_EC 3.6.1.23 dUTP diphosphatase. 99 PDB entries  
EC 3.-.-.- Hydrolases. [21,295 PDB entries]
EC 3.6.-.- Acting on acid anhydrides. [2,201 PDB entries]
EC 3.6.1.- In phosphorous-containing anhydrides. [1,003 PDB entries]
EC 3.6.1.23 dUTP diphosphatase. [99 PDB entries]    
1b11

Reaction: dUTP + H(2)O = dUMP + diphosphate.
 


dUTP
+ H(2)O
=
dUMP
+
diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Deoxyuridine-triphosphatase. Desoxyuridine 5'-triphosphatase. Desoxyuridine 5'-triphosphate nucleotidohydrolase. dUTP pyrophosphatase. dUTPase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 99 PDB entries in enzyme class E.C.3.6.1.23

  PDB code Protein
1b11
Structure of feline immunodeficiency virus protease complexe 3-093
Source: Feline immunodeficiency virus. Organism_taxid: 11673
Chain: A (113 residues) CATH domain: 2.40.70.10
1dud
Deoxyuridine 5'-triphosphate nucleotide hydrolase (d-utpase) with the substrate analogue deoxyuridine 5'-diphosphate (d-
Source: Escherichia coli. Organism_taxid: 562
Chain: A (136 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUD is 85.71% similar to enzyme reactant dUTP
1dup
Deoxyuridine 5'-triphosphate nucleotido hydrolase (d-utpase)
Source: Escherichia coli. Organism_taxid: 562. Cell_line: s2
Chain: A (136 residues) CATH domain: 2.70.40.10
1dut
Fiv dutp pyrophosphatase
Source: Feline immunodeficiency virus. Organism_taxid: 11674. Strain: (isolate petaluma). Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tn5.
Chains: A, B (117 residues) CATH domain: 2.70.40.10
1eu5
Structure of e. Coli dutpase at 1.45 a
Source: Escherichia coli. Organism_taxid: 562
Chain: A (136 residues) CATH domain: 2.70.40.10
1euw
Atomic resolution structure of e. Coli dutpase
Source: Escherichia coli. Organism_taxid: 562
Chain: A (136 residues) CATH domain: 2.70.40.10
1f7d
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (118 residues) CATH domain: 2.70.40.10
1f7k
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (117 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
1f7n
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (117 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
1f7o
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B, C (116 residues) CATH domain: 2.70.40.10
1f7p
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B, C (116 residues) CATH domain: 2.70.40.10
1f7q
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B, C (116 residues) CATH domain: 2.70.40.10
1f7r
Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three cryst
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chain: A (133 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UDP is 85.71% similar to enzyme reactant dUTP
1fiv
Structure of an inhibitor complex of proteinase from feline immunodeficiency virus
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (113 residues) CATH domain: 2.40.70.10
1mq7
Crystal structure of dutpase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: rv2697c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (134 residues) CATH domain: 2.70.40.10
1q5h
Human dutp pyrophosphatase complex with dudp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (127 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUD is 85.71% similar to enzyme reactant dUTP
1q5u
Human dutp pyrophosphatase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hdut. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: X, Y, Z (131 residues) CATH domain: 2.70.40.10
1rn8
Crystal structure of dutpase complexed with substrate analogue imido-dutp
Source: Escherichia coli. Organism_taxid: 562. Gene: dut, dnas, sof, b3640. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (140 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.00% similar to enzyme product dUMP
1rnj
Crystal structure of inactive mutant dutpase complexed with analogue imido-dutp
Source: Escherichia coli. Organism_taxid: 562. Gene: dut, dnas, sof, b3640. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (140 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
1seh
Crystal structure of e. Coli dutpase complexed with the prod
Source: Escherichia coli. Organism_taxid: 562. Gene: dut. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (140 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
1six
Mycobacterium tuberculosis dutpase complexed with magnesium beta-imido-dutp
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c, mb2716c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (153 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
1sjn
Mycobacterium tuberculosis dutpase complexed with magnesium beta-imido-dutp
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c, mb2716c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (131 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
1slh
Mycobacterium tuberculosis dutpase complexed with magnesium and dudp
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c, mb2716c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (135 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUD is 85.00% similar to enzyme reactant dUTP
1sm8
M. Tuberculosis dutpase complexed with chromium and dutp
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c, mb2716c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (131 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUT corresponds to enzyme reactant dUTP
1smc
Mycobacterium tuberculosis dutpase complexed with dutp in th of metal ion.
