_EC 3.5.3.15 Protein-arginine deiminase. 12 PDB entries  
EC 3.-.-.- Hydrolases. [21,317 PDB entries]
EC 3.5.-.- Acting on carbon-nitrogen bonds, other than peptide bonds. [1,690 PDB entries]
EC 3.5.3.- In linear amidines. [166 PDB entries]
EC 3.5.3.15 Protein-arginine deiminase. [12 PDB entries]    
1wd8

Reaction: Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
 


Protein L-arginine
+ H(2)O
=
protein L-citrulline
+ NH(3)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.3.5.3.15

  PDB code Protein
1wd8
Calcium free form of human peptidylarginine deiminase type4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (559 residues) CATH domains: Unassigned 2.60.40.1700
1wd9
Calcium bound form of human peptidylarginine deiminase type4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (603 residues) CATH domains: Unassigned 2.60.40.1700
1wda
Crystal structure of human peptidylarginine deiminase type4 complex with benzoyl-l-arginine amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (628 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group BAG is 63.64% similar to enzyme reactant protein-L-arginine
2dew
Crystal structure of human peptidylarginine deiminase 4 in c with histone h3 n-terminal tail including arg8
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: X (629 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group ARG is 68.75% similar to enzyme reactant protein-L-arginine
2dex
Crystal structure of human peptidylarginine deiminase 4 in c with histone h3 n-terminal peptide including arg17
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: X (627 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group ARG is 68.75% similar to enzyme reactant protein-L-arginine
2dey
Crystal structure of human peptidylarginine deiminase 4 in c with histone h4 n-terminal tail including arg3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: X (628 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group ARG is 68.75% similar to enzyme reactant protein-L-arginine
2dw5
Crystal structure of human peptidylarginine deiminase 4 in c with n-alpha-benzoyl-n5-(2-fluoro-1-iminoethyl)-l-ornithine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (626 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group BFB is 56.52% similar to enzyme reactant protein-L-arginine
3apm
Crystal structure of the human snp pad4 protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (559 residues) CATH domains: Unassigned 2.60.40.1700
3apn
Crystal structure of the human wild-type pad4 protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (563 residues) CATH domains: Unassigned 2.60.40.1700
3b1t
Crystal structure of human peptidylarginine deiminase 4 in c with o-cl-amidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (624 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group YCL is 50.00% similar to enzyme reactant protein-L-arginine
3b1u
Crystal structure of human peptidylarginine deiminase 4 in c with o-f-amidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (628 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group YFF is 50.00% similar to enzyme reactant protein-L-arginine
4dkt
Crystal structure of human peptidylarginine deiminase 4 in c with n-acetyl-l-threonyl-l-alpha-aspartyl-n5-[(1e)-2- fluoroethanimidoyl]-l-ornithinamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: padi4, padi5, pdi5. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (636 residues) CATH domains: Unassigned 2.60.40.1700
Bound ligand:   Het Group FIO is 58.82% similar to enzyme reactant protein-L-arginine