_EC 4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). 38 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,237 PDB entries]
EC 4.1.1.- Carboxy-lyases. [740 PDB entries]
EC 4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). [38 PDB entries]    
1khb

Reaction: Gtp + oxaloacetate = gdp + phosphoenolpyruvate + CO(2).
 


GTP
+
oxaloacetate
=
GDP
+
phosphoenolpyruvate
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Pep carboxykinase. Pepck. Phosphoenolpyruvate carboxykinase. Phosphoenolpyruvate carboxylase. Phosphopyruvate carboxylase.
Comments: Itp can act as phosphate donor.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 38 PDB entries in enzyme class E.C.4.1.1.32

  PDB code Protein
1khb
Pepck complex with nonhydrolyzable gtp analog, native data
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (603 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GCP is 81.00% similar to enzyme product GDP
  Het Group ACT is 75.00% similar to enzyme product CO(2)
1khe
Pepck complex with nonhydrolyzable gtp analog, mad data
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (603 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group GCP is 81.00% similar to enzyme product GDP
1khf
Pepck complex with pep
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (603 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
  Het Group EDO is 40.00% similar to enzyme product CO(2)
1khg
Pepck
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (603 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group EDO is 44.00% similar to enzyme reactant oxaloacetate
1m51
Pepck complex with a gtp-competitive inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (603 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group ACT is 75.00% similar to enzyme product CO(2)
1nhx
Pepck complex with a gtp-competitive inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (605 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
  Het Group EDO is 40.00% similar to enzyme product CO(2)
2faf
The structure of chicken mitochondrial pepck.
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Other_details: liver mitochondrial ioszyme
Chains: A, B (596 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
2fag
The structure of chicken mitochondrial pepck.
Source: Gallus gallus. Chicken. Other_details: liver mitochondrial isozyme
Chains: A, B (596 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
2fah
The structure of mitochondrial pepck, complex with mn and gd
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Other_details: liver mitochondrial isozyme
Chains: A, B, C, D (608 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group MLA is 60.00% similar to enzyme reactant oxaloacetate
  Het Group GDP corresponds to enzyme product GDP
2gmv
Pepck complex with a gtp-competitive inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (602 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
2qew
Rat cytosolic pepck, in complex with manganese ion.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (613 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
2qey
Rat cytosolic pepck in complex with gtp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (610 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group EDO is 44.44% similar to enzyme reactant oxaloacetate
2qf1
Rat cytosolic pepck in complex with oxaloacetic acid.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (606 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group OAA corresponds to enzyme reactant oxaloacetate
2qf2
Rat cytosolic pepck in complex with oxaloacetic acid and gdp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (613 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group OAA corresponds to enzyme reactant oxaloacetate
  Het Group GDP corresponds to enzyme product GDP
  Het Group PYR is 50.00% similar to enzyme product CO(2)
2qzy
The structure of chicken mitochondrial pepck in complex with
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Other_details: mature mitochondrial protein
Chains: A, B (596 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
2rk7
The structure of rat cytosolic pepck in complex with oxalate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (610 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group OXL is 50.00% similar to enzyme reactant oxaloacetate
2rk8
The structure of rat cytosolic pepck in complex with phospho
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (622 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group PPF is 42.86% similar to enzyme product CO(2)
2rka
The structure of rat cytosolic pepck in complex with phospho
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (611 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligand:   Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
2rkd
The structure of rat cytosolic pepck in complex with 3- phosphonopropionate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (613 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
2rke
The structure of rat cytosolic pepck in complex with sulfoac
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (612 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
2zci
Structure of a gtp-dependent bacterial pep-carboxykinase from corynebacterium glutamicum
Source: Corynebacterium glutamicum. Organism_taxid: 1718. Other_details: gene pckg, pck
Chains: A, B, C, D (586 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
3dt2
The structure of rat cytosolic pepck in complex with oxalate
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (621 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group OXL is 50.00% similar to enzyme reactant oxaloacetate
3dt4
The structure of rat cytosolic pepck in complex with oxalate
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (619 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group OXL is 50.00% similar to enzyme reactant oxaloacetate
3dt7
The structure of rat cytosolic pepck in complex with beta- sulfopyruvate and gtp
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (624 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group SPV is 46.15% similar to enzyme reactant oxaloacetate
3dtb
The structure of rat cytosolic pepck in complex with phospho and gdp
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (620 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GDP corresponds to enzyme product GDP
  Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
  Het Group BCT is 75.00% similar to enzyme product CO(2)
3moe
The structure of rat cytosolic pepck mutant a467g in complex beta-sulfopyruvate and gtp
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (618 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group SPV is 46.15% similar to enzyme reactant oxaloacetate
  Het Group EDO is 40.00% similar to enzyme product CO(2)
3mof
The structure of rat cytosolic pepck mutant a467g in complex oxalate and gtp
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (624 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group OXL is 50.00% similar to enzyme reactant oxaloacetate
3moh
The structure of rat cytosolic pepck mutant a467g in complex phosphoglycolate and gdp
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (604 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group EDO is 44.44% similar to enzyme reactant oxaloacetate
  Het Group GDP corresponds to enzyme product GDP
  Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
4gmm
Structure of rat cytosolic pepck ld_1g in complex with beta- sulfopyruvate and gtp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (610 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group SPV is 46.15% similar to enzyme reactant oxaloacetate
4gmu
Structure of rat cytosolic pepck ld_1g in complex with oxala
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (610 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group OXL is 50.00% similar to enzyme reactant oxaloacetate
4gmw
Structure of rat cytosolic pepck ld_1g in complex with pep a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (611 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GDP corresponds to enzyme product GDP
  Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
4gmz
Structure of rat cytosolic pepck ld_2g in complex with beta- sulfopyruvate and gtp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (612 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group SPV is 46.15% similar to enzyme reactant oxaloacetate
4gnl
Structure of rat cytosolic pepck ld_2g in complex with pep a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (604 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GDP corresponds to enzyme product GDP
  Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
4gnm
Structure of rat cytosolic pepck ld_2g in complex with oxala
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (608 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group OXL is 50.00% similar to enzyme reactant oxaloacetate
4gno
Structure of rat cytosolic pepck ld_3g in complex with beta- sulfopyruvate and gtp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (613 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group SPV is 46.15% similar to enzyme reactant oxaloacetate
4gnp
Structure of rat cytosolic pepck ld_3g in complex with pep a
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (605 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GDP corresponds to enzyme product GDP
  Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
4gnq
Structure of rat cytosolic pepck ld_3g in complex with oxala
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (612 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group OXL is 50.00% similar to enzyme reactant oxaloacetate
4ox2
I45t cytosolic phosphoenolpyruvate carboxykinase in complex sulfopyruvate and gtp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: pck1,pck1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (608 residues) CATH domains: 3.40.449.10 2.170.8.10 3.90.228.20
Bound ligands:   Het Group GTP corresponds to enzyme reactant GTP
  Het Group SPV is 46.15% similar to enzyme reactant oxaloacetate