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c, mb2716c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (131 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUT corresponds to enzyme reactant dUTP
1snf
Mycobacterium tuberculosis dutpase complexed with magnesium deoxyuridine 5'-monophosphate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c, mb2716c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (131 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
1syl
Crystal structure of inactive mutant dutpase complexed with dutp
Source: Escherichia coli. Organism_taxid: 562. Gene: dut. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (137 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUT corresponds to enzyme reactant dUTP
1w2y
The crystal structure of a complex of campylobacter jejuni dutpase with substrate analogue dupnhp
Source: Campylobacter jejuni. Organism_taxid: 197. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (226 residues) CATH domain: 1.10.4010.10
Bound ligand:   Het Group DUN is 76.00% similar to enzyme product dUMP
2baz
Structure of yoss, a putative dutpase from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (128 residues) CATH domain: 2.70.40.10
2bsy
Epstein barr virus dutpase
Source: Human herpesvirus 4. Epstein-barr virus. Organism_taxid: 10376. Strain: b95-8. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (249 residues) CATH domains: Unassigned 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
2bt1
Epstein barr virus dutpase in complex with a,b-imino dutp
Source: Human herpesvirus 4. Epstein-barr virus. Organism_taxid: 10376. Strain: b95-8. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (254 residues) CATH domains: Unassigned 2.70.40.10
Bound ligand:   Het Group DUP is 65.00% similar to enzyme product dUMP
2cic
The crystal structure of a complex of campylobacter jejuni dutpase with substrate analogue dupnhpp
Source: Campylobacter jejuni. Organism_taxid: 197. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (223 residues) CATH domain: 1.10.4010.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
2cje
The crystal structure of a complex of leishmania major dutpase with substrate analogue dupnhp
Source: Leishmania major. Organism_taxid: 5664. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (258 residues) CATH domains: 1.20.1680.10 1.20.1670.10
Bound ligand:   Het Group DUN is 76.00% similar to enzyme product dUMP
2fiv
Crystal structure of feline immunodeficiency virus protease with a substrate
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (113 residues) CATH domain: 2.40.70.10
2hah
The structure of fiv 12s protease in complex with tl-3
Source: Feline immunodeficiency virus (isolate petaluma). Organism_taxid: 11674. Strain: isolate petaluma. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (112 residues) CATH domain: 2.40.70.10
2hqu
Human dutpase in complex with alpha,beta-iminodutp and magne
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dutn. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (138 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
2hr6
Crystal structure of dutpase in complex with substrate analo and manganese
Source: Escherichia coli. Organism_taxid: 562. Gene: dut. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (137 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUD is 85.71% similar to enzyme reactant dUTP
2hrm
Crystal structure of dutpase complexed with substrate analog methylene-dutp
Source: Escherichia coli. Organism_taxid: 562. Gene: dut. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (137 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UC5 is 76.00% similar to enzyme product dUMP
2okb
High resolution crystal structures of vaccinia virus dutpase
Source: Vaccinia virus. Organism_taxid: 10245. Gene: dut. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (113 residues) CATH domain: 2.70.40.10
2okd
High resolution crystal structures of vaccinia virus dutpase
Source: Vaccinia virus. Organism_taxid: 10245. Gene: dut. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (124 residues) CATH domain: 2.70.40.10
2oke
High resolution crystal structures of vaccinia virus dutpase
Source: Vaccinia virus. Organism_taxid: 10245. Gene: dut. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (123 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.00% similar to enzyme product dUMP
2ol0
High resolution crystal structures of vaccinia virus dutpase
Source: Vaccinia virus. Organism_taxid: 10245. Gene: dut. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (124 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUD is 85.71% similar to enzyme reactant dUTP
2ol1
High resolution crystal structures of vaccinia virus dutpase
Source: Vaccinia virus. Organism_taxid: 10245. Gene: dut. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (124 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
2p9o
Structure of dutpase from arabidopsis thaliana
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: t6h20.30. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (128 residues) CATH domain: 2.70.40.10
2pc5
Native crystal structure analysis on arabidopsis dutpase
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: t6h20.30. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (127 residues) CATH domain: 2.70.40.10
2py4
Full length structure of the mycobacterium tuberculosis dutp complexed with magnesium and alpha,beta-imido-dutp.
