_EC 4.1.1.21 Phosphoribosylaminoimidazole carboxylase. 14 PDB entries  
EC 4.-.-.- Lyases. [3,638 PDB entries]
EC 4.1.-.- Carbon-carbon lyases. [1,237 PDB entries]
EC 4.1.1.- Carboxy-lyases. [740 PDB entries]
EC 4.1.1.21 Phosphoribosylaminoimidazole carboxylase. [14 PDB entries]    
2h31

Pathway: Purine Biosynthesis (late stages)
Reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1- (5-phospho-D-ribosyl)imidazole + CO(2).
 


5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
=
5-amino-1- (5-phospho-D-ribosyl)imidazole
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase. 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase. 5-amino-1-ribosylimidazole 5-phosphate carboxylase. 5-phosphoribosyl-5-aminoimidazole carboxylase. Air carboxylase.
Comments: While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely Ec 6.3.4.18 and Ec 5.4.99.18. 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.4.1.1.21

  PDB code Protein
2h31
Crystal structure of human paics, a bifunctional carboxylase synthetase in purine biosynthesis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: paics, ade2, airc, pais. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (386 residues) CATH domains: Unassigned 3.40.50.7700
Bound ligand:   Het Group CO2 corresponds to enzyme product CO(2)
3ax6
Crystal structure of n5-carboxyaminoimidazole ribonucleotide synthetase from thermotoga maritima
Source: Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Gene: tm_0447. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (360 residues) CATH domains: Unassigned Unassigned 3.30.470.20
3q2o
Crystal structure of purk: n5-carboxyaminoimidazole ribonucl synthetase
Source: Bacillus anthracis. Organism_taxid: 592021. Strain: a0248. Gene: baa_0344, purk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (377 residues) CATH domains: Unassigned Unassigned 3.30.470.20
3qff
Crystal structure of adp complex of purk: n5-carboxyaminoimi ribonucleotide synthetase
Source: Bacillus anthracis. Organism_taxid: 592021. Strain: a0248. Gene: baa_0344, purk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (377 residues) CATH domains: Unassigned Unassigned 3.30.470.20
Bound ligand:   Het Group ADP is 70.37% similar to enzyme product 5-amino-1-
3r5h
Crystal structure of adp-air complex of purk: n5-carboxyamin ribonucleotide synthetase
Source: Bacillus anthracis. Organism_taxid: 592021. Strain: a0248. Gene: baa_0344, purk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (383 residues) CATH domains: Unassigned Unassigned 3.30.470.20
Bound ligand:   Het Group ADP is 70.37% similar to enzyme product 5-amino-1-
3uvz
Crystal structure of phosphoribosylaminoimidazole carboxylas subunit from burkholderia ambifaria
Source: Burkholderia ambifaria. Organism_taxid: 398577. Strain: mc40-6. Gene: bammc406_2543. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (386 residues) CATH domains: Unassigned 3.30.1490.20 3.30.470.20
3v4s
Crystal structure of adp-atp complex of purk: n5-carboxyamin ribonucleotide synthetase
Source: Bacillus anthracis. Organism_taxid: 592021. Strain: a0248. Gene: baa_0344, purk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (380 residues) CATH domains: Unassigned Unassigned 3.30.470.20
Bound ligands:   Het Group ADP is 70.37% similar to enzyme product 5-amino-1-
  Het Group CO3 is 75.00% similar to enzyme product CO(2)
4dlk
Crystal structure of atp-ca++ complex of purk: n5- carboxyaminoimidazole ribonucleotide synthetase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 592021. Strain: a0248. Gene: bas0276, ba_0289, gbaa_0289, purk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (380 residues) CATH domains: Unassigned Unassigned 3.30.470.20
Bound ligand:   Het Group ATP is 61.29% similar to enzyme product 5-amino-1-
4e4t
Crystal structure of phosphoribosylaminoimidazole carboxylas subunit from burkholderia ambifaria
Source: Burkholderia ambifaria. Organism_taxid: 398577. Strain: mc40-6. Gene: bammc406_2543. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (391 residues) CATH domains: Unassigned 3.30.1490.20 3.30.470.20
4izo
Crystal structure of kinase phosphoribosylaminoimidazole car atpase subunit from burkholderia thailandensis
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264. Gene: bth_i0668, purk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (376 residues) CATH domains: Unassigned 3.30.1490.20 3.30.470.20
4m9u
The crystal structure of phosphoribosylaminoimidazole carbox atpase subunit of francisella tularensis subsp. Tularensis
Source: Francisella tularensis subsp. Tularens organism_taxid: 177416. Strain: schu s4. Gene: ftt_0897, purk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (365 residues) CATH domains: Unassigned 3.30.1490.20 3.30.470.20
Bound ligand:   Het Group ACT is 75.00% similar to enzyme product CO(2)
4ma0
The crystal structure of phosphoribosylaminoimidazole carbox atpase subunit of francisella tularensis subsp. Tularensis complex with partially hydrolysed atp
Source: Francisella tularensis subsp. Tularens organism_taxid: 177416. Strain: schu s4. Gene: ftt_0897, purk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (366 residues) CATH domains: Unassigned 3.30.1490.20 3.30.470.20
Bound ligand:   Het Group AMP is 82.61% similar to enzyme product 5-amino-1-
4ma5
The crystal structure of phosphoribosylaminoimidazole carbox atpase subunit of francisella tularensis subsp. Tularensis complex with an atp analog, amp-pnp.
Source: Francisella tularensis subsp. Tularens organism_taxid: 177416. Strain: schu s4. Gene: ftt_0897, purk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (363 residues) CATH domains: Unassigned 3.30.1490.20 3.30.470.20
Bound ligands:   Het Group ANP is 61.29% similar to enzyme product 5-amino-1-
  Het Group FMT corresponds to enzyme product CO(2)
4mam
The crystal structure of phosphoribosylaminoimidazole carbox atpase subunit of francisella tularensis subsp. Tularensis complex with an adp analog, amp-cp
Source: Francisella tularensis subsp. Tularens organism_taxid: 177416. Strain: schu s4. Gene: ftt_0897, purk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (373 residues) CATH domains: Unassigned 3.30.1490.20 3.30.470.20
Bound ligand:   Het Group A12 is 64.29% similar to enzyme product 5-amino-1-