenosylmethionine decarboxylase
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: speh, tm0655. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (117 residues) CATH domain: 3.60.90.10
1vr7
Crystal structure of s-adenosylmethionine decarboxylase proe (tm0655) from thermotoga maritima at 1.2 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0655. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (120 residues) CATH domain: 3.60.90.10
Bound ligand:   Het Group EDO is 66.67% similar to enzyme cofactor pyruvate
2iii
Crystal structure of the adenosylmethionine decarboxylase (a from aquifex aeolicus vf5
Source: Aquifex aeolicus. Organism_taxid: 224324. Strain: vf5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (120 residues) CATH domain: 3.60.90.10
3dz2
Human adometdc with 5'-[(3-aminopropyl)methylamino]-5'deoxy- 8-methyladenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (60 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group A8M is 52.00% similar to enzyme reactant S-adenosyl-L-methionine
3dz3
Human adometdc f223a mutant with covalently bound s- adenosylmethionine methyl ester
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (61 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group SMM is 96.00% similar to enzyme reactant S-adenosyl-L-methionine
3dz4
Human adometdc with 5'-[(2-carboxamidoethyl)methylamino]-5'- deoxy-8-methyladenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (61 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group C8M is 51.00% similar to enzyme reactant S-adenosyl-L-methionine
3dz5
Human adometdc with covalently bound 5'-[(2-aminooxyethyl) methylamino]-5'-deoxy-8-methyladenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (55 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group M8M is 52.00% similar to enzyme reactant S-adenosyl-L-methionine
3dz6
Human adometdc with 5'-[(4-aminooxybutyl)methylamino]- 5'deoxy-8-ethyladenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (56 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group M8E is 48.00% similar to enzyme reactant S-adenosyl-L-methionine
3dz7
Human adometdc with 5'-[(carboxamidomethyl)methylamino]-5'- deoxy-8-methyladenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (61 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group O8M is 52.00% similar to enzyme reactant S-adenosyl-L-methionine
3ep3
Human adometdc d174n mutant with no putrescine bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (54 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3ep4
Human adometdc e256q mutant with no putrescine bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (56 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3ep5
Human adometdc e178q mutant with no putrescine bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (57 residues) CATH domain: 3.30.360.50
Bound ligands:   Het Group URE is 40.00% similar to enzyme product CO(2)
  Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3ep6
Human adometdc d174n mutant complexed with s- adenosylmethionine methyl ester and no putrescine bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (57 residues) CATH domain: 3.30.360.50
Bound ligands:   Het Group SMM is 96.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group PYR is 66.00% similar to enzyme cofactor pyruvate
3ep7
Human adometdc e256q mutant complexed with s- adenosylmethionine methyl ester and no putrescine bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (57 residues) CATH domain: 3.30.360.50
Bound ligands:   Het Group SMM is 96.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group PYR is 66.00% similar to enzyme cofactor pyruvate
3ep8
Human adometdc e178q mutant complexed with s- adenosylmethionine methyl ester and no putrescine bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (57 residues) CATH domain: 3.30.360.50
Bound ligands:   Het Group SMM is 96.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group PYR is 66.00% similar to enzyme cofactor pyruvate
3ep9
Human adometdc with no putrescine bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (56 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3epa
Human adometdc e178q mutant complexed with putrescine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (54 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3epb
Human adometdc e256q mutant complexed with putrescine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (55 residues) CATH domain: 3.30.360.50
Bound ligand:   Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3h0v
Human adometdc with 5'-deoxy-5'-(dimethylsulfonio) adenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (58 residues) CATH domain: 3.30.360.50
Bound ligands:   Het Group M2T is 77.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3h0w
Human adometdc with 5'-deoxy-5'-[(n-dimethyl)amino]-8- methyl-adenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amd1, amd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (61 residues) CATH domain: 3.30.360.50
Bound ligands:   Het Group N8M is 58.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group PYR is 83.00% similar to enzyme cofactor pyruvate
3iwb
T. Maritima adometdc in processed form
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: speh, tm_0655. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A, D, C (59 residues)
3iwc
T. Maritima adometdc complex with s-adenosylmethionine methyl ester
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: speh, tm_0655. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A, D, C (61 residues)
Bound ligand:   Het Group SMM is 96.00% similar to enzyme reactant S-adenosyl-L-methionine
3iwd
T. Maritima adometdc complex with 5'-deoxy-5'-dimethyl thioadenosine
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: speh, tm_0655. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A, D, C (61 residues)
Bound ligand:   Het Group M2T is 77.00% similar to enzyme reactant S-adenosyl-L-methionine