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (153 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
2we0
Ebv dutpase mutant cys4ser
Source: Human herpesvirus 4. Epstein-barr virus. Organism_taxid: 10377. Strain: b95-8. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (247 residues) CATH domains: Unassigned 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
2we1
Ebv dutpase mutant asp131asn with bound dump
Source: Human herpesvirus 4. Epstein-barr virus. Organism_taxid: 10377. Strain: b95-8. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (245 residues) CATH domains: Unassigned 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
2we2
Ebv dutpase double mutant gly78asp-asp131ser with dump
Source: Human herpesvirus 4. Epstein-barr virus. Organism_taxid: 10377. Strain: b95-8. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (248 residues) CATH domains: Unassigned 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
2we3
Ebv dutpase inactive mutant deleted of motif v
Source: Human herpesvirus 4. Epstein-barr virus. Organism_taxid: 10377. Strain: b95-8. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (240 residues) CATH domains: Unassigned 2.70.40.10
Bound ligand:   Het Group DUT corresponds to enzyme reactant dUTP
2xcd
Structure of yncf,the genomic dutpase from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (129 residues) CATH domain: 2.70.40.10
2xce
Structure of yncf in complex with dupnhpp
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (129 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
2xx6
Structure of the bacillus subtilis prophage dutpase, yoss
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (128 residues) CATH domain: 2.70.40.10
2xy3
Structure of the bacillus subtilis prophage dutpase with dup
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: b834
Chains: A, B, C, D, E, F (128 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
2y1t
Bacillus subtilis prophage dutpase in complex with dudp
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (128 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUD is 85.71% similar to enzyme reactant dUTP
2yay
The crystal structure of leishmania major dutpase in complex with substrate analogue dupnpp
Source: Leishmania major. Organism_taxid: 5664. Strain: 252. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (257 residues) CATH domains: 1.20.1680.10 1.20.1670.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
2yaz
The crystal structure of leishmania major dutpase in complex dump
Source: Leishmania major. Organism_taxid: 5664. Strain: 252. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (257 residues) CATH domains: 1.20.1680.10 1.20.1670.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
2yb0
The crystal structure of leishmania major dutpase in complex deoxyuridine
Source: Leishmania major. Organism_taxid: 5664. Strain: 252. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (258 residues) CATH domains: 1.20.1680.10 1.20.1670.10
Bound ligand:   Het Group DUR is 80.00% similar to enzyme product dUMP
2yzj
Crystal structure of dctp deaminase from sulfolobus tokodaii
Source: Sulfolobus tokodaii. Organism_taxid: 111955. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (158 residues) CATH domain: 2.70.40.10
2zdc
Crystal structure of dutpase from sulfolobus tokodaii
Source: Sulfolobus tokodaii. Expressed in: escherichia coli.
