_EC 4.1.1.28 Aromatic-L-amino-acid decarboxylase. 6 PDB entries  
EC 4.-.-.- Lyases. [3,670 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,229 PDB entries]
EC 4.1.1.- Carboxy-lyases. [727 PDB entries]
EC 4.1.1.28 Aromatic-L-amino-acid decarboxylase. [6 PDB entries]    
1js3

Pathway: Dopa Biosynthesis
Reaction: (1) L-dopa = dopamine + CO(2). (2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).
 


L-dopa
=
dopamine
+
CO(2)

5-hydroxy-L-tryptophan
=
5-hydroxytryptamine
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 5-hydroxytryptophan decarboxylase. Aromatic amino acid decarboxylase. Dopa decarboxylase. Hydroxytryptophan decarboxylase. L-Dopa decarboxylase. Tryptophan decarboxylase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also acts on other aromatic L-amino acids, including L-tryptophan. Formerly Ec 4.1.1.26 and Ec 4.1.1.27.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.4.1.1.28

  PDB code Protein
1js3
Crystal structure of dopa decarboxylase in complex with the carbidopa
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: 1.20.1340.10 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group 142 is 87.50% similar to enzyme reactant 3,4-dihydroxy-L-phenylalanine
  Het Group 142 is 68.42% similar to enzyme reactant 5-hydroxy-L-tryptophan
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1js6
Crystal structure of dopa decarboxylase
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: kidney. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: 1.20.1340.10 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3k40
Crystal structure of drosophila 3,4-dihydroxyphenylalanine decarboxylase
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg10697, ddc. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: hypoderm isoform
Chains: A, B (448 residues) CATH domains: 1.20.1340.10 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group GOL is 41.00% similar to enzyme product 3,4-dihydroxyphenethylamine
3rbf
Crystal structure of human aromatic l-amino acid decarboxyla in the apo form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadc, ddc, hcg_1811384, tcag7.584. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (443 residues) CATH domains: 1.20.1340.10 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group PLP corresponds to enzyme cofactor pyridoxal
3rbl
Crystal structure of human aromatic l-amino acid decarboxyla in the apo form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (442 residues) CATH domains: 1.20.1340.10 3.40.640.10 3.90.1150.10
3rch
Crystal structure of human aromatic l-amino acid decarboxyla in the open conformation with llp and plp bound to chain-a b respectively
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (446 residues) CATH domains: 1.20.1340.10 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group PLP corresponds to enzyme cofactor pyridoxal