_EC 3.5.1.24 Choloylglycine hydrolase. 7 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.5.-.- Acting on carbon-nitrogen bonds, other than peptide bonds. [1,670 PDB entries]
EC 3.5.1.- In linear amides. [598 PDB entries]
EC 3.5.1.24 Choloylglycine hydrolase. [7 PDB entries]    
2bjf

Reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H(2)O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine.
 


3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine
+ H(2)O
=
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate
+
glycine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Bile salt hydrolase. Glycocholase.
Comments: Also acts on the 3-alpha,12-alpha-dihydroxy-derivative, and on choloyl-taurine.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.3.5.1.24

  PDB code Protein
2bjf
Crystal structure of conjugated bile acid hydrolase from clostridium perfringens in complex with reaction products taurine and deoxycholate
Source: Clostridium perfringens. Organism_taxid: 1502. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domain: 3.60.60.10
Bound ligand:   Het Group DXC is 96.00% similar to enzyme product 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate
2bjg
Crystal structure of conjugated bile acid hydrolase from clostridium perfringens in complex with reaction products taurine and deoxycholate
Source: Clostridium perfringens. Organism_taxid: 1502. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (328 residues) CATH domain: 3.60.60.10
Bound ligand:   Het Group EDO is 50.00% similar to enzyme product Glycine
2hez
Bifidobacterium longum bile salt hydrolase
Source: Bifidobacterium longum. Organism_taxid: 216816. Gene: bsh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (316 residues) CATH domain: 3.60.60.10
2hf0
Bifidobacterium longum bile salt hydrolase
Source: Bifidobacterium longum. Organism_taxid: 216816. Gene: bsh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (316 residues) CATH domain: 3.60.60.10
2rf8
Crystal structure of the mutant c2a conjugated bile acid hyd from clostridium perfringens
Source: Clostridium perfringens. Gene: cbh. Expressed in: escherichia coli.
Chains: A, B (328 residues) CATH domain: 3.60.60.10
2rg2
Crystal structure of variant r18l of conjugated bile acid hy from clostridium perfringens
Source: Clostridium perfringens. Organism_taxid: 1502. Gene: cbh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (328 residues) CATH domain: 3.60.60.10
Bound ligand:   Het Group EDO is 50.00% similar to enzyme product Glycine
2rlc
Crystal structure of the conjugated bile acid hydrolase from clostridium perfringens in complex with reaction products glycine and cholate
Source: Clostridium perfringens. Organism_taxid: 1502. Gene: cbh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (328 residues) CATH domain: 3.60.60.10
Bound ligands:   Het Group CHD corresponds to enzyme product 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate
  Het Group GLY corresponds to enzyme product Glycine