Chains: A, B, C (143 residues) CATH domain: 2.70.40.10
3ara
Discovery of novel uracil derivatives as potent human dutpas inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (125 residues) CATH domain: 2.70.40.10
3arn
Human dutpase in complex with novel uracil derivative
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (125 residues) CATH domain: 2.70.40.10
3ehw
Human dutpase in complex with alpha,beta-imido-dutp and mg2+ visualization of the full-length c-termini in all monomers suggestion for an additional metal ion binding site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dut. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, X, Y, Z (141 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
3f4f
Crystal structure of dut1p, a dutpase from saccharomyces cer
Source: Saccharomyces cerevisiae. Organism_taxid: 4932. Gene: dut1, ybr252w, ybr1705. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (138 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
3fiv
Crystal structure of feline immunodeficiency virus protease with a substrate
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Cell_line: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (111 residues) CATH domain: 2.40.70.10
3h6d
Structure of the mycobacterium tuberculosis dutpase d28n mut
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, mt2771, mtcy05a6.18c, rv2697c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (145 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
3hhq
Crystal structure of apo dut1p from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Gene: dut1, dut1p, ybr1705, ybr252w. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (126 residues) CATH domain: 2.70.40.10
3hpg
Visna virus integrase (residues 1-219) in complex with ledgf ibd: examples of open integrase dimer-dimer interfaces
Source: Maedi visna virus. Mvv. Organism_taxid: 36374. Strain: kv1772. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
Chains: A, B, C, D, E, F (194 residues) CATH domains: 1.10.10.200 3.30.420.10
3hph
Closed tetramer of visna virus integrase (residues 1-219) in with ledgf ibd
Source: Maedi visna virus. Mvv. Organism_taxid: 36374. Strain: kv1772. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
Chains: A, B, C, D (194 residues) CATH domains: 1.10.10.200 3.30.420.10
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
3hza
Crystal structure of dutpase h145w mutant
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
3i93
Crystal structure of mycobacterium tuberculosis dutpase stop mutant
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, mt2771, mtcy05a6.18c, rv2697c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (140 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
3loj
Structure of mycobacterium tuberculosis dutpase h145a mutant
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, mt2771, mtcy05a6.18c, rv2697c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (160 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
3mbq
Crystal structure of deoxyuridine 5-triphosphate nucleotidoh from brucella melitensis, orthorhombic crystal form
Source: Brucella melitensis. Organism_taxid: 359391. Strain: 2308. Gene: dut, bab1_1687. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (135 residues) CATH domain: 2.70.40.10
3mdx
Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from brucella melitensis, rhombohedral crystal form
Source: Brucella melitensis. Organism_taxid: 359391. Strain: 2308. Gene: dut, bab1_1687. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (139 residues) CATH domain: 2.70.40.10
3ogp
Crystal structure of 6s-98s fiv protease with darunavir boun
Source: Feline immunodeficiency virus. Fiv. Organism_taxid: 11673. Gene: pol, pr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (112 residues) CATH domain: 2.40.70.10
3ogq
Crystal structure of 6s-98s fiv protease with lopinavir boun
Source: Feline immunodeficiency virus. Fiv. Organism_taxid: 11673. Gene: pol, pr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (112 residues) CATH domain: 2.40.70.10
3p48
Structure of the yeast dutpase dut1 in complex with dumpnpp
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: dut1, ybr252w, ybr1705. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (127 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
3tqz
Structure of a deoxyuridine 5'-triphosphate nucleotidohydrol from coxiella burnetii
Source: Coxiella burnetii. Organism_taxid: 777. Strain: rsa493. Gene: cbu_0293, dut. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (138 residues) CATH domain: 2.70.40.10
4ao5
B. Subtilis prophage dutpase yoss in complex with dump
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (128 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
4aoo
B. Subtilis dutpase yncf in complex with du ppi and mg in h3
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (143 residues) CATH domain: 2.70.40.10
Bound ligands:   Het Group DUR is 80.00% similar to enzyme product dUMP
  Het Group POP corresponds to enzyme product diphosphate
4aoz
B. Subtilis dutpase yncf in complex with du, ppi and mg (p21
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (130 residues) CATH domain: 2.70.40.10
Bound ligands:   Het Group DUR is 80.00% similar to enzyme product dUMP
