_EC 3.6.1.5 Apyrase. 3 PDB entries  
EC 3.-.-.- Hydrolases. [17,508 PDB entries]
EC 3.6.-.- Acting on acid anhydrides. [1,786 PDB entries]
EC 3.6.1.- In phosphorous-containing anhydrides. [814 PDB entries]
EC 3.6.1.5 Apyrase. [3 PDB entries]    
3zx0

Reaction: A nucleoside 5'-triphosphate + 2 H(2)O = a nucleoside 5'-phosphate + 2 phosphate.
 

nucleoside 5'-triphosphate
+ 2 × H(2)O
=
nucleoside 5'-phosphate
+
2 × phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Adenosine diphosphatase. ADPase. ATP-diphosphatase. ATP-diphosphohydrolase.
Cofactor(s): Ca(2+).
Comments: Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyze Atp, by hydrolyzing both Atp and adp. Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 3 PDB entries in enzyme class E.C.3.6.1.5

  PDB code Protein
3zx0
Ntpdase1 in complex with heptamolybdate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: escherichia coli.
Chains: A, B, C, D (385 residues) CATH domains: Unassigned Unassigned
3zx2
Ntpdase1 in complex with decavanadate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: escherichia coli.
Chains: A, B, C, D (396 residues) CATH domains: Unassigned Unassigned
3zx3
Crystal structure and domain rotation of ntpdase1 cd39
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (399 residues) CATH domains: Unassigned Unassigned