_EC 3.6.3.9 Sodium/potassium-exchanging ATPase. 11 PDB entries  
EC 3.-.-.- Hydrolases. [19,780 PDB entries]
EC 3.6.-.- Acting on acid anhydrides. [2,042 PDB entries]
EC 3.6.3.- Acting on acid anhydrides; catalyzing transmembrane movement of s [308 PDB entries]
EC 3.6.3.9 Sodium/potassium-exchanging ATPase. [11 PDB entries]    
1mo7

Reaction: Atp + H(2)O + Na(+)(In) + K(+)(Out) = adp + phosphate + Na(+)(Out) + K(+)(In).
 


ATP
+ H(2)O
+ Na(+)(In)
+ K(+)(Out)
=
ADP
+
phosphate
+ Na(+)(Out)
+ K(+)(In)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Na(+)/K(+)-ATPase. Na(+)/K(+)-exchanging ATPase. Na,K-activated ATPase. Sodium pump. Sodium/potassium-transporting ATPase.
Cofactor(s): Magnesium.
Comments: P-type ATPase that undergoes covalent phosphorylation during the transport cycle. An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per Atp hydrolyzed. It is involved in generating the plasma membrane electrical potential. Formerly Ec 3.6.1.37.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.3.6.3.9

  PDB code Protein
1mo7
Atpase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (213 residues) CATH domain: 3.40.1110.10
1mo8
Atpase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (213 residues) CATH domain: 3.40.1110.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1q3i
Crystal structure of na,k-atpase n-domain
Source: Sus scrofa. Pig. Organism_taxid: 9823. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (192 residues) CATH domain: 3.40.1110.10
3b8e
Crystal structure of the sodium-potassium pump
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: kidney. Tissue: kidney
Chains: A, C (998 residues) CATH domains: 2.70.150.10 1.20.1110.10 3.40.50.1000 3.40.1110.10
Bound ligand:   Het Group PC1 is 41.00% similar to enzyme product ATP
3kdp
Crystal structure of the sodium-potassium pump
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: medula. Tissue: medula
Chains: A, C (998 residues) CATH domains: 2.70.150.10 1.20.1110.10 3.40.50.1000 3.40.1110.10
3n23
Crystal structure of the high affinity complex between ouaba e2p form of the sodium-potassium pump
Source: Sus scrofa. Pigs. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, C (992 residues)
3n2f
Crystal structure of the sodium-potassium pump
Source: Sus scrofa. Pigs. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, C (992 residues)
3wgu
Crystal structure of a na+-bound na+,k+-atpase preceding the without oligomycin
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, C (994 residues) CATH domains: 2.70.150.10 1.20.1110.10 3.40.50.1000 3.40.1110.10
Bound ligand:   Het Group ADP corresponds to enzyme product ATP
3wgv
Crystal structure of a na+-bound na+,k+-atpase preceding the with oligomycin
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, C (994 residues) CATH domains: 2.70.150.10 1.20.1110.10 3.40.50.1000 3.40.1110.10
Bound ligand:   Het Group ADP corresponds to enzyme product ATP
4hqj
Crystal structure of na+,k+-atpase in the na+-bound state
Source: Sus scrofa. Pigs. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, C (985 residues)
4hyt
Na,k-atpase in the e2p state with bound ouabain and mg2+ in cation-binding site
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, C (996 residues) CATH domains: 2.70.150.10 1.20.1110.10 3.40.50.1000 3.40.1110.10
Bound ligand:   Het Group NAG is 41.38% similar to enzyme product ATP