_EC ADAM10 endopeptidase. 1 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.24.- Metalloendopeptidases. [610 PDB entries]
EC ADAM10 endopeptidase. [1 PDB entries]    

Reaction: Endopeptidase of broad specificity.
Other name(s): Kuzbanian protein. Myelin-associated disintegrin metalloproteinase.
Cofactor(s): Zn(2+).
Comments: Partially responsible for the 'alpha-secretase' activity in brain that degrades the potentially harmful beta-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signaling. Belongs to peptidase family M12.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1 PDB entries in enzyme class E.C.

  PDB code Protein
Adam10 disintegrin and cysteine- rich domain
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: adam10, madm. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293
Chain: A (146 residues)