_EC 3.5.3.18 Dimethylargininase. 16 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.5.-.- Acting on carbon-nitrogen bonds, other than peptide bonds. [1,670 PDB entries]
EC 3.5.3.- In linear amidines. [165 PDB entries]
EC 3.5.3.18 Dimethylargininase. [16 PDB entries]    
1h70

Reaction: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
 

N(omega),N(omega)-dimethyl-L-arginine
+ H(2)O
=
dimethylamine
+
L-citrulline
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Dimethylarginine dimethylaminohydrolase. N(G),N(G)-dimethylarginine dimethylaminohydrolase.
Comments: Also acts on N(omega)-methyl-L-arginine.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 16 PDB entries in enzyme class E.C.3.5.3.18

  PDB code Protein
1h70
Ddah from pseudomonas aeruginosa. C249s mutant complexed with citrulline
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (255 residues) CATH domain: 3.75.10.10
2c6z
Crystal structure of dimethylarginine dimethylaminohydrolase i in complex with citrulline
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: brain
Chain: A (273 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group CIR corresponds to enzyme product citrulline
2ci1
Crystal structure of dimethylarginine dimethylaminohydrolase i in complex with s-nitroso- lhomocysteine
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: brain
Chain: A (276 residues) CATH domain: 3.75.10.10
2ci3
Crystal structure of dimethylarginine dimethylaminohydrolase crystal form i
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: brain
Chain: A (274 residues) CATH domain: 3.75.10.10
2ci4
Crystal structure of dimethylarginine dimethylaminohydrolase i crystal form ii
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: brain
Chain: A (273 residues) CATH domain: 3.75.10.10
2ci5
Crystal structure of dimethylarginine dimethylaminohydrolase i in complex with l-homocysteine
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: brain
Chains: A, B (272 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group HCS is 53.00% similar to enzyme product citrulline
2ci6
Crystal structure of dimethylarginine dimethylaminohydrolase i bound with zinc low ph
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: brain
Chain: A (274 residues) CATH domain: 3.75.10.10
2ci7
Crystal structure of dimethylarginine dimethylaminohydrolase i in complex with zinc, high ph
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: brain
Chain: A (273 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group GLY is 41.00% similar to enzyme product citrulline
2jai
Ddah1 complexed with citrulline
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: b834(de3).
Chains: A, B (271 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group CIR corresponds to enzyme product citrulline
2jaj
Ddah1 complexed with l-257
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (272 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group D20 is 64.71% similar to enzyme product L-citrulline
3bpb
Crystal structure of the dimethylarginine dimethylaminohydrolase h162g adduct with s-methyl-l- thiocitrulline
Source: Pseudomonas aeruginosa. Gene: pa1195. Expressed in: escherichia coli.
Chains: A, B (254 residues) CATH domain: 3.75.10.10
3i2e
Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (ddah-1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddah, ddah1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (275 residues) CATH domain: 3.75.10.10
3i4a
Crystal structure of dimethylarginine dimethylaminohydrolase 1) in complex with n5-(1-iminopropyl)-l-ornithine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddah, ddah1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (275 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group LN5 is 78.57% similar to enzyme product L-citrulline
3p8e
Crystal structure of human dimethylarginine dimethylaminohyd (ddah-1) covalently bound with n5-(1-iminopentyl)-l-ornithi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddah, ddah1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (272 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group LN7 is 68.00% similar to enzyme product citrulline
3p8p
Crystal structure of human dimethylarginine dimethylaminohyd (ddah-1) variant c274s bound with n5-(1-iminopentyl)-l-orni
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddah, ddah1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (275 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group LN6 is 68.00% similar to enzyme product citrulline
3rhy
Crystal structure of the dimethylarginine dimethylaminohydro adduct with 4-chloro-2-hydroxymethylpyridine
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: pa1195. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (248 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group HM3 is 53.85% similar to enzyme product citrulline