_EC 3.5.3.22 Proclavaminate amidinohydrolase. 2 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.5.-.- Acting on carbon-nitrogen bonds, other than peptide bonds. [1,666 PDB entries]
EC 3.5.3.- In linear amidines. [165 PDB entries]
EC 3.5.3.22 Proclavaminate amidinohydrolase. [2 PDB entries]    
1gq6

Pathway: Clavulanate Biosynthesis
Reaction: Amidinoproclavaminate + H(2)O = proclavaminate + urea.
 


Amidinoproclavaminate
+ H(2)O
=
proclavaminate
+
urea
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Pah. Proclavaminate amidino hydrolase. Proclavaminic acid amidino hydrolase.
Cofactor(s): Mn(2+).
Comments: Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It carries out an intermediary reaction between the first reaction of Ec 1.14.11.21, and the second and third reactions of that enzyme.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.3.5.3.22

  PDB code Protein
1gq6
Proclavaminate amidino hydrolase from streptomyces clavuligerus
Source: Streptomyces clavuligerus. Organism_taxid: 1901. Atcc: 27064. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (295 residues) CATH domain: 3.40.800.10
1gq7
Proclavaminate amidino hydrolase from streptomyces clavuligerus
Source: Streptomyces clavuligerus. Organism_taxid: 1901. Atcc: 27064. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3).
Chains: A, B, C, D, E, F (301 residues) CATH domain: 3.40.800.10