  Het Group POP corresponds to enzyme product diphosphate
4apz
Structure of b. Subtilis genomic dutpase yncf in complex with du, ppi and mg in p1
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m (142 residues) CATH domain: 2.70.40.10
Bound ligands:   Het Group DUR is 80.00% similar to enzyme product dUMP
  Het Group POP corresponds to enzyme product diphosphate
4b0h
B. Subtilis dutpase yncf in complex with du, ppi and mg b (p
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (130 residues) CATH domain: 2.70.40.10
Bound ligands:   Het Group DUR is 80.00% similar to enzyme product dUMP
  Het Group POP corresponds to enzyme product diphosphate
4dk2
Crystal structure of open trypanosoma brucei dutpase
Source: Trypanosoma brucei. Organism_taxid: 5691. Strain: 427. Gene: tb927.7.5160. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (260 residues) CATH domains: 1.20.1680.10 1.20.1670.10
4dk4
Crystal structure of trypanosoma brucei dutpase with dupnp, na+
Source: Trypanosoma brucei. Organism_taxid: 5691. Strain: 427. Gene: tb927.7.5160. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (218 residues) CATH domain: 1.10.4010.10
Bound ligand:   Het Group DUN is 76.00% similar to enzyme product dUMP
4dkb
Crystal structure of trypanosoma brucei dutpase with dupnp a
Source: Trypanosoma brucei. Organism_taxid: 5691. Strain: 427. Gene: tb927.7.5160. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (223 residues) CATH domain: 1.10.4010.10
Bound ligand:   Het Group DUN is 76.00% similar to enzyme product dUMP
4dl8
Crystal structure of trypanosoma brucei dutpase with dump, p [alf3-opo3] transition state analogue, mg2+, and na+
Source: Trypanosoma brucei. Organism_taxid: 5691. Strain: 427. Gene: tb927.7.5160. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (224 residues) CATH domain: 1.10.4010.10
Bound ligands:   Het Group UMP corresponds to enzyme product dUMP
  Het Group PO4 is 55.56% similar to enzyme product diphosphate
4dlc
Crystal structure of trypanosoma brucei dutpase with dump, m transition state analogue, and mg2+
Source: Trypanosoma brucei. Organism_taxid: 5691. Strain: 427. Gene: tb927.7.5160. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (222 residues) CATH domain: 1.10.4010.10
Bound ligand:   Het Group UMP corresponds to enzyme product dUMP
4fdr
Structure of importin-alpha: dutpase nls complex
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: kpna2, rch1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human.
Chain: C (12 residues)
Bound ligand:   Het Group ARG is 40.91% similar to enzyme product dUMP
4fds
Structure of importin-alpha: dutpase s11e nls mutant complex
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: kpna2, rch1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human.
Chain: C (11 residues)
Bound ligand:   Het Group ARG is 40.91% similar to enzyme product dUMP
4fiv
Fiv protease complexed with an inhibitor lp-130
Source: Feline immunodeficiency virus. Organism_taxid: 11673. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (113 residues) CATH domain: 2.40.70.10
4gcy
Structure of mycobacterium tuberculosis dutpase h21w mutant
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dut, rv2697c, mt2771, mtcy05a6.18c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (163 residues) CATH domain: 2.70.40.10
Bound ligand:   Het Group DUP is 65.52% similar to enzyme product dUMP
4gk6
X-ray crystal structure of a hypothetical deoxyuridine 5-tri nucleotidohydrolase from mycobacterium abscessus
Source: Mycobacterium abscessus. Organism_taxid: 561007. Strain: atcc 19977 / dsm 44196. Gene: dut, mab_3003c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (136 residues) CATH domain: 2.70.40.10
4lhr
Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from burkholderia thailandensis
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264. Gene: bth_i0767, dut. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (134 residues) CATH domain: 2.70.40.10
4mq3
The 1.1 angstrom structure of catalytic core domain of fiv i
Source: Feline immunodeficiency virus. Fiv. Organism_taxid: 11674. Strain: isolate petaluma. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (129 residues)
4mz5
Structure of importin-alpha: dutpase nls complex
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Mus musculus. Mouse. Organism_taxid: 10090. Gene: kpna2, rch1. Expressed in: escherichia coli.
Chain: C (12 residues)
Bound ligand:   Het Group ARG is 40.91% similar to enzyme product dUMP
4pa1
Crystal structure of catalytic core domain of fiv integrase
Source: Feline immunodeficiency virus. Fiv. Organism_taxid: 11674. Strain: isolate petaluma. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (151 residues)
5fiv
Structural studies of HIV and fiv proteases complexed with a efficient inhibitor of fiv pr
Source: Feline immunodeficiency virus. Organism_taxid: 11674. Strain: (isolate petaluma). Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (112 residues) CATH domain: 2.40.70.10
6fiv
Structural studies of HIV and fiv proteases complexed with a efficient inhibitor of fiv pr
Source: Feline immunodeficiency virus. Organism_taxid: 11674. Strain: (isolate petaluma). Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (112 residues) CATH domain: 2.40.70.10