_EC 3.6.1.45 UDP-sugar diphosphatase. 9 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.6.-.- Acting on acid anhydrides. [2,179 PDB entries]
EC 3.6.1.- In phosphorous-containing anhydrides. [995 PDB entries]
EC 3.6.1.45 UDP-sugar diphosphatase. [9 PDB entries]    
1ho5

Reaction: UDP-sugar + H(2)O = Ump + alpha-D-aldose 1-phosphate.
 

UDP-sugar
+ H(2)O
=
UMP
+ alpha-D-aldose 1-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Nucleosidediphosphate-sugar diphosphatase. Nucleosidediphosphate-sugar pyrophosphatase. UDP-sugar hydrolase. UDP-sugar pyrophosphatase.
Cofactor(s): Divalent cation.
Comments: UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of Ec 3.6.1.21. Some but not all enzymes of this class also appear to have Ec 3.1.3.5 activity.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 9 PDB entries in enzyme class E.C.3.6.1.45

  PDB code Protein
1ho5
5'-nucleotidase (e. Coli) in complex with adenosine and phosphate
Source: Escherichia coli. Organism_taxid: 562. Gene: usha. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (525 residues) CATH domains: 3.60.21.10 3.90.780.10
Bound ligand:   Het Group ADN is 60.00% similar to enzyme product UMP
1hp1
5'-nucleotidase (open form) complex with atp
Source: Escherichia coli. Organism_taxid: 562. Gene: usha. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (516 residues) CATH domains: 3.60.21.10 3.90.780.10
Bound ligand:   Het Group ATP is 57.00% similar to enzyme product UMP
1hpu
5'-nucleotidase (closed form), complex with ampcp
Source: Escherichia coli. Organism_taxid: 562. Gene: usha. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (525 residues) CATH domains: 3.60.21.10 3.90.780.10
Bound ligand:   Het Group A12 is 60.00% similar to enzyme product UMP
1oi8
5'-nucleotidase (e. Coli) with an engineered disulfide bridge (p90c, l424c)
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: disulfide crosslink between n- and c-termina
Chains: A, B (526 residues) CATH domains: 3.60.21.10 3.90.780.10
1oid
5'-nucleotidase (e. Coli) with an engineered disulfide bridge (s228c, p513c)
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: disulfide crosslink between n- and c-termina
Chains: A, B (525 residues) CATH domains: 3.60.21.10 3.90.780.10
1oie
5'-nucleotidase (e. Coli) with an engineered disulfide bridge (s228c, p513c)
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: disulfide crosslink between n- and c-termina
Chain: A (520 residues) CATH domains: 3.60.21.10 3.90.780.10
1ush
5'-nucleotidase from e. Coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: usha. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (515 residues) CATH domains: 3.60.21.10 3.90.780.10
2ush
5'-nucleotidase from e. Coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: usha. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (506 residues) CATH domains: 3.60.21.10 3.90.780.10
3q91
Crystal structure of human uridine diphosphate glucose pyrop (nudt14)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nudt14, ugpp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (145 residues) CATH domain: 3.90.79.10